Interactions Between Aspirin and Other Compounds in Analgesic Medicines on Gastric Mucosal Damage in Rats

Jager, L. P.; Seegers, A. J. M.; Noordwijk, J. van

doi:10.1007/978-1-4684-3896-3_30

Cited by 2 publications

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“…The results with subcutaneously administered paracetamol and orally administered indomethacin and vice versa indicate that, as in the case of aspirin [22], the protective activity of paracetamol is not due to a physicochemical interaction of the two compounds in the gastric lumen. Paracetamol has no effect on gastric secretion [8], hence its protective action is probably due to a pharmacodynamic effect on the mucosal cells which increases their resistance against noxious stimuli such as gastric acid and aspirin.…”

Section: Discussionmentioning

confidence: 85%

The influence of paracetamol on the erosive activity of indomethacin in the rat stomach

Kolfschoten

Zandberg²,

Jager³

et al. 1982

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Indomethacin induced erosions in the glandular part of the rat stomach in a dose-dependent manner. Gastric erosions became apparent about 15 min after administration of indomethacin and the damage was maximal at about 4 h. The erosive activity of indomethacin administered subcutaneously was similar to that after oral administration, confirming the data of other authors. The erosive activity of subcutaneously applied aspirin, however, was far less than that of oral administered aspirin and it was not dose dependent. In a dose-dependent manner, paracetamol reduced the incidence of gastric erosions induced with indomethacin; this effect was independent of the route of administration of either drug. Paracetamol was also effective when given 0.5 or 1 h before indomethacin. Orally administered paracetamol also reduced the incidence of gastric erosions induced with aspirin but after subcutaneous administration, paracetamol had no protective effect. The differences between the erosive activities of indomethacin and aspirin are discussed with emphasis on the differentiating influence of paracetamol on the incidence of gastric erosions. Direct contact with the mucosa is apparently more important for the erosive activity of aspirin than for that of indomethacin. Possible mechanisms by which paracetamol exerts its protective activity are proposed.

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Section: Discussionmentioning

confidence: 85%