Interactions between functional serotonergic polymorphisms and demographic factors influence personality traits in healthy Spanish Caucasians

Sáiz, Pilar A.; García-Portilla, María Paz; Herrero, Rocío; Arango, Celso; Corcoran, Paul; Morales, Blanca; Bascarán, María Teresa Bobes; Álvarez, Victoria; Coto, Eliécer; Paredes, Begoña; Fernández, Juan M.; Bobes, Julio

doi:10.1097/ypg.0b013e32833a20b9

Cited by 20 publications

(19 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lopez de Lara et al (2006) found no relation between variation in STin2 genotype and adults’ impulsive–aggressive or cooperative behavior. However, Davidge et al (2004) found that the STin2 10 variant was more common in highly aggressive children, and Saiz et al (2010) found that STin2 interacted with sex to predict cooperation in adult Spaniards; cooperation behavior was high in women only if they carried the 10 variant.…”

mentioning

confidence: 99%

Interactions between serotonin transporter gene haplotypes and quality of mothers' parenting predict the development of children's noncompliance.

Sulik¹,

Eisenberg²,

Lemery‐Chalfant³

et al. 2012

Developmental Psychology

View full text Add to dashboard Cite

The LPR and STin2 polymorphisms of the serotonin transporter gene (SLC6A4) were combined into haplotypes that, together with quality of maternal parenting, were used to predict initial levels and linear change in children’s (N = 138) noncompliance and aggression from age 18 –54 months. Quality of mothers’ parenting behavior was observed when children were 18 months old, and nonparental caregivers’ reports of noncompliance and aggression were collected annually from 18 to 54 months of age. Quality of early parenting was negatively related to the slope of noncompliance only for children with the LPR-S/STin2-10 haplotype and to 18-month noncompliance only for children with haplotypes that did not include LPR-S. The findings support the notion that SLC6A4 haplotypes index differential susceptibility to variability in parenting quality, with certain haplotypes showing greater reactivity to both supportive and unsupportive environments. These different genetic backgrounds likely reflect an evolutionary response to variation in the parenting environment.

show abstract

mentioning

confidence: 99%

Interactions between serotonin transporter gene haplotypes and quality of mothers' parenting predict the development of children's noncompliance.

Sulik¹,

Eisenberg²,

Lemery‐Chalfant³

et al. 2012

Developmental Psychology

View full text Add to dashboard Cite

show abstract

“…No significant differences in allele frequencies were observed between the two groups for other SLC6A4 and AVPR1A polymorphisms. Previous studies have reported possible involvement of STin2 in personality traits and reward behavior (Kazantseva et al, 2008; Zhong et al, 2009; Saiz et al, 2010). SLC6A4 polymorphisms (together with AVPR1A ) have also been linked to participation in creative dance (Bachner-Melman et al, 2005).…”

Section: Summary Of the Review Findingsmentioning

confidence: 96%

The genetic basis of music ability

Tan¹,

McPherson²,

Peretz³

et al. 2014

Front. Psychol.

View full text Add to dashboard Cite

Music is an integral part of the cultural heritage of all known human societies, with the capacity for music perception and production present in most people. Researchers generally agree that both genetic and environmental factors contribute to the broader realization of music ability, with the degree of music aptitude varying, not only from individual to individual, but across various components of music ability within the same individual. While environmental factors influencing music development and expertise have been well investigated in the psychological and music literature, the interrogation of possible genetic influences has not progressed at the same rate. Recent advances in genetic research offer fertile ground for exploring the genetic basis of music ability. This paper begins with a brief overview of behavioral and molecular genetic approaches commonly used in human genetic analyses, and then critically reviews the key findings of genetic investigations of the components of music ability. Some promising and converging findings have emerged, with several loci on chromosome 4 implicated in singing and music perception, and certain loci on chromosome 8q implicated in absolute pitch and music perception. The gene AVPR1A on chromosome 12q has also been implicated in music perception, music memory, and music listening, whereas SLC6A4 on chromosome 17q has been associated with music memory and choir participation. Replication of these results in alternate populations and with larger samples is warranted to confirm the findings. Through increased research efforts, a clearer picture of the genetic mechanisms underpinning music ability will hopefully emerge.

show abstract

“…20 Additionally, rs25531 has been shown to have an effect on amygdala activity in response to angry, happy, or sad emotions. 38 Compared with the other 2 loci, there is less literature concerning STin2, but this polymorphism has been associated with harm avoidance, 39 suicidality, 40 psychosis, 41 and migraine headaches. 42 Thus, despite evidence that this polymorphism is likely functional, 12 to our knowledge, there is no evidence associating this variant with risk for PTSD.…”

Section: Commentmentioning

confidence: 99%

Acute and Posttraumatic Stress Symptoms in a Prospective Gene × Environment Study of a University Campus Shooting

Mercer

Orcutt²,

Quinn³

et al. 2012

Arch Gen Psychiatry

View full text Add to dashboard Cite

Context The serotonin transporter (SLC6A4) has been associated with several stress-related syndromes including posttraumatic stress disorder (PTSD). The ability to detect meaningful associations is largely dependent on reliable measures of preexisting trauma. Objective To study the association of genetic variants within SLC6A4 with acute and posttraumatic stress symptoms in a civilian cohort with known levels of preexisting trauma and PTSD symptoms collected prior to a shared index traumatic event. Design Ongoing longitudinal study. Setting On February 14, 2008, a lone gunman shot multiple people on the campus of Northern Illinois University in DeKalb, Illinois, killing 5 and wounding 21. As part of an ongoing longitudinal study on that campus, a cohort of female undergraduate students, interviewed prior to the shooting, completed follow-up trauma-related measures including PTSD symptom severity (follow-up survey was launched 17 days postshooting; n=691). To obtain DNA, salivary samples were collected from a subset of the original study population based on willingness to participate (n=276). Participants Two hundred four undergraduate women. Main Outcome Measures SLC6A4 polymorphisms STin2, 5-HTTLPR, and rs25531 were genotyped in 235 individuals. Results We found that although the STin2 variant and 5-HTTLPR alone did not associate with increased PTSD symptoms, rs25531 and the 5-HTTLPRmultimarker genotype (combined 5-HTTLPR and rs25531) were associated with significantly increased acute stress disorder symptoms at 2 to 4 weeks postshooting (n = 161; P<.05). This association remained significant when controlling for race and for level of shooting exposure (n = 123; P<.007). The association was most robust with the 5-HTTLPR multimarker genotype and avoidance symptoms (P=.003). Conclusion These data suggest that differential function of the serotonin transporter may mediate differential response to a severe trauma. When examined in a relatively homogenous sample with shared trauma and known prior levels of child and adult trauma, the 5-HTTLPR multimarker genotype may serve as a useful predictor of risk for PTSD-related symptoms in the weeks and months following the trauma.

show abstract

Interactions between functional serotonergic polymorphisms and demographic factors influence personality traits in healthy Spanish Caucasians

Abstract: Our findings suggest a strong genetic component in personality traits manifested primarily through interaction effects that occur between genetic factors alone and between genetic and demographic factors.

Cited by 20 publications

References 53 publications

Interactions between serotonin transporter gene haplotypes and quality of mothers' parenting predict the development of children's noncompliance.

Interactions between serotonin transporter gene haplotypes and quality of mothers' parenting predict the development of children's noncompliance.

The genetic basis of music ability

Acute and Posttraumatic Stress Symptoms in a Prospective Gene × Environment Study of a University Campus Shooting

Contact Info

Product

Resources

About