Interactions Between Pharmaceutical Compounds by Thermal Methods

Guillory, J. Keith; Hwang, Soon C.; Lach, John L.

doi:10.1002/jps.2600580303

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Methods Of Determination Of Types Of Solid Dispersion Systems1

Pharmaceutical Aspects Of the Use Of Excipients1

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1969

2009

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Article9

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Cited by 55 publications

(18 citation statements)

References 26 publications

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“…It is time consuming, it requires a relatively large amount of sample, and changes in slopes can be missed, especially if cooling takes place rapidly (86). The temperature of the mixture is then recorded as a function of time.…”

Section: Methods Of Determination Of Types Of Solid Dispersion Systemsmentioning

confidence: 99%

Pharmaceutical Applications of Solid Dispersion Systems

Chiou

Riegelman

1971

Journal of Pharmaceutical Sciences

1,539

841

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Section: Methods Of Determination Of Types Of Solid Dispersion Systemsmentioning

confidence: 99%

Pharmaceutical Applications of Solid Dispersion Systems

Chiou

Riegelman

1971

Journal of Pharmaceutical Sciences

1,539

841

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“…The main aim of using these methods is to confirm the absence of chemical changes to molecules resulting from physical interactions [41]. Reductions in the quantitative content of the active ingredient due to physical interactions between a substance and microcrystalline cellulose serves as an example of such a negative effect [42].…”

Section: Pharmaceutical Aspects Of the Use Of Excipientsmentioning

confidence: 99%

The role of excipients in determining the pharmaceutical and therapeutic properties of medicinal agents (Review)

2009

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The effects of pharmaceutical excipients on the quality of medicinal products are discussed. It is emphasized that excipients must be studied before the development of a product starts, including compliance with production standards, investigations of their influences on the physical, pharmacological, and microbiological characteristics of products, and influences on the therapeutic efficacy and safety of medicinal formulations (release of active ingredient, bioavailability, etc.). Aspects considered in the present review indicate the need for a wide approach to assessment of the roles of excipients in determining the required pharmaceutical and therapeutic properties of medicinal products.

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“…La thermomicroscopie [l, 2], l'analyse thermique diff6rentielle [3] et l'analyse calorim6trique diff6rentielle [4] constituent, /a l'heure actuelle, les principales m6thodes thermiques d'6tude des m61anges m6dicamenteux.…”

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