Interactions of human chorionic gonadotropin with genotype and parity on fertility responses of lactating dairy cows

Zolini, Adriana Moreira; Ortiz, W.; Cortés, Eliab Estrada; Ortega, M. Sofía; Dikmen, Serdal; Sosa, Froylan; Giordano, J.O.; Hansen, P. J.

doi:10.3168/jds.2018-15358

Cited by 24 publications

(16 citation statements)

References 37 publications

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“…We also found that cows with the COQ9 genotype AG had the lowest SPC, and that genotypes AA and GG were not associated with any parameter analyzed. In a human chorionic gonadotropin stimulation study, Zolini et al (2019) found that cows with COQ9 genotype AG had the highest pregnancy rates at 30 and 60 days after artificial insemination, whereas those with genotype AA had the lowest pregnancy rate. Ortega et al (2017) found that cows with COQ9 genotype AA had lower SPC, and DO values, a higher pregnancy rate and more efficient mitochondrial function.…”

Section: Discussionmentioning

confidence: 99%

“…(2017) found that cows with COQ9 genotype AA had lower SPC, and DO values, a higher pregnancy rate and more efficient mitochondrial function. These cows produced higher concentrations of adenosine triphosphate, which intensifies the cellular response to hormone stimulation, triggering the release of prostaglandins and subsequent lysis of the corpus luteum ( Zolini et al., 2019 ). The differences in genotype behavior may be due to particular effects of dominance or heterosis in each population ( Khayatzadeh et al., 2018 ), whereas the influence of allele A is constant and independent of genotype.…”

Section: Discussionmentioning

confidence: 99%

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Effect of COQ9 and STAT5A polymorphisms on reproductive performance in a Holstein cow herd in Mexico

et al. 2020

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Coenzyme Q9 (COQ9), a coenzyme Q (CoQ) precursor, is an essential component of the mitochondrial electron transport chain that drives adenosine triphosphate production. COQ9 polymorphism 18:25527339 is characterized by substitution of guanine (allele G) for adenine (allele A), which modifies the function of the protein encoded by the gene. In Holsteins, allele A has been associated with better reproductive performance in terms of the conception rate, number of services per conception (SPC) and days open (DO). The signal transducer and activator of transcription (STAT) protein is a transcription factor activated in the presence of cytokines and growth factors. STAT5A polymorphism 19:42407732 in exon 8 has been associated with higher fertility and embryonic survival rates. The objective of this study was to determine the relationship of COQ9 and STAT5A polymorphisms with reproductive parameters [calving to first heat interval (CFHI), DO and SPC]. Blood samples were taken from 112 lactating Holstein from a herd in México for allele genotyping by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). To estimate the association between reproductive parameters and genotypes, a linear mixed-effect model was performed. The COQ9 AG genotype was associated significantly with lower SPC (P<0.05) but not with DO or CFHI. No significant association with any reproductive parameter was found for STAT5A. Our findings suggest that the COQ9 18:25527339 polymorphism is a useful molecular marker for improvement of reproductive performance in dairy herds.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of COQ9 and STAT5A polymorphisms on reproductive performance in a Holstein cow herd in Mexico

et al. 2020

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“…It is also possible, therefore, that the SNP affects sperm function. Recent results also failed to find a relationship between the PARM1 SNP and fertility in lactating dairy cows [41].…”

Section: Discussionmentioning

confidence: 99%

Importance of prostate androgen-regulated mucin-like protein 1 in development of the bovine blastocyst

2019

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Background Prostate androgen-regulated mucin-like protein 1 (PARM1) is a pro-proliferative and anti-apoptotic glycoprotein involved in the endoplasmic reticulum (ER) stress response. A single nucleotide polymorphism in the coding region of PARM1 has been associated with competence of bovine embryos to develop to the blastocyst stage. Here we tested the importance of PARM1 for development by evaluating consequences of reducing PARM1 mRNA abundance on embryonic development and differentiation, gene expression and resistance to ER stress. Results Knockdown of PARM1 using an anti- PARM1 GapmeR did not affect competence of embryos to develop into blastocysts but decreased the number of trophectoderm (TE) cells in the blastocyst and tended to increase the number of cells in the blastocyst inner cell mass (ICM). Treatment of embryos with anti- PARM1 GapmeR affected expression of 4 and 3 of 90 genes evaluated at the compact-morula and blastocyst stage of development at days 5.5 and 7.5 after fertilization, respectively. In morulae, treatment increased expression of DAB2, INADL, and STAT3 and decreased expression of CCR2 . At the blastocyst stage, knockdown of PARM1 increased expression of PECAM and TEAD4 and decreased expression of CCR7. The potential role of PARM1 in ER stress response was determined by evaluating effects of knockdown of PARM1 on development of embryos after exposure to heat shock or tunicamycin and on expression of ATF6 , DDIT3 and EIF2AK3 at the compact morula and blastocyst stages. Both heat shock and tunicamycin reduced the percent of embryos becoming a blastocyst but response was unaffected by PARM1 knockdown. Similarly, there was no effect of knockdown on steady-state amounts of ATF6 , DDIT3 or EIF2AK3. Conclusion PARM1 participates in formation of TE and ICM cells in early embryonic development but there is no evidence for the role of PARM1 in the ER stress response. Electronic supplementary material The online version of this article (10.1186/s12861-019-0195-7) contains supplementary material, which is available to authorized users.

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“…Presenta actividad FSH (Patron-Collantes et al, 2017) por lo tanto, durante la esteroidogénesis ovárica de rumiantes (fase folicular), estimula en células de la granulosa, la biosíntesis de E2, y el crecimiento folicular en ovarios inactivos, donde se puede utilizar para un protocolo de superovulación (Abdel-Khalek et al, 2018). La gonadotropina coriónica humana (hCG) es una glucoproteína (figura 5.5), producida durante el embarazo de la mujer, por el embrión y posteriormente obtenida de la placenta (Zolini et al, 2019). Presenta actividad LH (Besbaci et al, 2020) por lo tanto, durante la esteroidogénesis ovárica de rumiantes (fase lútea), estimula la biosíntesis de P4 (Willmore & Davis, 2019).…”

Section: Manipulación Hormonal Del Ciclo Reproductivounclassified

Sustentabilidad, Turismo y Educación TII

Gutiérrez¹

2020

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©ECORFAN-México, S.C.Ninguna parte de este escrito amparado por la Ley Federal de Derechos de Autor, podrá ser reproducida, transmitida o utilizada en cualquier forma o medio, ya sea gráfico, electrónico o mecánico, incluyendo, pero sin limitarse a lo siguiente: Citas en artículos y comentarios bibliográficos de compilación de datos periodísticos radiofónicos o electrónicos. Para los efectos de los artículos 13, 162,163 fracción I, 164 fracción I, 168, 169,209 fracción III y demás relativos de la Ley Federal de Derechos de Autor. Violaciones: Ser obligado al procesamiento bajo ley de copyright mexicana. El uso de nombres descriptivos generales, de nombres registrados, de marcas registradas, en esta publicación no implican, uniformemente en ausencia de una declaración específica, que tales nombres son exentos del protector relevante en leyes y regulaciones de México y por lo tanto libre para el uso general de la comunidad científica internacional. HSTE es parte de los medios de ECORFAN (www.ecorfan.org

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Interactions of human chorionic gonadotropin with genotype and parity on fertility responses of lactating dairy cows

Cited by 24 publications

References 37 publications

Effect of COQ9 and STAT5A polymorphisms on reproductive performance in a Holstein cow herd in Mexico

Effect of COQ9 and STAT5A polymorphisms on reproductive performance in a Holstein cow herd in Mexico

Importance of prostate androgen-regulated mucin-like protein 1 in development of the bovine blastocyst

Sustentabilidad, Turismo y Educación TII

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