Interactions between glia, the immune system and pain processes during early development

Barr, Gordon A.; Hunter, Deirtra

doi:10.1002/dev.21229

Cited by 6 publications

(5 citation statements)

References 188 publications

(199 reference statements)

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“…Both the level of stress 8 and the sex of the infant 20 have recently been shown to be factors determining pain-related activity in the brain. During their hospital stay, the severity of illness influences neonatal pain-related behaviour 21 : a diagnosis of jaundice can result in delayed cortical somatosensory processing 22 , and infections can lead to an increase in pain sensitivity 23 , 24 . The number of painful procedures that neonates are exposed to is correlated with their future brain maturation, pain-related behaviour, stress reactivity and cognitive development 25–30 .…”

Section: Background and Summarymentioning

confidence: 99%

EEG, behavioural and physiological recordings following a painful procedure in human neonates

et al. 2018

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We present a dataset of cortical, behavioural, and physiological responses following a single, clinically required noxious stimulus in a neonatal sample. Cortical activity was recorded from 112 neonates (29–47 weeks gestational age at study) using a 20-channel electroencephalogram (EEG), which was time-locked to a heel lance. This data is linked to pain-related behaviour (facial expression), physiology (heart rate, oxygenation) and a composite clinical score (Premature Infant Pain Profile, PIPP). The dataset includes responses to non-noxious sham and auditory controls. The infants’ relevant medical and pain history was collected up to the day of the study and recorded in an extensive database of variables including clinical condition at birth, diagnoses, medications, previous painful procedures, injuries, and selected maternal information. This dataset can be used to investigate the cortical, physiological, and behavioural pain-related processing in human infants and to evaluate the impact of medical conditions and experiences upon the infant response to noxious stimuli. Furthermore, it provides information on the formation of individual pain phenotypes.

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Section: Background and Summarymentioning

confidence: 99%

EEG, behavioural and physiological recordings following a painful procedure in human neonates

et al. 2018

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“…An appropriately powered confirmatory study is warranted to test the hypothesis derived from this exploratory study. While CRP was used in this study as a marker of inflammation, there is value in complementing the current approach in future studies by exploring other factors such as elevated leucocyte count and other inflammatory markers commonly reported in the literature 10 .…”

Section: Resultsmentioning

confidence: 99%

“…How the development of these two systems influences each other is much less clear, even though it is a highly relevant clinical question. Suspected infection is very prevalent in neonates 8 , affecting 13–20% of infants in the postnatal wards 9 , yet the consequences that such early-life inflammation may have on human nociceptive circuitry are not known 10 . Evidence from the preclinical literature suggests that neonatal inflammation might have very serious consequences 11 .…”

Section: Introductionmentioning

confidence: 99%

Early life inflammation is associated with spinal cord excitability and nociceptive sensitivity in human infants

et al. 2022

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Immune function and sensitivity to pain are closely related, but the association between early life inflammation and sensory nervous system development is poorly understood—especially in humans. Here, in term-born infants, we measure brain activity and reflex withdrawal activity (using EEG and EMG) and behavioural and physiological activity (using the PIPP-R score) to assess the impact of suspected early-onset neonatal infection on tactile- and noxious-evoked responses. We present evidence that neonatal inflammation (assessed by measuring C-reactive protein levels) is associated with increased spinal cord excitability and evoked brain activity following both tactile and noxious stimulation. There are early indications that this hyperalgesia could be maintained post-inflammation, supporting pre-clinical reports of early-life immune dysfunction influencing pain sensitivity in adults.

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“…Pain and stress in newborn rat pups may alter characteristics of the nociceptive system and HPA axis development. In newborn rats, the nociceptive system, in which 5-HT1A receptors are important for the structural and functional development of neural circuits, shows high sensitivity to painful stimuli (Barr, 1998 ; Fitzgerald, 2005 ; Barr and Hunter, 2014 ). This is due to several major factors such as immaturity of C-fibers and the dominant role of low-threshold A-fibers in nociception (Beggs et al, 2002 ), transient excitatory gamma-aminobutyric acid (GABA) function at the spinal and supraspinal levels (Hatfield, 2014 ), and immaturity of the descending monoaminergic system (Butkevich I. P. et al, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

Long-Term Effects of Chronic Buspirone during Adolescence Reduce the Adverse Influences of Neonatal Inflammatory Pain and Stress on Adaptive Behavior in Adult Male Rats

Butkevich

Mikhailenko

Vershinina

et al. 2017

Front. Behav. Neurosci.

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Neonatal pain and stress induce long-term changes in pain sensitivity and behavior. Previously we found alterations in pain sensitivity in adolescent rats exposed to early-life adverse events. We tested whether these alterations have long-lasting effects and if those effects can be improved by the 5-hydroxytryptamine 1A (5-HT1A) receptor agonist buspirone injected chronically during the adolescent period. This study investigates: (1) effects of inflammatory pain (the injection of formalin into the pad of a hind paw) or stress (short maternal deprivation-isolation, MI), or their combination in 1–2-day-old rats on the adult basal pain, formalin-induced pain, anxiety and depression; (2) effects of adolescent buspirone in adult rats that experienced similar early-life insults. Changes in nociceptive thresholds were evaluated using the hot plate (HP) and formalin tests; levels of anxiety and depression were assessed with the elevated plus maze and forced swim tests respectively. Both neonatal painful and stressful treatments induced long-term alterations in the forced swim test. Other changes in adult behavioral responses were dependent on the type of neonatal treatment. There was a notable lack of long-term effects of the combination of early inflammatory pain and stress of MI on the pain responses, anxiety levels or on the effects of adolescent buspirone. This study provides the first evidence that chronic injection of buspirone in adolescent rats alters antinociceptive and anxiolytic effects limited to adult rats that showed behavioral alterations induced by early-life adverse treatments. These data highlight the role of 5-HT1A receptors in long-term effects of neonatal inflammatory pain and stress of short MI on adaptive behavior and possibility of correction of the pain and psychoemotional behavior that were altered by adverse pain/stress intervention using buspirone during critical adolescent period.

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Interactions between glia, the immune system and pain processes during early development

Cited by 6 publications

References 188 publications

EEG, behavioural and physiological recordings following a painful procedure in human neonates

EEG, behavioural and physiological recordings following a painful procedure in human neonates

Early life inflammation is associated with spinal cord excitability and nociceptive sensitivity in human infants

Long-Term Effects of Chronic Buspirone during Adolescence Reduce the Adverse Influences of Neonatal Inflammatory Pain and Stress on Adaptive Behavior in Adult Male Rats

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