2015
DOI: 10.3389/fimmu.2015.00201
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Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer

Abstract: The glycosaminoglycan hyaluronan (HA), a major component of extracellular matrices, and cell surface receptors of HA have been proposed to have pivotal roles in cell proliferation, migration, and invasion, which are necessary for inflammation and cancer progression. CD44 and receptor for HA-mediated motility (RHAMM) are the two main HA-receptors whose biological functions in human and murine inflammations and tumor cells have been investigated comprehensively. HA was initially considered to be only an inert co… Show more

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Cited by 636 publications
(594 citation statements)
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“…S3; supplemental Table S4 and S5). CD44 antigen is also a transmembrane receptor protein and elevated levels of its soluble form in circulating fluids are known to promote tumor metastasis (30). Complement C4-A (C4A), secreted by macrophages, is part of the innate immune system.…”
Section: Reprogramming Of Distant Organ Functions May Be Associated Wmentioning
confidence: 99%
“…S3; supplemental Table S4 and S5). CD44 antigen is also a transmembrane receptor protein and elevated levels of its soluble form in circulating fluids are known to promote tumor metastasis (30). Complement C4-A (C4A), secreted by macrophages, is part of the innate immune system.…”
Section: Reprogramming Of Distant Organ Functions May Be Associated Wmentioning
confidence: 99%
“…Hyaluronan thus regulates cell proliferation, migration and invasiveness, a matter of utmost relevance during inflammation, wound healing, tissue development or the formation and spreading of tumours [5]. Moreover, hyaluronan is able to control/modulate cell responses by acting as ligand to specific hyaluronan-membrane receptors [6][7][8].…”
mentioning
confidence: 99%
“…Two of these cell surface hyaladherins, RHAMM and CD44, are clinically significant in various cancer models (16,19,22). These hyaladherins have been demonstrated to provide multi-drug resistance, assist with anchorage independent growth, and cell motility of cancer cells (23)(24)(25). Since both RHAMM and CD44 serve a major role in tumor progression, the authors investigated whether these proteins were involved in HA driven rapid growth of bladder cancer cells with AGL loss.…”
Section: Agl and Hyaluronic Acid Receptorsmentioning
confidence: 99%