Interactions of Amino-Containing Peptides with Sodium Silicate and Colloidal Silica:  A Biomimetic Approach of Silicification

Coradin, Thibaud; Durupthy, Olivier; Livage, Jacques

doi:10.1021/la011106q

Cited by 268 publications

(256 citation statements)

References 34 publications

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“…[49][50][51] Because the majority of the charged species on KSL are the primary amines of lysines, the biomineralization mechanism of KSL most likely follows other polyamine systems. Binding between silica groups and the amide side chains of KSL would leave the remaining phenylalanines and valines exposed to solvent, thereby rendering the surface of peptide-coated composite hydrophobic.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Bioinorganic Antimicrobial Peptide Nanoparticles with Potential Therapeutic Properties

2008

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Amphiphilicity and cationicity are properties shared between antimicrobial peptides and proteins that catalyze biomineralization reactions. Merging these two functionalities, we demonstrate a reaction where a cationic antimicrobial peptide catalyzes self-biomineralization within inorganic matrices. The resultant antimicrobial peptide nanoparticles retain biocidal activity, protect the peptide from proteolytic degradation, and facilitate a continuous release of the antibiotic over time. Taken together, these properties demonstrate the therapeutic potential of selfsynthesizing biomaterials that retain the biocidal properties of antimicrobial peptides.

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Section: Resultsmentioning

confidence: 99%

Synthesis of Bioinorganic Antimicrobial Peptide Nanoparticles with Potential Therapeutic Properties

2008

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“…The use of highly methylated propylamines by diatoms or nonmethylated propylamines by sponges could therefore be a serendipitous use of an already existing biosynthetic precursor route, or perhaps there is something specific about the chemical nature of the propylamines that makes them ideal for use in the building of structures in these species. Many experimental studies have attempted to identify the effects of short amines on silicification but these studies have generally focused on a single structural characteristic of the amines in isolation, such as chain length or degree of polymerization (16)(17)(18)(19)(20)(21)(22)(23). Here, to more fully assess the role of amine structure in silicification, we have looked at three key structural features: (i) the degree of polymerization, (ii) the level of amine methylation, and (iii) the length of the amine chain spacers.…”

mentioning

confidence: 99%

From biosilicification to tailored materials: Optimizing hydrophobic domains and resistance to protonation of polyamines

Belton

Patwardhan

Annenkov

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

131

181

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Considerable research has been directed toward identifying the mechanisms involved in biosilicification to understand and possibly mimic the process for the production of superior silica-based materials while simultaneously minimizing pollution and energy costs. Molecules isolated from diatoms and, most recently sponges, thought to be key to this process contain polyamines with a propylamine backbone and variable levels of methylation. In a chemical approach to understanding the role of amine (especially propylamine) structures in silicification we have explored three key structural features: (i) the degree of polymerization, (ii) the level of amine methylation, and (iii) the size of the amine chain spacers. In this article, we show that there are two factors critical to their function: the ability of the amines to produce microemulsions and the presence of charged and uncharged amine groups within a molecule, with the latter feature helping to catalyze silicic acid condensation by a proton donor/acceptor mechanism. The understanding of amine-silicate interactions obtained from this study has enabled the controlled preparation of hollow and nonporous siliceous materials under mild conditions (circumneutral pH, room temperature, and in all aqueous systems) possibly compatible with the conditions used by biosystems. The ''rules'' identified from our study were further used predictively to modulate the activity of a given amine. We believe that the outcomes of the present contribution will form the basis for an approach to controlling the growth of inorganic materials by using tailor-made organic molecules.bioinspired materials ͉ biosilica ͉ hollow particles T he commercialization of siliceous materials has generated a multibillion pound industry with the value of precipitated silica products alone estimated to have reached 1.4 billion pounds by the year 2006 (1). This value largely depends on the ability to produce silica for specific applications through control of surface chemistry and morphology during the condensation and aggregation process. Industrial processes involved in the production of high-value siliceous materials typically involve harsh conditions of high temperature and acidity or basicity, environmentally damaging waste streams, and often toxic silicate precursors. These processes also generally exert poor chemical and morphological control over the materials produced. In comparison, natural silica production in organisms such as sponges, diatoms, and radiolaria occurs under biologically benign conditions and produces silica of exquisite form and function, all from a monosilicic acid source of only a few parts per million in concentration (2). Considerable research has been directed toward identifying the mechanisms involved in the biosilicification process to understand and possibly mimic the process to allow us to produce superior materials without the attendant pollution and high-energy usage (3, 4).Studies of the processes associated with the formation of siliceous diatom shells (thecae) have i...

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“…The choice of polymers was based on the known effect of cationic proteins and other cationic polymers in natural biosilicification. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] It is also known more generally in biomineralisation that auxiliary macromolecules play a rô le in controlling the structure of the growing mineral 1,2,23 and it was thus of interest to compare the behaviour of the quaternised PDMAEMA homopolymers with that of the DMAEMA-MMA block copolymers, where the PMMA block can potentially exert a non-catalytic auxiliary effect. It has further been shown that the hydrophobic PMMA block leads to self-assembly of the block copolymers in aqueous solution, 24 which allows the possible effect of using copolymer micelles with cationic coronas (rather than molecularly dissolved cationic polymers) on silica catalysis to be explored.…”

Section: Resultsmentioning

confidence: 99%

“…[1][2][3] Recently researchers have isolated the proteins responsible for silica precipitation and a number of proteins, polypeptides and synthetic polymers have been found to precipitate ordered and disordered silica structures from either tetraalkoxysilanes or sodium silicate. [3][4][5][6][7][8][9][10][11][12][13][14][15][16] It has been postulated that the more pronounced effect of peptides compared to amines is not just due to the many electrostatic interactions or hydrogen bonds available within the polymer but that the relative arrangement of the amino groups is also important. Within a single molecule the electrostatic and/or hydrogen bond interactions are not thought to be sufficient to favour condensation.…”

Section: Introductionmentioning

confidence: 99%

Use of quaternised methacrylate polymers and copolymers as catalysts and structure directors for the formation of silica from silicic acid

et al. 2005

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A range of quaternised tertiary amine methacrylate-based homopolymers and copolymers were synthesised as mimics of the biopolymers implicated in biosilica formation. These synthetic polymers were evaluated for their ability to catalyse and direct the structure of silica formed by condensation of silicic acid in aqueous solution and at neutral pH. Homo-and co-polymers of differing degrees of quaternisation were studied, while some of the homopolymers also differed in their chain length. All polymers acted as catalysts for the condensation reaction, but at different rates according to their architecture and degree of quaternisation. The resulting silica-polymer hybrids were characterised fully, as were pure silicas obtained by calcination of the hybrids. Some crystallites were present in the hybrids and differences in crystal structure were observed in the calcined silicas, depending on the structure of the polymer, indicating that the polymers exert a structure-directing effect during initial silica formation. The work provides some new insights into structural factors affecting silica growth catalysed by synthetic cationic polymers.

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Interactions of Amino-Containing Peptides with Sodium Silicate and Colloidal Silica: A Biomimetic Approach of Silicification

Cited by 268 publications

References 34 publications

Synthesis of Bioinorganic Antimicrobial Peptide Nanoparticles with Potential Therapeutic Properties

Synthesis of Bioinorganic Antimicrobial Peptide Nanoparticles with Potential Therapeutic Properties

From biosilicification to tailored materials: Optimizing hydrophobic domains and resistance to protonation of polyamines

Use of quaternised methacrylate polymers and copolymers as catalysts and structure directors for the formation of silica from silicic acid

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