Interactions and clinical implications of serological and respiratory variables 3 months after acute COVID-19

Freund, Ophir; Breslavsky, Anna; Fried, Sabrina; Givoli-Vilensky, Rotem; Cohen-Rubin, Shira; Zacks, Nadav; Kleinhendler, Eyal; Unterman, Avraham; Frydman, Shir; Wand, Ori; Bilenko, Natalya; Bar-Shai, Amir

doi:10.1007/s10238-023-01139-5

Cited by 6 publications

(7 citation statements)

References 30 publications

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“…Although non-hospitalized patients who visited our CORE clinics were more likely to exhibit symptoms given the nature of their visit, these data suggested that long COVID is not limited to severely ill COVID-19 patients. A recent prospective study demonstrates similar findings, in which patients with high respiratory symptomatic burden 3-months post-COVID were associated with high disease severity 40 . Previous studies have reported individuals with mild symptoms from SARS-CoV-2 infection (i.e., not requiring hospitalization) or asymptomatic infection may also be susceptible to general and neurological PASC 41 – 43 .…”

Section: Discussionsupporting

confidence: 56%

Patients with unmet social needs are at higher risks of developing severe long COVID-19 symptoms and neuropsychiatric sequela

Eligulashvili,

Darrell,

Gordon

et al. 2024

Sci Rep

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This study investigated long COVID of patients in the Montefiore Health System COVID-19 (CORE) Clinics in the Bronx with an emphasis on identifying health related social needs (HRSNs). We analyzed a cohort of 643 CORE patients (6/26/2020–2/24/2023) and 52,089 non-CORE COVID-19 patients. Outcomes included symptoms, physical, emotional, and cognitive function test scores obtained at least three months post-infection. Socioeconomic variables included median incomes, insurance status, and HRSNs. The CORE cohort was older age (53.38 ± 14.50 vs. 45.91 ± 23.79 years old, p < 0.001), more female (72.47% vs. 56.86%, p < 0.001), had higher prevalence of hypertension (45.88% vs. 23.28%, p < 0.001), diabetes (22.86% vs. 13.83%, p < 0.001), COPD (7.15% vs. 2.28%, p < 0.001), asthma (25.51% vs. 12.66%, p < 0.001), lower incomes (53.81% vs. 43.67%, 1st quintile, p < 0.001), and more unmet social needs (29.81% vs. 18.49%, p < 0.001) compared to non-CORE COVID-19 survivors. CORE patients reported a wide range of severe long-COVID symptoms. CORE patients with unmet HRSNs experienced more severe symptoms, worse ESAS-r scores (tiredness, wellbeing, shortness of breath, and pain), PHQ-9 scores (12.5 (6, 17.75) vs. 7 (2, 12), p < 0.001), and GAD-7 scores (8.5 (3, 15) vs. 4 (0, 9), p < 0.001) compared to CORE patients without. Patients with unmet HRSNs experienced worse long-COVID outcomes compared to those without.

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Section: Discussionsupporting

confidence: 56%

Patients with unmet social needs are at higher risks of developing severe long COVID-19 symptoms and neuropsychiatric sequela

Eligulashvili,

Darrell,

Gordon

et al. 2024

Sci Rep

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“…According to our available pulmonary function test results, FEV1 levels were lower after moderate and severe COVID-19 infections, while changes in the Tiffeneau-index did not show a correlation with the severity of previous COVID-19 infections, as a previous study has shown [ 37 ].…”

Section: Discussionmentioning

confidence: 57%

“…A medium score (9-24) was marked by 63 patients (59%) with an average of 16.7 points. A high score (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40) was marked by 18 patients (17%) with an average of 28.7 points. There was no significant correlation between lung function values and CAT scores.…”

Section: Cat Scorementioning

confidence: 99%

Co-Morbidity Clusters in Post-COVID-19 Syndrome

Sárközi,

Tornyi,

Békési

et al. 2024

JCM

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Background: Post-COVID-19 syndrome, characterized by persistent symptoms emerging more than 12 weeks after acute infection, displays diverse manifestations. This study aimed to analyze co-existing organ dysfunctions in post-COVID-19 patients and explore their potential association with the acute COVID-19 episode and functional impairment. Methods: Data from 238 patients attending post-COVID-19 outpatient care between 1 March 2021 and 1 March 2022, after previous hospitalization for acute COVID-19, were retrospectively analyzed with 80 having comprehensive mapping of organ involvement. Results: The average time between acute episode and post-COVID-19 care was 149 days. Spirometry indicated significant abnormalities in lung function. Predominant symptoms included respiratory (75%), fatigue (73%), neurological (62.5%), and ear-nose-throat issues (51.25%). Multiorgan dysfunctions were observed in 87.5% of patients, contributing to an 18.33% reduction in health quality compared to pre-acute COVID-19 levels. Subgroup analysis identified four distinct post-COVID-19 syndrome subgroups, highlighting the coexistence of respiratory and neurological disorders as potential indicators and drivers of further organ involvement. Our results reveal that most patients with post-COVID-19 syndrome suffer from multiorgan disorders. Conclusions: The presence of coexisting respiratory and neurological symptoms suggests the involvement of other organ systems as well. The complexity of multiorgan involvement requires further studies to provide insights into the different symptom clusters and identify potential targets for personalized preventive and therapeutic interventions to improve patient outcome.

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“…Emerging research is beginning to explore risk factors associated with the development of PASC and the treatment of PASC in adults. Some of these include female sex, the severity of acute COVID-19 infection including the need for invasive or noninvasive mechanical ventilation, the severity of initial respiratory disease as assessed with CAT scans, and the length of hospitalization for COVID-19 infection [5,6]. Risk factors such as the patient's diet, alcohol use, smoking behaviors, amount of exercise prior to acute COVID-19 infection, and prior sleep patterns may also contribute to the development of PASC [7].…”

Section: Introductionmentioning

confidence: 99%

Post-Acute Sequelae of COVID-19 (PASC) in Pediatrics: Factors That Impact Symptom Severity and Referral to Treatment

Soprano,

Ngo,

Konys

et al. 2023

Children

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The post-acute sequelae of COVID-19 (PASC) is a complex condition. While there are emerging studies on its effects in adults, there is scarce research regarding the long-term effects of COVID-19 infection among youth. Several researchers have likened long-haul COVID-19 to chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and postural orthostatic tachycardia syndrome (POTS). In adults, the prognosis for these diagnoses is less promising than that in youth; however, there is currently very little information available on the presentation of youth with PASC. A better understanding of the specific symptom presentation for youth diagnosed with PASC is necessary. Retrospective chart reviews were conducted collecting demographic data, COVID-19 symptoms and disease progression, and vaccination status. Additional data on referrals to a PASC treatment program and appointments attended were collected. Overall, data suggested that youth present with less severe PASC symptoms than adults, and the role of vaccination is unclear. These youth are often not referred to treatment programs. More exploration is necessary to continue to build an understanding of how best to aid youth diagnosed with PASC.

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Interactions and clinical implications of serological and respiratory variables 3 months after acute COVID-19

Cited by 6 publications

References 30 publications

Patients with unmet social needs are at higher risks of developing severe long COVID-19 symptoms and neuropsychiatric sequela

Patients with unmet social needs are at higher risks of developing severe long COVID-19 symptoms and neuropsychiatric sequela

Co-Morbidity Clusters in Post-COVID-19 Syndrome

Post-Acute Sequelae of COVID-19 (PASC) in Pediatrics: Factors That Impact Symptom Severity and Referral to Treatment

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