Interactions between magnetic nanoparticles and model lipid bilayers—Fourier transformed infrared spectroscopy (FTIR) studies of the molecular basis of nanotoxicity

Kręcisz, Monika; Rybka, Jakub Dalibor; Strugała, Aleksander; Skalski, Bohdan; Figlerowicz, M.; Kozak, Maciej; Giersig, Michael

doi:10.1063/1.4962951

Cited by 22 publications

(11 citation statements)

References 44 publications

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“…Despite the advantages of iron oxide particles, their toxicity and nanotoxicity [17] is one of the main problems for their in vivo application. The results of several studies showed that the accumulation of iron ions causes neuronal damage in the brain and inhibits the synthesis of proteins associated with the growth of neural cells [18, 19].…”

Section: Introductionmentioning

confidence: 99%

Composite spheres made of bioengineered spider silk and iron oxide nanoparticles for theranostics applications

et al. 2019

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Bioengineered spider silk is a biomaterial that has exquisite mechanical properties, biocompatibility, and biodegradability. Iron oxide nanoparticles can be applied for the detection and analysis of biomolecules, target drug delivery, as MRI contrast agents and as therapeutic agents for hyperthermia-based cancer treatments. In this study, we investigated three bioengineered silks, MS1, MS2 and EMS2, and their potential to form a composite material with magnetic iron oxide nanoparticles (IONPs). The presence of IONPs did not impede the self-assembly properties of MS1, MS2, and EMS2 silks, and spheres formed. The EMS2 spheres had the highest content of IONPs, and the presence of magnetite IONPs in these carriers was confirmed by several methods such as SEM, EDXS, SQUID, MIP-OES and zeta potential measurement. The interaction of EMS2 and IONPs did not modify the superparamagnetic properties of the IONPs, but it influenced the secondary structure of the spheres. The composite particles exhibited a more than two-fold higher loading efficiency for doxorubicin than the plain EMS2 spheres. For both the EMS2 and EMS2/IONP spheres, the drug revealed a pH-dependent release profile with advantageous kinetics for carriers made of the composite material. The composite spheres can be potentially applied for a combined cancer treatment via hyperthermia and drug delivery.

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Section: Introductionmentioning

confidence: 99%

Composite spheres made of bioengineered spider silk and iron oxide nanoparticles for theranostics applications

et al. 2019

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“…The residual weight of blank liposomes was 10.3% ( w / w ) at the end of temperature increase to 650 °C. In comparison, MLs displayed a similar decomposition peak, temperature, but the shoulder temperature transformed into a more distinctive peak temperature possibly due to the interactions of lipids with CMNPs [ 48 ]. From the residual weight difference between MLs and blank liposomes at 650 °C, the weight percentage of CMNPs in MLs was estimated to be ~21.0% ( w / w ), assuming negligible weight loss for CMNPs, which compared favorably with that obtained from chemical analysis (21.8% ± 1.7%).…”

Section: Resultsmentioning

confidence: 99%

Optimization of the Preparation of Magnetic Liposomes for the Combined Use of Magnetic Hyperthermia and Photothermia in Dual Magneto-Photothermal Cancer Therapy

Anilkumar

Chen

2020

IJMS

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In this work, we aimed to develop liposomal nanocomposites containing citric-acid-coated iron oxide magnetic nanoparticles (CMNPs) for dual magneto-photothermal cancer therapy induced by alternating magnetic field (AMF) and near-infrared (NIR) lasers. Toward this end, CMNPs were encapsulated in cationic liposomes to form nano-sized magnetic liposomes (MLs) for simultaneous magnetic hyperthermia (MH) in the presence of AMF and photothermia (PT) induced by NIR laser exposure, which amplified the heating efficiency for dual-mode cancer cell killing and tumor therapy. Since the heating capability is directly related to the amount of entrapped CMNPs in MLs, while the liposome size is important to allow internalization by cancer cells, response surface methodology was utilized to optimize the preparation of MLs by simultaneously maximizing the encapsulation efficiency (EE) of CMNPs in MLs and minimizing the size of MLs. The experimental design was performed based on the central composite rotatable design. The accuracy of the model was verified from the validation experiments, providing a simple and effective method for fabricating the best MLs, with an EE of 87% and liposome size of 121 nm. The CMNPs and the optimized MLs were fully characterized from chemical and physical perspectives. In the presence of dual AMF and NIR laser treatment, a suspension of MLs demonstrated amplified heat generation from dual hyperthermia (MH)–photothermia (PT) in comparison with single MH or PT. In vitro cell culture experiments confirmed the efficient cellular uptake of the MLs from confocal laser scanning microscopy due to passive accumulation in human glioblastoma U87 cells originated from the cationic nature of MLs. The inducible thermal effects mediated by MLs after endocytosis also led to enhanced cytotoxicity and cumulative cell death of cancer cells in the presence of AMF–NIR lasers. This functional nanocomposite will be a potential candidate for bimodal MH–PT dual magneto-photothermal cancer therapy.

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“…Toxicity and cytotoxicity of SPIONs is strongly dependent on their size, type of coating and concentration. 61 In several studies, a wide range of surface coatings have been tested to prove that toxic effects of SPIONs can be diminished to a great extent. 62 The mechanism of cellular uptake is determined by particles' size and coating.…”

Section: Biological Propertiesmentioning

confidence: 99%

Radiosensitizing properties of magnetic hyperthermia mediated by superparamagnetic iron oxide nanoparticles (SPIONs) on human cutaneous melanoma cell lines

Rybka

2019

Reports of Practical Oncology & Radiotherapy

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Melanoma is responsible for the majority of deaths related to skin cancer. Worryingly, prognoses show an increasing number of melanoma cases each year worldwide. Radiotherapy, which is a cornerstone of cancer treatment, has proved to be useful but insufficient in melanoma management due to exceptionally high radioresistance of melanoma cells. This problem could be overcome by superparamagnetic iron oxide nanoparticles (SPIONs) used as heat mediators in magnetic hyperthermia, which not only enhance radiosensitivity, but also enable precise targeting by exploitation of their magnetic properties.

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Interactions between magnetic nanoparticles and model lipid bilayers—Fourier transformed infrared spectroscopy (FTIR) studies of the molecular basis of nanotoxicity

Cited by 22 publications

References 44 publications

Composite spheres made of bioengineered spider silk and iron oxide nanoparticles for theranostics applications

Composite spheres made of bioengineered spider silk and iron oxide nanoparticles for theranostics applications

Optimization of the Preparation of Magnetic Liposomes for the Combined Use of Magnetic Hyperthermia and Photothermia in Dual Magneto-Photothermal Cancer Therapy

Radiosensitizing properties of magnetic hyperthermia mediated by superparamagnetic iron oxide nanoparticles (SPIONs) on human cutaneous melanoma cell lines

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