Epistatic interaction between common AGT G(− 6)A (rs5051) and AGTR1 A1166C (rs5186) variants contributes to variation in kidney size at birth

Kaczmarczyk, Mariusz; Kuprjanowicz, Anna; Łoniewska, Beata; Gorący, Iwona; Taryma-Leśniak, Olga; Skonieczna-Żydecka, Karolina; Ciechanowicz, Andrzej

doi:10.1016/j.gene.2015.06.071

Cited by 3 publications

(1 citation statement)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7,8 Such findings suggest a potential risk to T2DM in subjects carrying the I allele of the ACE gene, which is consistent with our findings. Due to the inconsistency in findings and complexity of the RAAS it is possible that gene-gene interactions play a major role within this system, 34 and therefore it would be useful to investigate the interactions of other genetic markers in the RAAS in patients with T2DM.…”

Section: Discussionmentioning

confidence: 99%

Association of the insertion allele of the common ACE gene polymorphism with type 2 diabetes mellitus among Kuwaiti cardiovascular disease patients

Al-Serri

Ismael

Al-Bustan

et al. 2015

J Renin Angiotensin Aldosterone Syst

View full text Add to dashboard Cite

Background and objectives:The D allele of the common angiotensin-converting enzyme (ACE) I/D gene polymorphism (rs4646994) predisposes to type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). However, results on which allele predisposes to disease susceptibility remain controversial in Asian populations. This study was performed to evaluate the association of the common ACE I/D gene polymorphism with both T2DM and CVD susceptibility in an Arab population. Methods: We genotyped the ACE I/D polymorphisms by direct allele-specific PCR in 183 healthy controls and 400 CVD patients with diabetes (n=204) and without (n=196). Statistical analysis comparing between the different groups were conducted using R statistic package "SNPassoc". Results: Two genetic models were used: the additive and co-dominant models. The I allele was found to be associated with T2DM (OR=1.84, p=0.00009) after adjusting for age, sex and body mass index. However, there was no association with CVD susceptibility (p>0.05). Conclusion:The ACE I allele is found to be associated with T2DM; however, no association was observed with CVD. The inconsistency between studies is suggested to be attributed to genetic diversity due to the existence of subpopulations found in Asian populations.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of the insertion allele of the common ACE gene polymorphism with type 2 diabetes mellitus among Kuwaiti cardiovascular disease patients

Al-Serri

Ismael

Al-Bustan

et al. 2015

J Renin Angiotensin Aldosterone Syst

View full text Add to dashboard Cite

show abstract

Unravelling the Lesser Known Facets of Angiotensin II Type 1 Receptor

Chaudhary

2017

Curr Hypertens Rep

View full text Add to dashboard Cite

Various single gene and genome wide association studies have generated huge but non-reproducible data that highlights the role of some additional but as yet unidentified factor(s) in disease outcome. Dietary pattern and epigenetic mechanism (mainly DNA methylation) have shown a profound effect on blood pressure regulation. Angiotensin II and its receptors are known to play an important role in maintaining blood pressure; hence, a larger section of antihypertensive drugs targets the renin-angiotensin system (RAS). Angiotensin II type 1 receptor (AT1R), besides maintaining blood pressure, also has a role in cancer progression. Besides other pathways, RAS still remains the main player in blood pressure regulation. Additionally, AT1R has recently emerged as a molecule with diverse roles ranging from physiologic to cancer progression.

show abstract

Development of the Kidneys and Urinary Tract in Relation to Renal Anomalies

Winyard¹

2020

Fetal Medicine

View full text Add to dashboard Cite

Epistatic interaction between common AGT G(− 6)A (rs5051) and AGTR1 A1166C (rs5186) variants contributes to variation in kidney size at birth

Cited by 3 publications

References 53 publications

Association of the insertion allele of the common ACE gene polymorphism with type 2 diabetes mellitus among Kuwaiti cardiovascular disease patients

Association of the insertion allele of the common ACE gene polymorphism with type 2 diabetes mellitus among Kuwaiti cardiovascular disease patients

Unravelling the Lesser Known Facets of Angiotensin II Type 1 Receptor

Development of the Kidneys and Urinary Tract in Relation to Renal Anomalies

Contact Info

Product

Resources

About