EEG, behavioural and physiological recordings following a painful procedure in human neonates

Abstract

We present a dataset of cortical, behavioural, and physiological responses following a single, clinically required noxious stimulus in a neonatal sample. Cortical activity was recorded from 112 neonates (29–47 weeks gestational age at study) using a 20-channel electroencephalogram (EEG), which was time-locked to a heel lance. This data is linked to pain-related behaviour (facial expression), physiology (heart rate, oxygenation) and a composite clinical score (Premature Infant Pain Profile, PIPP). The dataset includes responses to non-noxious sham and auditory controls. The infants’ relevant medical and pain history was collected up to the day of the study and recorded in an extensive database of variables including clinical condition at birth, diagnoses, medications, previous painful procedures, injuries, and selected maternal information. This dataset can be used to investigate the cortical, physiological, and behavioural pain-related processing in human infants and to evaluate the impact of medical conditions and experiences upon the infant response to noxious stimuli. Furthermore, it provides information on the formation of individual pain phenotypes.

The impact of parental contact upon cortical noxious‐related activity in human neonates

“…The EEG response for all groups comprised a sequence of three event‐related potentials (ERPs) from 89 to 755 ms at comparable latencies (Figure 2) with a concentric distribution and a negative or positive peak at the vertex (Cz and/or CPz), two of which did not significantly differ across groups (Figure 3). The last of these events (497–755 ms) is the previously described noxious ERP (nERP) (Fabrizi et al., 2011; Jones et al., 2018; Verriotis, Chang, Fitzgerald, & Fabrizi, 2016), and was modulated by parental contact, with skin‐to‐skin having the lowest global field power (GFP) (5.89 µV at 601 ms), followed by cot, individualized‐care (8.24 µV at 684 ms) then held with clothing (12.46 µV at 563 ms). Skin‐to‐skin had a significantly dampened nERP compared to being held with clothes ( p = 0.016), however, the difference between skin‐to‐skin and cot, individualized‐care did not reach significance ( p > 0.050).…”

“…The brain response to a clinically required heel lance comprised a sequence of three event-related potentials (ERPs) independently of presence and style of parental contact. Based on their concentric distribution, polarity and latency, it is clear that these events are the somatosensory and noxious events observed in previous work at electrode Cz/CPz (N2, N3, P3 Fabrizi et al, 2011;Jones et al, 2018;Verriotis et al, 2016). The last of these cortical events is considered noxious-related (nERP) as it is evoked only when the lancet blade cuts the skin, but not following a sham control procedure (Fabrizi et al, 2011).…”

“…Mothers were informed that they could hold their baby dressed, in skin‐to‐skin care, or have their baby in their cot or incubator for the study, resulting in a naturalistic sample indicative of a realistic hospital population and protocol. For further description of the study see Jones et al (Jones et al., 2018).…”

“…Data used in this project can be accessed from the UK Data Service repository. Please see the related Data Descriptor for more details (Jones et al, 2018). 3 | RESULTS…”

A database for using machine learning and data mining techniques for coronary artery disease diagnosis

“…Although there are some datasets for various diseases 27–40 , there are no comprehensive benchmarks publicly available to summarize the research and conclusions on CAD diagnosis. As a result, the studies in this field are not well organized.…”