Interactions between insulin-like growth factor-I (IGF-I) and the renin-angiotensin system in follicular growth and ovulation.

Yoshimura, Yasunori; Aoki, Nobumitsu; Sueoka, Kou; Miyazaki, Toshihisa; Kuji, Naoaki; Tanaka, Mamoru; Kobayashi, Toshifumi

doi:10.1172/jci118794

Cited by 27 publications

(20 citation statements)

References 49 publications

(75 reference statements)

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“…We have demonstrated that IGF-I stimulates the meiotic maturation of rabbit follicle-enclosed oocytes in the absence of gonadotropin in a dose-dependent manner [10,11]. This finding is consistent with previous d ata showin g t hat IGF-I enha nced t he mei otic maturation of cumulus-enclosed oocytes in humans [12].…”

Section: Factors Affecting Oocyte Maturationsupporting

confidence: 91%

Oocyte Maturation in Humans: the Potential Relevance to Reproductive Medicine

Yoshimura

2003

J.Mamm.Ova.Res.

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Section: Factors Affecting Oocyte Maturationsupporting

confidence: 91%

Oocyte Maturation in Humans: the Potential Relevance to Reproductive Medicine

Yoshimura

2003

J.Mamm.Ova.Res.

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“…Alternatively, FSHi may exert its antagonistic effects by increasing the intracellular levels of protein kinase A inhibitors, which have not been yet isolated from ovarian granulosa cells but that may inhibit cAMP-dependent phosphorylation in a variety of tissues, including rat Sertoli cells [41, 42, 43]. On the other hand, FSHi may inhibit the FSH-stimulated actions indirectly by increasing the amounts of insulin-like growth factor binding proteins, which have been shown to act as potent inhibitors of some specific gonadotropin actions, including induction of E production and tPA enzyme activity, in a variety of animal models [44, 45, 46, 47]. …”

Section: Discussionmentioning

confidence: 99%

A Naturally Occurring Basically Charged Human Follicle-Stimulating Hormone (FSH) Variant Inhibits FSH-Induced Androgen Aromatization and Tissue-Type Plasminogen Activator Enzyme Activity in vitro

et al. 1998

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It is well known that deglycosylation of gonadotropins by enzymatic or chemical procedures or by deletion of sites for N-linked glycosylation produces antagonistic analogs which are able to interact strongly with the receptor and to inhibit binding of the wild-type hormone. In the present study, we analyzed the antagonistic properties of a naturally occurring basic follicle-stimulating hormone (FSH) charge isoform obtained after high-resolution chromatofocusing of human anterior pituitary glycoprotein extracts. Coincubation of increasing amounts of this isoform with a highly purified human pituitary FSH preparation or with recombinant human FSH at doses equivalent to their corresponding ED₅₀ for estradiol and tissue-type plasminogen activator (tPA) production, inhibited FSH-induced estrogen production and tPA enzyme activity by cultured rat granulosa cells in a dose-dependent manner. These inhibitory effects were apparently exerted at steps following 3′,5′-cyclic adenosine monophosphate (cAMP) formation and did not involve activation of the protein kinase C pathway since: (a) at low doses, this basic FSH isoform moderately increased FSH-induced cAMP production by cultured rat granulosa cells; (b) coincubation of the antagonist isoform with dibutyryl cAMP completely inhibited the effects of this cAMP analog on estrogen and tPA production; (c) the isoform was able to stimulate production of cAMP in a human fetal cell line expressing the recombinant human FSH receptor, and (d) the inhibitory effects of the isoform were not affected by staurosporine, a protein kinase C inhibitor. The effects of this isoform upon dibutyryl cAMP-induced estrogen and tPA production were blocked by the addition of a highly specific antibody directed against human FSH, further demonstrating that the antagonistic effects observed were due to FSH-like molecules. In contrast to the inhibitory effects exhibited by this basic FSH isoform, a more acidic FSH charge variant consistently acted as an agonist of pituitary and recombinant FSH on both estrogen production and induction of tPA enzyme activity. These results indicate that the anterior pituitary gland normally produces FSH isoforms which act as either agonists or antagonists of FSH at the target cell level.

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“…1). In isolated perfused rabbit ovaries, IGF1 stimulated ovarian Ang II production (Yoshimura et al 1996a), and in cattle, IGF1 induced an increase in AGTR2 mRNA and protein (Portela et al 2008). This interaction between Ang II and IGF1 suggests that Ang II is required for antral follicle development and may explain the temporary 'rescue' of the larger subordinate follicle from atresia.…”

Section: Ang II Signaling: Studies In Vivo and In Vitromentioning

confidence: 97%

“…The members of plasminogen activator (PA) family, cathepsin D and chymase, are enzyme candidates to convert Ang I into the octapeptide Ang II (for review see Paul et al (2006)). Yoshimura et al (1996a) used streptokinase, an exogenous PA, to stimulate the intrafollicular Ang II content and follicular growth in the rabbit. The same authors have shown using an in vitro-perfused rabbit ovary model that IGF1 stimulates both follicular growth and PA activity in the follicular fluid.…”

Section: Ovarian Rasmentioning

confidence: 99%

Role of angiotensin in ovarian follicular development and ovulation in mammals: a review of recent advances

Gonçalves¹,

Ferreira²,

Gasperin³

et al. 2012

Reproduction

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Angiotensin (Ang) II is widely known for its role in the control of systemic blood vessels. Moreover, Ang II acts on the vascular control of ovarian function, corpus luteum formation, and luteolysis. Over the past 10 years, our research group has been studying the new concept of the renin-angiotensin system (RAS) as an autocrine/paracrine factor regulating steroidogenesis and promoting different cellular responses in the ovary, beyond vascular function. We have developed and used different in vivo and in vitro experimental models to study the role of RAS in the ovary and a brief overview of our findings is presented here. It is widely accepted that there are marked species differences in RAS function in follicle development. Examples of species-specific functions of the RAS in the ovary include the involvement of Ang II in the regulation of follicle atresia in rats vs the requirement of this peptide for the dominant follicle development and ovulation in rabbits and cattle. More recently, Ang-(1-7), its receptor, and enzymes for its synthesis (ACE2, NEP, and PEP) were identified in bovine follicles, implying that Ang-(1-7) has an ovarian function. Other novel RAS components (e.g. (pro)renin receptor and renin-binding protein) recently identified in the bovine ovary show that ovarian RAS is poorly understood and more complex than previously thought. In the present review, we have highlighted the progress toward understanding the paracrine and autocrine control of ovarian antral follicle development and ovulation by ovarian tissue RAS, focusing on in vivo studies using cattle as a model.

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Interactions between insulin-like growth factor-I (IGF-I) and the renin-angiotensin system in follicular growth and ovulation.

Cited by 27 publications

References 49 publications

Oocyte Maturation in Humans: the Potential Relevance to Reproductive Medicine

Oocyte Maturation in Humans: the Potential Relevance to Reproductive Medicine

A Naturally Occurring Basically Charged Human Follicle-Stimulating Hormone (FSH) Variant Inhibits FSH-Induced Androgen Aromatization and Tissue-Type Plasminogen Activator Enzyme Activity in vitro

Role of angiotensin in ovarian follicular development and ovulation in mammals: a review of recent advances

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