Interactions between cardiovascular and pain regulatory systems

Randich, Alan; Maixner, William

doi:10.1016/0149-7634(84)90057-5

Cited by 387 publications

(111 citation statements)

References 197 publications

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“…Their afferents project to similar CNS structures (Eckberg & Sleight, 1992;Henderson et al, 2004;Kimmerly et al, 2005), and, although psychophysiologically less explored, they seem to exert inhibitory effects on non-cardiovascular parameters comparable to those of their arterial counterparts. That is, dampening effects of cardiopulmonary baroreceptor activity were found for startle responses (Richter, Schulz, Port, Blumenthal, & Schächinger, 2009), pain perception (D'Antono, Ditto, Sita, & Miller, 2000Randich & Maixner, 1984;Sheps et al, 1992;Vaitl, Gruppe, Stark, & Pössel, 1996), and spontaneous cortical activity (Vaitl & Gruppe, 1990). Nevertheless, effects of arterial and cardiopulmonary baroreceptor activation must not be lumped together as there are several studies that indicate differential effects.…”

Section: Discussionmentioning

confidence: 88%

Baroreceptor activity impacts upon controlled but not automatic distractor processing

Pramme

Schächinger

Frings

2015

Biological Psychology

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Section: Discussionmentioning

confidence: 88%

Baroreceptor activity impacts upon controlled but not automatic distractor processing

Pramme

Schächinger

Frings

2015

Biological Psychology

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“…The outcomes of multiple studies have linked baroreceptor function to pain sensitivity and psychological function. 9, 56, 57, 59, 76–79 There is also evidence that chronic pain conditions, including TMD, are associated with a baroreceptor mediated dysregulation of pain perception. For example, TMD cases fail to show the typical relationship between resting mean arterial BP, which is the primary physiological stimulus of the carotid sinus baroceptor system, and pain perception.…”

Section: Discussionmentioning

confidence: 99%

“…One possible protective factor is the increase prevalence of hypertension in the African American population, which may confer protective effects on the development of chronic pain conditions. 9, 25, 29, 30, 55, 56, 76 …”

Section: Discussionmentioning

confidence: 99%

Potential Autonomic Risk Factors for Chronic TMD: Descriptive Data and Empirically Identified Domains from the OPPERA Case-Control Study

Maixner

Greenspan

Dubner

et al. 2011

The Journal of Pain

Self Cite

113

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Several case-control studies have been conducted that examine the association between autonomic variables and persistent pain conditions; however, there is a surprising dearth of published studies in this area that have focused on temporomandibular disorders (TMD). The current study presents autonomic findings from the baseline case-control study of the OPPERA (Orofacial Pain: Prospective Evaluation and Risk Assessment) cooperative agreement. Measures of arterial blood pressure, heart rate, heart rate variability, and indirect measures of baroreflex sensitivity were assessed at rest and in response to a physical (orthostatic) and psychological (Stroop) stressors in 1633 TMD-free controls and 185 TMD cases. In bivariate and demographically adjusted analyses, greater odds of TMD case status were associated with elevated heart rates, reduced heart rate variability, and reduced surrogate measures of baroreflex sensitivity across all experimental procedures. Principal component analysis was undertaken to identify latent constructs revealing five components. These findings provide evidence of associations between autonomic factors and TMD. Future prospective analyses in the OPPERA cohort will determine if the presence of these autonomic factors predicts increased risk for developing new onset TMD.

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“…These effects have been reported since 1932tt; more recently, we (19) and others (20,22,24) have refined the experimental methods for animals to eliminate confounding artifacts and confirm that the inhibition is an authentic product of baroreceptor stimulation. The present results extend a similar level of experimental verification to humans.…”

Section: Discussionmentioning

confidence: 99%

Central effects of baroreceptor activation in humans: attenuation of skeletal reflexes and pain perception.

Dworkin

Elbert

Rau

et al. 1994

Proc. Natl. Acad. Sci. U.S.A.

223

140

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Activating (4), induce synchronization of the electroencephalogram (5), increase cortical positivity (6), blunt pain sensations (7), reduce anxiety (8, 9), and induce sleep (10) or even clinically significant syncope (11). Arousing emotional and pain stimuli elevate blood pressure (12)(13)(14)(15)(16)(17)(18), and the central nervous system (CNS) inhibitory effects ofbarostimulation most simply can be seen to provide supplementary negative feedback, which, along with cardioinhibition and vasodilatation, helps to restore excessively elevated blood pressure to a safer level. Dworkin et al. (19) reported that rats escape from and avoid a mildly aversive trigeminal nucleus stimulus to a lesser degree when their blood pressure is pharmacologically elevated and that the effect can be abolished by denervation of the baroreceptors. They also showed that the impaired avoidance behavior persists into extinction, suggesting that, in addition to pain perception, anxiety is affected. In an extensive series of experiments using more conventional pain stimuli, Randich and Maixner (20) Abbreviations: CNS, central nervous system; CSPP, carotid sinus pulse pressure; PRES, phase-related external suction; EMG, electromyographic or electromyogram; G-G, Greenhouse-Geisser. ITo whom reprint requests should be addressed. 6329The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.

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Interactions between cardiovascular and pain regulatory systems

Cited by 387 publications

References 197 publications

Baroreceptor activity impacts upon controlled but not automatic distractor processing

Baroreceptor activity impacts upon controlled but not automatic distractor processing

Potential Autonomic Risk Factors for Chronic TMD: Descriptive Data and Empirically Identified Domains from the OPPERA Case-Control Study

Central effects of baroreceptor activation in humans: attenuation of skeletal reflexes and pain perception.

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