Interaction Policosanol–warfarin on Bleeding Time and Thrombosis in Rats

Carbajal, Daisy; Arruzazabala, M.L.; Valdés, S.; R, Más

doi:10.1006/phrs.1998.0324

Cited by 9 publications

(5 citation statements)

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“…However, in contrast to the studies that have demonstrated benefit of policosanol in animals and humans with or without hypercholesterolemia, there are just as many studies that have demonstrated no effect on blood cholesterol [2,8,9,20 -24], coagulation [13,19,25] or antioxidant activity [11]. The majority of research reported in the literature has been conducted in Cuban laboratories relating to one specific policosanol product from sugar cane (SCP).…”

Section: Introductionmentioning

confidence: 91%

Lack of Effect of Sugar Cane and Sunflower Seed Policosanols on Plasma Cholesterol in Rabbits

Murphy

Saint

Howe

2008

Journal of the American College of Nutrition

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Section: Introductionmentioning

confidence: 91%

Lack of Effect of Sugar Cane and Sunflower Seed Policosanols on Plasma Cholesterol in Rabbits

Murphy

Saint

Howe

2008

Journal of the American College of Nutrition

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“…18,19 On the other hand, the antiplatelet and antithrombotic effects of policosanol have been associated with a reduction of serum thromboxane A 2 levels. 20,21 Negative results on the bone marrow micronucleus assays in rats and mice with oral and intraperitoneal administration of policosanol have been reported. Similar results showed the sister chromatic exchange and micronucleus in in vitro human lymphocytes.…”

Section: Resultsmentioning

confidence: 97%

In Vivo Genotoxic Evaluation of D-003, a Mixture of Very Long Chain Aliphatic Acids

Gámez

González

Rodeiro

et al. 2001

Journal of Medicinal Food

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D-003 is a mixture of very long chain aliphatic acids purified from sugar cane wax with cholesterol-lowering effects. The present study was undertaken to investigate the in vivo cytotoxic and genotoxic potential of D-003 using three established assays: bone marrow micronucleus, sperm morphology, and single cell gel electrophoresis (Comet) assay. In a first experimental series, CEN/NMRI mice (6-8 animals per sex per group) were administered D-003 by gastric gavage at 5, 50, or 500 mg/kg for 90 days, then sacrificed 24 hours after the last administration. The effects on bone marrow micronucleus were evaluated only in female mice. D-003 (5-500 mg/kg) did not increase the frequency of micronucleated polychromatic erythrocytes, nor the ratio of polychromatic to normochromatic erythrocytes, compared with the controls. The assessment of the effects on sperm morphology showed that D-003 did not change the sperm count or the frequency of all types of abnormal head shapes, compared with the controls. In a second series, the micronucleus assay was performed in mice of both sexes given 2,000 mg/kg for 6 days. Likewise, in this series, neither cytotoxic nor genotoxic effects were found. Finally, five male Sprague-Dawley rats were treated with D-003 (1,250 mg/kg) by oral gavage for 90 days, and Comet assay on liver cells was performed. No single-strand breaks or alkali-labile site induction on DNA was observed. These results indicate that D-003 does not show evidence of cytotoxic or genotoxic activity on either somatic or germ cells in rodents.

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“…Studies in animals and humans have shown that policosanol has pleiotropic properties that offer additional benefits in preventing atherosclerosis and complications, such as the inhibition of platelet aggregation [37][38][39][40][41][42][43][44][45] and lipid peroxidation. 24,46 There is some concern about the use of antiplatelet agents for primary CHD prevention.…”

Section: Discussionmentioning

confidence: 99%

“…47 In this study, the treatment groups were sufficiently similar in terms of all variables (ie, demographic, efficacy, and tolerability variables, including concomitant drug use), so that the effects described were considered drug related. Animal studies have shown that among concomitant drug therapies, policosanol exhibits interactions only with aspirin 38,42 and beta-blockers. 48 Thus, policosanol enhances the antiplatelet and antithrombotic effects of aspirin while increasing the antihypertensive effects of beta-blockers, without modifying the decrease in heart rate induced by such drugs.…”

Section: Discussionmentioning

confidence: 99%

Effects of policosanol on borderline to mildly elevated serum total cholesterol levels: a prospective, double-blind, placebo-controlled, parallel-group, comparative study

Castaño

Más

Fernández

et al. 2003

Current Therapeutic Research

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Background: Hypercholesterolemia is a major risk factor for coronary heart disease. Clinical studies have shown that lowering elevated serum cholesterol levels, particularly low-density lipoprotein cholesterol (LDL-C), is beneficial for patients with borderline to mildly elevated serum total cholesterol (TC) levels (5.0-6.0 mmol/L). Policosanol is a cholesterol-lowering drug made from purified sugar cane wax. The therapeutic range of policosanol is 5 to 20 mg/d.Objective: This study investigated the efficacy and tolerability of policosanol 5 mg/d in patients with borderline to mildly elevated serum TC levels.Methods: This 14-week, single-center, prospective, double-blind, placebocontrolled, parallel-group, comparative study was conducted in men and women aged 25 to 75 years with a serum TC level Ն4.8 to Ͻ6.0 mmol/L. After a 6-week run-in period in which patients were placed on therapeutic lifestyle changes, in particular a cholesterol-lowering diet, patients were randomly assigned to receive policosanol 5-mg tablets or placebo tablets once daily with the evening meal for 8 weeks, and the diet was continued throughout the study. Lipid profile variables, safety indicators, adverse events (AEs), and compliance with study medications were assessed.Results: One hundred patients (71 women, 29 men; mean [SD] age, 52 [10] years) entered the study after the dietary run-in period. After 8 weeks of treatment, the mean (SD) serum LDL-C level decreased significantly in the policosanol group (P Ͻ 0.001 vs baseline and placebo) from 3.57 (0.30) mmol/L to 2.86 (0.41) mmol/L (change, Ϫ19.9%). Significantly more patients in the policosanol group The percentage changes were significantly different between the policosanol and placebo groups for serum LDL-C, TC, and HDL-C levels (P Ͻ 0.001, P Ͻ 0.001, and P Ͻ 0.05, respectively), but not for TG. In the placebo group, changes in lipid profile variables from baseline were not significant. Policosanol did not significantly impair any safety indicator and was well tolerated. Three patients (3%) (1 patient [2%] in the policosanol group; 2 patients [4%] in the placebo group) withdrew from the trial, none because of AEs. Two patients (1 patient [2%] each in the policosanol and placebo groups) withdrew from the study because of an unwillingness to return for follow-up; 1 patient (2%) in the placebo group had a change of address and could not be followed up. Overall, 4 patients (4%) (1 patient [2%] in the policosanol group; 3 [6%], placebo) reported AEs; all were mild. Of the patients who received placebo and reported AEs, all 3 (6%) experienced heartburn, and 1 (2%) also experienced dry skin, while the policosanol-treated patient (2%) who reported an AE experienced headache. Conclusions:In this study of patients with borderline to mildly elevated serum TC levels, based on the criterion that Ն70% of policosanol-treated patients reached the LDL-C goal of a decrease Ն15% from baseline whenever this proportion was different with respect to placebo, 8 weeks of treatment with policosanol ...

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Interaction Policosanol–warfarin on Bleeding Time and Thrombosis in Rats

Cited by 9 publications

References 0 publications

Lack of Effect of Sugar Cane and Sunflower Seed Policosanols on Plasma Cholesterol in Rabbits

Lack of Effect of Sugar Cane and Sunflower Seed Policosanols on Plasma Cholesterol in Rabbits

In Vivo Genotoxic Evaluation of D-003, a Mixture of Very Long Chain Aliphatic Acids

Effects of policosanol on borderline to mildly elevated serum total cholesterol levels: a prospective, double-blind, placebo-controlled, parallel-group, comparative study

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