Interactions among variants in P53 apoptotic pathway genes are associated with neurologic deterioration and functional outcome after acute ischemic stroke

Yi, Xingyang; Zhou, Qiang; Sui, Guo; Ren, Gaoping; Tan, Lu; Li, Jie; Lin, Jing; Bao, Shaozhi

doi:10.1002/brb3.1492

Cited by 9 publications

(5 citation statements)

References 44 publications

(88 reference statements)

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“…Fourth, some studies showed that the standard-reaching rate for hypertension, diabetes mellitus, and dyslipidemia (embodied in blood pressure, glucose, and lipids) was very low, and was associated with outcomes ( 10 , 11 ). However, some studies thought that blood pressure, blood glucose, and lipids, as the intermediate markers during medication treatment, were not associated with susceptibility to stroke and outcomes ( 33 , 34 ). In this study, although we investigated the persistence of antihypertensives, hypoglycemics, lipid-lowering medications, and antithrombotics in the high-risk stroke population, the relevant data such as blood pressure, glucose, and lipids at 4.7 years after a face-to-face survey were not collected.…”

Section: Discussionmentioning

confidence: 99%

Persistence of drug therapy is associated with ischemic stroke and other vascular events in high-risk stroke population

Chen²,

Yu³

et al. 2022

Front. Neurol.

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The high-risk stroke populations are significantly associated with an increased risk of stroke or other vascular events. Although proven primary and secondary stroke prevention medications are available, persistent use is required to be effective. However, the persistence of drug therapy and its association with outcomes in the high-risk stroke population have received limited study in China. Hence, according to the China National Stroke Screening Survey (CNSSS) program in 2015, we performed this multicenter population-based cross-sectional survey and prospective cohort study in Sichuan of southwestern China. The residents aged ≥ 40 years volunteered to participate in a face-to-face survey in 8 communities. Subjects with at least three of eight stroke-related risk factors or a history of stroke were defined as high-risk stroke population. The interviewers recorded individuals' medications at a face-to-face survey, and all the high-risk stroke population was followed up for 4.7 years. The persistence of antihypertensives, hypoglycemics, lipid-lowering medications, and antithrombotics for stroke was evaluated. The primary outcome was new stroke. Secondary outcomes included new composite vascular events of stroke, myocardial infarction, and death during follow-up periods. Among 16,892 participants, 2,893 (17.1%) participants were high-risk stroke population and 2,698 (93.3%) participants completed to follow-up. The 4.7-year persistence of therapy rate of antihypertensives, hypoglycemics, lipid-lowering medications, and antithrombotics was 38.0%, 39.9%, 43.9%, and 59.8%, respectively. The total persistence of therapy rate for antihypertensives, hypoglycemics, lipid-lowering medications, and antithrombotics was 47.6% (136/286) in patients with hypertension, diabetes, dyslipidemia, and stroke at the same time. During the 4.7-year follow-up, there were 118 (4.4%) new ischemic stroke, 24 (0.9%) hemorrhagic stroke, 53 (2.0%) myocardial infarctions, and 33 (1.2%) deaths. After adjusting for the covariates, 4.7-year persistence of antihypertensives, hypoglycemics, lipid-lowering therapy, antithrombotics, and total persistence was independently associated with less new ischemic stroke and less new composite vascular events. Thus, more effective public education and efforts to understand and enhance the persistence of drug therapy are crucial to improve population health and decrease stroke and other vascular events for the high-risk stroke population.

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Section: Discussionmentioning

confidence: 99%

Persistence of drug therapy is associated with ischemic stroke and other vascular events in high-risk stroke population

Chen²,

Yu³

et al. 2022

Front. Neurol.

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“…The dataset contains the raw data (supplementary Table), frequencies of alleles and genotypes ( Table 1 ) for three SNPs of two MMP genes (rs1799750 MMP1 , rs3918242 and rs17576 MMP9 ) in Russian patients diagnosed with POAG, EH, and PU. These polymorphisms were previously reported for their association with POAG, EH, and PU ( Table 2 ) [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] . The studied SNPs manifest the regulatory potential ( Table 3 ), which is evidenced by several eQTLs ( Table 4 ) and splicing QTLs ( Table 5 ).…”

Section: Data Descriptionmentioning

confidence: 85%

Dataset of allele and genotype frequencies of the three functionally significant polymorphisms of the MMP genes in Russian patients with primary open-angle glaucoma, essential hypertension and peptic ulcer

et al. 2020

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Data on the allele and genotype frequencies of the three functionally significant single nucleotide polymorphisms (SNPs) of the matrix metalloproteinases ( MMP ) genes (rs1799750 MMP1 , rs3918242 and rs17576 MMP9 ) in Russian patients with primary open-angle glaucoma (POAG), essential hypertension (EH) and peptic ulcer (PU) are presented. Association studies identified these SNPs as possible significant markers associated with many multifactorial disorders, including POAG, EH, and PU. The frequencies of alleles and genotypes of the three SNPs in Russian patients with POAG, EH, and PU were presented separately for the entire study sample, females, and males, respectively. The data can be used as a reference for the Russian population.

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“…p53-mediated neuronal apoptosis plays vital role on stroke pathophysiology and ischemic penumbra injury.Until now,two studies has investigate the p53 apoptotic pathway related gene (P53, P21, MDM-2, and MMP-9 )with functional outcome after IS. Cristina et al has rst found that MDM2 rs2279744 G allele had increased MDM2 protein expression and was associated with better functional outcome after stroke [21]. Their results revealed that MDM2 rs2279744 determines the functional outcome of patients after stroke through regulating the MDM2-p53 interaction.Subsequently, a study by Yi et al identi ed that interactions among P53 rs1042522, MDM-2 rs2279744, and MMP-9 rs3918242 may jointly increase the risk of poor functional outcome and may be biomarker of predicting poor functional outcome after stroke [22].However, the role of p53 apoptotic pathway related LncRNA genes polymorphism and IS prognosis has not been thoroughly understood.…”

Section: Discussionmentioning

confidence: 98%

Association Between Genetic Variants in the lncRNA–p53 Regulatory Network and Ischemic Stroke Prognosis

Liu

Wang

et al. 2021

Neurotox Res

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Objective Recently, lncRNAs have been demonstrated to be associated with the p53 regulatory pathway,which serve as regulators or effectors. LncRNA-p53 regulatory network play important role in ischemia induced apoptosis and be importance for post-stroke recovery.Method Eight genetic variants in p53 related lncRNA were genotype in 940 patients to explore the association of SNPs in p53 regulatory pathway genes with ischemic stroke prognosis in a northern Chinese population. Long-term outcome and short-term outcome were respectively assessed by the stroke recurrence and modi ed Rankin Scale score at 3 months after stroke.Results We rst identi ed for that p53 rs1042522 and LINC-ROR rs2027701 may be associated with the risk of IS recurrence. In our further cumulative effect analysis, we found that these two polymorphisms may jointly be associated with IS recurrence. Patients carrying 2-4 risk alleles had signi cantly increased risk of IS recurrence compared with those carrying 0-1 risk alleles. In contrast to rs2027701 and rs1042522, other SNP was found to be not associated with IS recurrence. Subsequently, we also found that TUG1 rs2240183 CC genotype was associated with favorable outcome of ischemic stroke after adjusting confound factors. However, the other seven genetic variants in p53 related lncRNA were not associated with functional outcome after stroke.Conclusion P53 rs1042522 and LINC-ROR rs2027701 may have combined effects on IS recurrence and TUG1 rs2240183 may be new biomarker to predict the short-term outcome of ischemic stroke through modulating p53-mediated apoptosis.

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Interactions among variants in P53 apoptotic pathway genes are associated with neurologic deterioration and functional outcome after acute ischemic stroke

Cited by 9 publications

References 44 publications

Persistence of drug therapy is associated with ischemic stroke and other vascular events in high-risk stroke population

Persistence of drug therapy is associated with ischemic stroke and other vascular events in high-risk stroke population

Dataset of allele and genotype frequencies of the three functionally significant polymorphisms of the MMP genes in Russian patients with primary open-angle glaucoma, essential hypertension and peptic ulcer

Association Between Genetic Variants in the lncRNA–p53 Regulatory Network and Ischemic Stroke Prognosis

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