Interactions Between Life Stressors and Susceptibility Genes (5-HTTLPR and BDNF) on Depression in Korean Elders

Kim, Jae-Min; Stewart, Robert; Kim, Sung‐Wan; Yang, Su-Jin; Shin, Il‐Seon; Kim, Young-Hoon; Yoon, Jin‐Sang

doi:10.1016/j.biopsych.2006.11.020

Cited by 252 publications

(209 citation statements)

References 45 publications

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“…124 Two 5-HTTLPR G Â E studies with samples at the extremes of the age span have reported a three-way interaction between environmental adversity, the 5-HTTLPR and BDNF val66met polymorphism. 31,32 In both cases, the three-way interaction including BDNF was stronger than the two-way interaction of SLE with 5-HTTLPR. The BDNF genotype was not included in the other 5-HTTLPR G Â E studies, and to our knowledge, no negative findings have been reported so far.…”

Section: Serotonin Transporter Gene-environment Interaction R Uher Anmentioning

confidence: 87%

“…15 Of the four studies with predominantly middle-aged to elderly samples, two showed no evidence of interaction with the non-significant interaction signs pointing in the opposite direction; 44,45 one identified an interaction in the expected direction for female participants only, 41 and one in the whole sample after correcting for gender. 32 The observed pattern of variation by age and gender is likely to reflect several interacting factors. Depression is more common in females.…”

Section: Methodsmentioning

confidence: 99%

“…However, no such direct association was reported in the older samples. 32,41,44,45 Therefore, the alternative explanation should be considered that the 5-HTTLPR genotype-mediated vulnerability operates in a developmental period comprising young adulthood.…”

Section: Methodsmentioning

confidence: 99%

“…Taken at face value, there were eleven replications, 15,[29][30][31][32][33][34][35][36][37][38][39] three partial replications in females only, [40][41][42] and three non-replications. [43][44][45] Importantly, two studies with very large samples were negative.…”

Section: Human Studiesmentioning

confidence: 99%

“…29,35 A study in elderly Korean sample found G Â E results consistent with dominant s allele. 32 Some authors assumed a dominant s based on an early 5-HTT expression study and did not report results separately for heterozygotes. 41 On the other hand, Kendler and colleagues 15 found that a model with recessive s (that is with ll and ls combined) provided best fit to their data and at least one other study showed results consistent with recessive s. 34 Results from child and adolescent samples place heterozygotes intermediate but close to ll homozygotes, suggesting a predominantly recessive s effect for early-onset depression.…”

Section: Allelic Variants Of 5-httlpr: L a And L G Or Rs25531mentioning

confidence: 99%

See 4 more Smart Citations

The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis

2007

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Section: Serotonin Transporter Gene-environment Interaction R Uher Anmentioning

confidence: 87%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Human Studiesmentioning

confidence: 99%

Section: Allelic Variants Of 5-httlpr: L a And L G Or Rs25531mentioning

confidence: 99%

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The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis

2007

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The Serotonin Transporter Promoter Variant (5-HTTLPR), Stress, and Depression Meta-analysis Revisited

Karg¹,

Burmeister²,

Shedden³

et al. 2011

Arch Gen Psychiatry

1,251

1,081

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Context The initial report of an interaction between a serotonin transporter promoter polymorphism (5-HTTLPR) and stress in the development of depression is perhaps the best-known and most cited finding in psychiatric genetics. Two recent meta-analyses explored the studies seeking to replicate this initial report and concluded that the evidence did not support the presence of the interaction. However, even the larger of the meta-analyses included only 14 of the 56 studies that have explored the relationship between 5-HTTLPR, stress and depression. Objective We sought to perform a meta-analysis including all relevant studies assessing whether 5-HTTLPR moderates the relationship between stress and depression. Data Sources We identified relevant articles from previous meta-analyses and reviews and a PubMed database search. Study Selection We excluded two studies presenting data that were included in other, larger, studies already included in our meta-analysis to avoid duplicate counting of subjects. Data Extraction In order to perform a more inclusive meta-analysis, we used the Liptak-Stouffer Z-score method to combine findings of primary studies at the significance test level rather than raw data level. Results We included 54 studies and found strong evidence that 5-HTTLPR moderates the relationship between stress and depression, with the 5-HTTLPR s allele associated with an increased risk of developing depression under stress (p<0.0001). When restricting our analysis to the studies included in the previous meta-analyses, we found no evidence of association (Munafo studies p=0.16; Risch studies p=0.11). This suggests that the difference in results between previous meta-analyses and ours was not due to the difference in meta-analytic technique but instead to the expanded set of studies included in this analysis. Conclusions Contrary to the results of the smaller earlier meta-analyses, we find strong evidence that 5-HTTLPR moderates the relationship between stress and depression in the studies published to date.

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Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression

Risch¹,

Herrell²,

Lehner³

et al. 2009

JAMA

1,532

1,167

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Interactions Between Life Stressors and Susceptibility Genes (5-HTTLPR and BDNF) on Depression in Korean Elders

Cited by 252 publications

References 45 publications

The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis

The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis

The Serotonin Transporter Promoter Variant (5-HTTLPR), Stress, and Depression Meta-analysis Revisited

Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression

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