Interactions of inflammatory pain and morphine in infant rats: long-term behavioral effects

Bhutta, Adnan T.; Rovnaghi, Cynthia R.; Simpson, Pippa; Gossett, Jeffrey M.; Scalzo, Frank M.; Anand, K.J.S.

doi:10.1016/s0031-9384(01)00432-2

Cited by 143 publications

(120 citation statements)

References 48 publications

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“…Thermal pain latencies were significantly reduced in the C and K groups compared with F and KF groups, confirming long-term effects of neonatal inflammatory pain (20). Ketamine appeared to ameliorate these long-term effects in adult females, but not in males (Fig.…”

Section: Repetitive Inflammatory Painsupporting

confidence: 53%

“…Hot plate (HP) testing for thermal pain thresholds was performed using an analgesiometer (Omnitech, Dartmouth, NS, Canada) as described previously (11,20). Pain thresholds were measured by the latency to limb shaking or paw lick with a maximum exposure time of 30 s. HP latency was averaged from three trials with 15-min intervals between each trial.…”

Section: Methodsmentioning

confidence: 99%

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Ketamine Reduces the Cell Death Following Inflammatory Pain in Newborn Rat Brain

et al. 2007

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Section: Repetitive Inflammatory Painsupporting

confidence: 53%

Section: Methodsmentioning

confidence: 99%

Ketamine Reduces the Cell Death Following Inflammatory Pain in Newborn Rat Brain

et al. 2007

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“…58 Animal studies have begun to investigate the mechanisms that underlie the deleterious effects of repeated or prolonged inflammatory pain resulting from invasive procedures. 52,[59][60][61][62][63] CURRENTLY AVAILABLE THERAPEUTIC OPTIONS Multiple classes of drugs have been evaluated for the prevention and management of neonatal pain and stress, including opioid analgesics, local anesthetics, general anesthetics, sedatives/hypnotics, nonsteroidal antiinflammatory drugs (NSAIDs), and sucrose. Although much research has been performed with these agents, many questions remain unanswered that prevent the optimal use of these drugs in clinical practice.…”

Section: Reasons To Consider Treatment Of Pain In Newborn Infantsmentioning

confidence: 99%

Summary Proceedings From the Neonatal Pain-Control Group

et al. 2006

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Recent advances in neurobiology and clinical medicine have established that the fetus and newborn may experience acute, established, and chronic pain. They respond to such noxious stimuli by a series of complex biochemical, physiologic, and behavioral alterations. Studies have concluded that controlling pain experience is beneficial with respect to short-term and perhaps long-term outcomes. Yet, pain-control measures are adopted infrequently because of unresolved scientific issues and lack of appreciation for the need for control of pain and its long-term sequelae during the critical phases of neurologic maturation in the preterm and term newborn. The neonatal pain-control group, as part of the Newborn Drug Development Initiative (NDDI) Workshop I, addressed these concerns. The specific issues addressed were (1) management of pain associated with invasive procedures, (2) provision of sedation and analgesia during mechanical ventilation, and (3) mitigation of pain and stress responses during and after surgery in the newborn infant. The cross-cutting themes addressed within each category included (1) clinical-trial designs, (2) drug prioritization, (3) ethical constraints, (4) gaps in our knowledge, and (5) future research needs. This article provides a summary of the discussions and deliberations. Full-length articles on procedural pain, sedation and analgesia for ventilated infants, perioperative pain, and study designs for neonatal pain research were published in Clinical Therapeutics (June 2005).www.pediatrics.org/cgi

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“…Recently, several authors have purposed detailed theories of how nociceptive stimuli modify central nervous system (Zelter et al 1997, Al-Chaer et al 2000, Ruda et al 2000, Bhutta et al 2001, Melzak et al 2001. Although it's known that precocious stimuli modulates sensitive pathways and response to pain later, the amount of injured tissue necessary to modulate such alterations is to discuss (Walker et al 2009).…”

Section: Introductionmentioning

confidence: 99%

“…Formalin tests have been used to simulate postoperatory inflammatory component and presents two phases: phase I with peak at 5 minutes mediated by local sensitive fibers; and phase II, about 15 minutes after injection, mediated by inflammatory mediators and non noxious sensitive fibers (Bhutta et al 2001, Hogan 2002, Ashmawi et al 2003.…”

Section: Introductionmentioning

confidence: 99%