Interaction of vitamin D, homocystein and dental diseases

KUTELMAKH, O.

doi:10.14739/2409-2932.2019.1.159166

Cited by 2 publications

(2 citation statements)

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“…The obtained data on the increase in homocysteine, which was the highest in women with CAD and PMO, can be explained by the formation of endothelium-dependent vasodilation and oxidative stress, the development of lipid peroxidation due to the increased synthesis of superoxide dismutase, thrombogenesis activation, and coagulation [26,27].…”

Section: Imc -Intima-media Complex La -Left Atrium LV -Left Ventricmentioning

confidence: 99%

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The interrelationship of bone and cardiovascular remodeling biomarkers and clinical peculiarities of coronary artery disease in postmenopausal women

et al. 2020

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Objectives: To investigate the interrelationship between bone and cardiovascular remodeling biomarkers and some clinical, laboratory and instrumental parameters of coronary artery disease in postmenopausal women. Material and methods: The double open cross-sectional monocentric clinical study in parallel groups involved 115 women in the postmenopausal period with coronary artery disease (CAD): stable exertional angina of functional class (FC) II-III (mean age 67.07 ±0.92 years). Depending on the bone mineral density (BMD) state, all patients were divided into 3 groups: group 1 (n = 24)-patients with normal BMD (T-criterion more than 1 SD); group 2 (n = 34)-patients with osteopenia (T-criterion from-1 SD to-2.5 SD); group 3 (n = 44)-patients with osteoporosis (T-criterion less than-2.5 SD). The selected control group consisted of 12 relatively healthy women of the corresponding age. All patients underwent cardiovascular and bone remodeling biomarkers' assessment, lipid profile tests, daily monitoring of ECG by Holter, two-dimensional echocardiography and pulsed-wave Doppler. Intima-media complex (IMC) measurement, ultrasound densitometry, and the FRAX algorithm were performed. Results: In women with coronary artery disease and postmenopausal osteoporosis (PMO), there was a significant increase in the level of bone osteoprotegerin (OPG), osteocalcin and vascular remodeling biomarkers (VEGF-A, homocysteine) in parallel with the progression of BMD disorders. The existence of a correlative dependence between osteoprotegerin level and the 10-year risk of fracture of the radial bone (r = 0.46; p < 0.05) was discovered. A probable interrelationship between the OPG, osteocalcin, VEGF-A and homocysteine level and decrease of the T-criterion was observed. An interrelationship between the bone and cardiovascular remodeling biomarkers and atherogenic dyslipidemia, diastolic dysfunction of the left ventricle, dilatation of the left atrium, thickening of the intima-media complex, arrhythmic complications and vegetative imbalance development was proved (p < 0.05), which confirms their clinical and pathogenic role in patients with CAD and PMO. Conclusions: The results obtained prove the existing interrelationship of bone and cardiovascular remodeling biomarkers with the state of bone mineral density and clinical peculiarities of coronary artery disease in postmenopausal women.

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Section: Imc -Intima-media Complex La -Left Atrium LV -Left Ventricmentioning

confidence: 99%

“…In addition, in recent years hyperhomocysteinemia has been considered as a new marker for the risk of osteoporosis and osteoporotic fractures, because hyperhomocysteinemia contributes to the reduction of bone blood supply and is able to influence its biomechanical properties [27,28].…”

Section: Imc -Intima-media Complex La -Left Atrium LV -Left Ventricmentioning

confidence: 99%