Interactions between drugs and four common medicinal herbs

McFadden, Roger; Peterson, Nicola

doi:10.7748/ns2011.01.25.19.65.c8273

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…The mice that drank echinacea alone did not have increased apoptosis compared with the controls. 12,48,74,[77][78][79] Although several authors caution against combining garlic and warfarin, 48,67,74,[80][81][82] two very small studies show that it may possibly be safe. They found 967 suspected reactions of which 8.1% involved echinacea and 7.3% involved echinacea plus ginseng.…”

Section: St John's Wortmentioning

confidence: 99%

Anesthesia and Herbal Supplements

Danloff¹

2012

ASA Refresher Courses in Anesthesiology

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Section: St John's Wortmentioning

confidence: 99%

Anesthesia and Herbal Supplements

Danloff¹

2012

ASA Refresher Courses in Anesthesiology

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“…The interactive effect includes additive, antagonism and synergistic (McFadden and Peterson, 2011). The additive effect means that two drugs, with similar therapeutic action, when used together, can summate and result in unexpected effects.…”

Section: Introductionmentioning

confidence: 99%

Free radical scavenging activity of Chinese traditional four substances decoction (FSD) extracts

Wang¹

2012

Afr. J. Pharm. Pharmacol.

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This article examined the interactive effect among herbs extracts in combined use, compared with the effect of individual herbal extracts on 1,1-diphenyl picryl hydrazyl (DPPH). The Chinese traditional prescription, four substances decoction (FSD) consisted of 25 g of Angelica sinensis (Umbelliferae, AS), 6 g of Ligusticum chuanxiong Hort. (Umbelliferae, LCH), 10 g of Paeonia loactiflora Pall. (Paeoniaceae, PCP), and 15 g of Radix rehmanniae preparata (Scrophulariaceae, RRP). Each herb was quantitatively mixed according to the FSD prescription ratio. The interaction between the herbal extract in two-two combination way were estimated using a spectrophotometer. The results showed the strongest synergistic effect in LCH and PLP system, with IC 50 0.25 mg/ml, and the additive effect was obvious in the AS and LCH combined system. The other combined system showed additive effect or sub-additive effect. This implied that the combined system effect have a close relationship with the single component activity.

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Common phyto-remedies used against cardiovascular diseases and their potential to induce adverse events in cardiovascular patients

Suroowan

Mahomoodally

2015

Clin Phytosci

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Cardiovascular diseases (CVDs) remain the leading cause of death globally. In addition to conventional medications, a plethora of herbal products continue to offer therapeutic alternatives to patients to assuage suffering. Nonetheless, concomitant administration of herbs and conventional medicine are not always safe which could mimic, oppose or magnify the effect of the latter leading to serious herb-drug interactions, most of which escape pharmacovigilance. The paucity of relevant information to clinicians in relation to herb-drug interactions, the inadequacy of evidence-based knowledge coupled with the lack of mechanistic facts poses a momentous threat to meet desired therapeutic outcomes in CVD patients. In this endeavor, key scientific databases have been explored to review common herbal products that might interfere clinically with conventional drugs used for CVDs and related complications. Ten common medicinal plants have been included and representative case reports whereby herbal products are thought to be inducers of adverse events are also discussed. It is anticipated that the present review will be a pinnacle of evidence and hence serve as an up-to-date fundamental repertoire of recent scientific findings to promote better understanding of adverse herb-drug events amongst clinicians and enhance rapport between clinicians and patients for subsequent counseling. Indeed, acknowledging the risks attributed to herb-drug interactions is fundamental in the management of CVDs and related implications which should not be underestimated or considered as trivial by both health-care professionals and herbal consumers.

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Interactions between drugs and four common medicinal herbs

Cited by 5 publications

References 20 publications

Anesthesia and Herbal Supplements

Anesthesia and Herbal Supplements

Free radical scavenging activity of Chinese traditional four substances decoction (FSD) extracts

Common phyto-remedies used against cardiovascular diseases and their potential to induce adverse events in cardiovascular patients

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