Interactions between oestrogen and 1α,25(OH)2-vitamin D3 signalling and their roles in spermatogenesis and spermatozoa functions

Zanatta, Ana Paula; Brouard, Vanessa; Gautier, Camille; Gonçalves, Renata; Bouraïma-Lelong, Hélène; Silva, Fátima Regina Mena Barreto; Delalande, Christelle

doi:10.1186/s12610-017-0053-z

Cited by 16 publications

(10 citation statements)

References 180 publications

(221 reference statements)

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“…It should be noted that both estrogen and progesterone could affect TBI-induced damage [34]. Previous studies have demonstrated the interactions between estrogen and VD in human umbilical artery vascular smooth muscle cells and spermatozoa functions [35, 36]. Moreover, a combination of calcitriol and progesterone can improve pathological outcomes after TBI, with a varying response to the calcitriol dose [11].…”

Section: Discussionmentioning

confidence: 99%

Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury

Chen

Feng

Cui

et al. 2017

Cell Physiol Biochem

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Background/Aims: Traumatic brain injury (TBI) is a major public health problem in the world and causes high rates of mortality and disability. Recent evidence suggests that vitamin D (VD) has neuroprotective actions and can promote function recovery after TBI. In vitro and in vivo studies have demonstrated that autophagy could be enhanced following supplementation with an active metabolite of VD (calcitriol). However, it is unclear whether autophagy participates in the protective effects of calcitriol after TBI. To test this hypothesis, we examined the protective effects of calcitriol on TBI-induced neurological impairment and further investigated whether calcitriol could modulate autophagy dysfunction-mediated cell death in the cortex region of rat brain. Methods: Eighty-five male rats (250-280 g) were randomly assigned to sham (n=15), TBI model (TBI, n=35) and calcitriol treatment (calcitriol, n=35) groups. Rats were injected intraperitoneally with calcitriol (1 µg/kg) at 30 min, 24 h and 48 h post-TBI in the calcitriol group. The lysosomal inhibitor, chloroquine (CQ), was used to evaluate autophagic flux in the TBI and calcitriol groups. Neurological functions were evaluated via the modified neurological severity score test at 1-7 days after TBI or sham operation, and the terminal deoxynucleotidyl transferase-mediated FITC-dUTP nick-end labeling method was used to evaluate the ability of calcitriol to inhibit apoptosis. The expression of VDR, LC3 and p62 proteins was measured by western blot analysis at 1, 3 and 7 days post-injury Results: Calcitriol treatment attenuated mNSS at 2-7 days post-TBI (P < 0.05 versus TBI group). Calcitriol dramatically increased VDR protein expression compared with the untreated counterparts at 1, 3 and 7 days post-TBI (P < 0.05). The rate of apoptotic cells in calcitriol-treated rats was significantly reduced compared to that observed in the TBI group (P < 0.05). The LC3II/LC3I ratio was decreased in the cortex region at 1, 3 and 7 days post-TBI in rats treated with calcitriol (p < 0.05 versus TBI group), and the p62 expression was also attenuated (p < 0.05 versus TBI group). The LC3II/LC3I ratio in the calcitriol group was significantly increased when pretreated with CQ (P < 0.05). Conclusion: Calcitriol treatment activated VDR protein expression and attenuated neurological deficits in this rat TBI model. The protective effects might be associated with the restoration of autophagy flux and the decrease in apoptosis in the cortex region of rat brain.

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Section: Discussionmentioning

confidence: 99%

Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury

Chen

Feng

Cui

et al. 2017

Cell Physiol Biochem

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“…Human spermatozoa contain all the necessary machinery for its actions, including the VD receptor and VD metabolizing enzymes, the expression of which in human spermatozoa serve as positive predictive markers of sperm quality, with both genomic and non-genomic actions operating there [ 19 – 21 ]. Since both VD receptors and estradiol receptors are present in spermatozoa, an interaction between estrogen and VD signalling occurs there, as shown in a recent review [ 22 ]. Surprisingly, there seems to be no data on VD concentrations in seminal plasma, in contrast to numerous reports on blood serum levels [ 23 ], though it might be an interesting marker of male reproductive function.…”

Section: Other Steroids In Seminal Plasmamentioning

confidence: 99%

Occurrence and reproductive roles of hormones in seminal plasma

Vítků

Kolátorová

Hampl

2017

Basic Clin. Androl.

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Only 2–5% of seminal fluid is composed of spermatozoa, while the rest is seminal plasma. The seminal plasma is a rich cocktail of organic and inorganic compounds including hormones, serving as a source of nutrients for sperm development and maturation, protecting them from infection and enabling them to overcome the immunological and chemical environment of the female reproductive tract. In this review, a survey of the hormones found in human seminal plasma, with particular emphasis on reproductive hormones is provided. Their participation in fertilization is discussed including their indispensable role in ovum fertilization. The origin of individual hormones found in seminal plasma is discussed, along with differences in the concentrations in seminal plasma and blood plasma. A part of review is devoted to methods of measurement, emphasising particular instances in which they differ from measurement in blood plasma. These methods include separation techniques, overcoming the matrix effect and current ways for end-point measurement, focusing on so called hyphenated techniques as a combination of chromatographic separation and mass spectrometry. Finally, the informative value of their determination as markers of male fertility disorders (impaired spermatogenesis, abnormal sperm parameters, varicocele) is discussed, along with instances where measuring their levels in seminal plasma is preferable to measurement of levels in blood plasma.

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“…The function of ERp57/PDIA3 in sperm capacitation can be hypothesized to be related to its interaction with vitamin D 3 [ 124 , 125 ]. In fact, it should pointed out that several functions of spermatozoa, such as viability, integrity of DNA, motility, capacitation, acrosome reaction, and fertilizing capability, are targets of the action of hormones, including estrogens and 1α,25(OH)2D3 [ 126 ].…”

Section: High-impact Information On Erp57/pdia3 (Ligand)mentioning

confidence: 99%

ERp57/PDIA3: new insight

et al. 2022

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The ERp57/PDIA3 protein is a pleiotropic member of the PDIs family and, although predominantly located in the endoplasmic reticulum (ER), has indeed been found in other cellular compartments, such as the nucleus or the cell membrane. ERp57/PDIA3 is an important research target considering it can be found in various subcellular locations. This protein is involved in many different physiological and pathological processes, and our review describes new data on its functions and summarizes some ligands identified as PDIA3-specific inhibitors.

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Interactions between oestrogen and 1α,25(OH)2-vitamin D3 signalling and their roles in spermatogenesis and spermatozoa functions

Cited by 16 publications

References 180 publications

Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury

Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury

Occurrence and reproductive roles of hormones in seminal plasma

ERp57/PDIA3: new insight

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