Interactions of Cationic/Anionic Mixed Surfactant Aggregates with Phospholipid Vesicles and Their Skin Penetration Ability

Abstract

This work studied the interactions of an oppositely charged surfactant mixture of oleyl bis(2-hydroxyethyl)methyl ammonium bromide (OHAB) and sodium dodecyl sulfate (SDS) with 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine (DOPC) vesicles as well as the penetration of the OHAB/SDS mixture through model skin, aimed at understanding the relationship between the ability of different surfactant aggregates in solubilizing phospholipid vesicles and their potential in irritating skin. By changing the molar fraction of OHAB (X), five kinds of aggregates are constructed: OHAB and SDS separately form cationic and anionic small micelles, whereas the OHAB/SDS mixtures form cationic and anionic vesicles at X = 0.30 and 0.70, respectively, and weakly charged vesicles at X = 0.50. The mixtures have much lower critical micellar concentrations (CMCs) and much larger aggregates than either OHAB or SDS alone, and the CMC and the size of the OHAB/SDS vesicles decrease with the increase in X. The phase diagrams indicate that the OHAB/SDS mixtures show much stronger ability in solubilizing the DOPC vesicles than individual OHAB and SDS and decrease in the order of X = 0.30 > 0.50 > 0.70 ≫ 1.00 > 0. However, the ability of the surfactants in penetrating the model skin decreases reversely, and the penetration of the surfactants are significantly reduced by mixing. These results indicate that the surfactant mixture with a larger aggregate size and a smaller CMC value displays much stronger ability in solubilizing the DOPC vesicles but much weaker ability in penetrating the skin.

<p>Use of transethosomes for enhancing the transdermal delivery of olmesartan medoxomil: in vitro, ex vivo, and in vivo evaluation</p>

“…Consequently, the cone-shaped SAA generates perturbation to the closely packed lipid bilayers resulting in reduction of the PS. 43 It was also observed from the results that the PS was in accordance with the amount of drug entrapped into the vesicles. Therefore, the decrease in EE% would give another explanation for the lower PS of vesicles.…”

Equilibrium and Dynamic Surface Properties of Cationic/Anionic Surfactant Mixtures Based on Carboxylate Gemini Surfactant

“…(Cirin et al, 2017;Liu et al, 2016;Zhang et al, 2017b). Among these surfactant mixtures, researches have paid more attention to the cationic/anionic surfactant mixtures due to the strongest interaction between the oppositely charged hydrophilic head groups (Chen et al, 2017;Wang et al, 2016aWang et al, , 2016bWang et al, , 2016c.…”

Phase Behavior and Aggregation in a Catanionic System Dominated by an Anionic Surfactant Containing a Large Rigid Group

“…The strong electrostatic interactions between the oppositely charged head groups and the synergistic effects existing in aqueous mixtures of cationic and anionic surfactants endow the solutions with intriguing interfacial properties, such as low critical micelle concentration, low surface tension, and high foaming ability . By adjusting the composition of the cationic or anionic surfactants, abundant aggregates, such as rod‐ and worm‐like micelles, fibers, vesicles, and lamellar micelles, can be formed . Thus, aqueous solutions of catanionic surfactants can show various phase behaviors, such as viscoelastic solutions, aqueous surfactant two‐phase systems (ASTPs), aqueous surfactant three‐phase systems (AS3Ps), and liquid crystals (LCs) .…”

“…[7][8][9] By adjusting the composition of the cationic or anionic surfactants, abundant aggregates, such as rod-and worm-like micelles, fibers, vesicles, and lamellar micelles, can be formed. [10][11][12][13] Thus,a queous solutionso fc atanionic surfactants can show variousp hase behaviors,s uch as viscoelastic solutions, aqueous surfactant twophase systems (ASTPs), aqueous surfactant three-phase systems (AS3Ps), and liquid crystals (LCs). [6,[10][11][12][13][14][15][16] Sometimes, uniquea nd abundant phase behaviors can be obtained in a single system of catanionic surfactants only by changing the concentration or the ratio of the cationic and anionic surfactants.…”

“…[10][11][12][13] Thus,a queous solutionso fc atanionic surfactants can show variousp hase behaviors,s uch as viscoelastic solutions, aqueous surfactant twophase systems (ASTPs), aqueous surfactant three-phase systems (AS3Ps), and liquid crystals (LCs). [6,[10][11][12][13][14][15][16] Sometimes, uniquea nd abundant phase behaviors can be obtained in a single system of catanionic surfactants only by changing the concentration or the ratio of the cationic and anionic surfactants. [1,2] Among the variousphases observed in mixtures of catanionic surfactants,t he viscoelastic solutionh as distinctive rheological properties, which can be attributed to its microstructure, namely worm-like micelles.…”