Interactions between Ultrafine Particles and Transition Metals in Vivo and in Vitro

Wilson, Martin; Lightbody, Janet; Donaldson, Ken; Sales, Jill; Stone, Vicki

doi:10.1006/taap.2002.9501

Cited by 388 publications

(208 citation statements)

References 31 publications

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“…Since CNTs have been shown to cause ROS production independent of their interaction with mammalian cells (i.e., in a cell-free environment) [39], the CNTs used in the present study were assessed for their ROS production in both a cell-free environment and also following exposure to MDM. On both occasions, an adapted version of the protocol previously described by Wilson et al [49] and Foucard et al [50], the fluorescent probe 2′,7′-dichlorfluorecein-diacetate (DCFH 2 -DA) which is degraded by ROS, cleaving the molecule to DCF which subsequently elicits a fluorescent signal [51], was used. Furthermore, the compound horse-radish peroxidase was used to amplify any ROS signal present [43].…”

Section: Reactive Oxygen Species Productionmentioning

confidence: 99%

Assessing the impact of the physical properties of industrially produced carbon nanotubes on their interaction with human primary macrophages in vitro

et al. 2013

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Abstract:Currently it is not fully understood how carbon nanotubes (CNTs) may affect human health. Despite this, CNTs are produced at a tonne mass scale yearly. Due to their large production and intended use within a variety of applications it is imperative that a clear understanding of the hazard potential of CNTs is gained. The aim of this study therefore was to assess the impact of five different industrially produced CNTs which varied in their physical properties on the viability of human monocyte derived macrophages (MDM), and subsequently, at sub-lethal concentrations (0.005-0.02 mg/mL), their ability to cause oxidative stress and a pro-inflammatory response in these important immune cells over a 24-h period. None of the CNTs caused significant cytotoxicity up to 0.02 mg/mL after 24 h. Only the long multi-walled CNTs (MWNCTs) caused a significant, dose-dependent (0.005-0.02 mg/mL) reactive oxygen species production, whilst bundled MWCNTs showed a significant tumor necrosis factor alpha release after 24 h exposure at 0.02 mg/mL. No effects were observed for either tangled MWCNTs or short MWCNTs. It can be concluded from the findings of the present study that the industrially produced CNTs studied can cause hazardous effects in vitro that may be associated with their physical properties.

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Section: Reactive Oxygen Species Productionmentioning

confidence: 99%

Assessing the impact of the physical properties of industrially produced carbon nanotubes on their interaction with human primary macrophages in vitro

et al. 2013

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“…Even toxicological studies have shown that small nanoparticles (<100 nm) cause adverse respiratory health effects, causing more inflammation than larger particles made from the same material [76][77][78][79][80]. The body will react differently to the same mass dose consisting of billions of nanoparticles compared to several micro particles.…”

Section: Toxicity Of Selenium Nanoparticlesmentioning

confidence: 99%

Green Synthesis of Selenium Nanoparticles from Broccoli, Characterization, Application and Toxicity

Kapur¹,

Soni²,

Kohli³

2017

Adv Tech Biol Med

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Selenium in broccoliBroccoli belongs to the Brassicaceae family, originated in the Mediterranean regions and distributed in Europe and in the United States. Broccoli is rich in micronutrients such as carotene, vitamin C and folic acid-fibers, phytochemicals such as glucosinolates (GLs) and *Corresponding author: Kanchan Kohli, PhD, Associate Professor, Department of Pharmaceutics, Jamia Hamdard, Hamdard University, New Delhi 110062, India, Tel: +911126059688; E-mail: drkanchankohli@gmail.com AbstractPlant-based diets and phytochemicals present in plants can be used to decrease the risk of cancer. This article deals with Brassica species and broccoli in particular which are associated with reduced risk of several important cancers. These plants mainly contain selenium (Se) covalently bound in a number of different chemical forms which is mainly responsible for its biological activity. Further, several enzymes contain selenium in the form of the unusual selenocysteine amino acid which act on free radicals. Broccoli has the ability to accumulate Se many-fold beyond the concentration of Se present in the soil. Reflecting on the above it can be suggested that development of methods to increase the natural accumulation of Se in broccoli may greatly enhance its health-promoting properties. The present article details about green synthesis of selenium nanoparticles and their methods of characterizations. Green synthesis is a biological procedure which can be achieved can be achieved by using plant extracts. This method is capable of producing SeNPs in a size range of about 50-150 nm, under ambient conditions. It was found that SeNPs are able to inhibit the cell growth by dose-dependent manner. In addition, combination of SeNPs and doxorubicin shows better anticancer effect than individual treatments. The present review also brings to light about the causes and implications of toxic effects posed by Se nanoparticles as well as applications of Se nanoparticles in medicine.Green Synthesis of Selenium Nanoparticles from Broccoli, Characterization, Application and Toxicity Citation: Kapur M, Soni K, Kohli K (2017) Green Synthesis of Selenium Nanoparticles from Broccoli, Characterization, Application and Toxicity. Adv Tech Biol Med 5: 198. doi: 10.4172/2379-1764.1000198 Page 2 of 7 ManaviVolume Se Nanoparticles Characterization [42]An initial characterization of the test substance is imperative before any toxicity screening is commenced. A more extensive and complete characterization, including size distribution, shape, surface area, surface chemistry, crystallinity, porosity, agglomeration state, surface charge, solubility, etc., is recommended for nanomaterials in order to determine the correct correlation between their physicochemical properties and the biological effects they elicit [43][44][45][46].

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“…In the longer term, nanotechnology may help improve implants and even let blind people see. Nonetheless, governments must stimulate scientists to monitor possible health risks of nanoparticles that may accumulate in the body [14][15][16][17][18][19][20].…”

Section: Potential Risksmentioning

confidence: 99%

“…Lipid forms participate in lipid per oxidation reactions. Produced in the presence of oxygen by radical addition to double bonds or hydrogen abstraction [18].…”

Section: Ro• Alkoxy and Roo• Peroxy Radicalsmentioning

confidence: 99%

Review on a Nanomaterials Mechanisms-Induced Oxidative Stress and Toxicity

Geetha¹,

Prabhavathi²,

Ayeshamariam³

et al. 2017

J Powder Metall Min

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The review reveals the recent trends of nano-materials in biomedical applications and an overview to discuss the commercialization of nano-materials. Due to innovative ideas in nano-materials created a lot of new discoveries in the medical, consumer sectors and industrial applications. The properties of nano-materials lead to a quite interest in a various applications in biomedical field such as structural and physicochemical properties. In a biological activity; toxicities of a nanoparticle are frequently reported. In the presence of acellular factors such as size, composition, particle surface and presence of metals in a nano-materials induces oxidative stress and it creates a pathway for patho physiological effects includes fibrosis, genotoxicity and injuries in a skin. Zinc oxide acts as an antioxidant for reducing oxidative stress and it acts as a protective agent for an immune system in a biomedical fields. This review summarizes biomedical applications of a nano-materials and the role of an oxidative stress.

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Interactions between Ultrafine Particles and Transition Metals in Vivo and in Vitro

Cited by 388 publications

References 31 publications

Assessing the impact of the physical properties of industrially produced carbon nanotubes on their interaction with human primary macrophages in vitro

Assessing the impact of the physical properties of industrially produced carbon nanotubes on their interaction with human primary macrophages in vitro

Green Synthesis of Selenium Nanoparticles from Broccoli, Characterization, Application and Toxicity

Review on a Nanomaterials Mechanisms-Induced Oxidative Stress and Toxicity

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