Interaction of titanium dioxide nanoparticles with influenza virus

Мазуркова, Н. А.; Spitsyna, Yu. E.; Shikina, N. V.; Ismagilov, Z. R.; Загребельный, С Н; Ryabchikova, E. I.

doi:10.1134/s1995078010050174

Cited by 113 publications

(81 citation statements)

References 6 publications

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“…The efficacy of nano-scale titanium dioxide has been checked against different cancer models [59–60], viral infections [61], bacterial strains [62] as well as for delivering drug to the targeted gene of the damaged cells [63–64]. However, due to the possible toxic effects on the living organisms wide application of TiO 2 nanoparticles has been reduced in some extent also [65].…”

Section: Discussionmentioning

confidence: 99%

Combination of Sonodynamic and Photodynamic Therapy against Cancer Would Be Effective through Using a Regulated Size of Nanoparticles

Miyoshi¹,

Kundu²,

Tuziuti³

et al. 2016

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Nanoparticles have been used for many functional materials in nano-sciences and photo-catalyzing surface chemistry. The titanium oxide nanoparticles will be useful for the treatment of tumor by laser and/or ultrasound as the sensitizers in nano-medicine. We have studied the combination therapy of photo- and sono-dynamic therapies in an animal tumor model. Oral-administration of two sensitizers titanium oxide, 0.2%-TiO2 nanoparticles for sono-dynamic and 1 mM 5-aminolevulinic acid for photodynamic therapies have resulted in the best combination therapeutic effects for the cancer treatment. Our light microscopic and Raman spectroscopic studies revealed that the titanium nanoparticles were distributed inside the blood vessel of the cancer tissue (1–3 μm sizes). Among these nanoparticles with a broad size distribution, only particular-sized particles could penetrate through the blood vessel of the cancer tissue, while other particles may only exhibit the side effects in the model mouse. Therefore, it may be necessary to separate the optimum size particles. For this purpose we have separated TiO2 nanoparticles by countercurrent chromatography with a flat coiled column (1.6 mm ID) immersed in an ultrasonic bath (42 KHz). Separation was performed with a two-phase solvent system composed of 1-butanol-acetic acid-water at a volume ratio of 4:1:5 at a flow rate of 0.1 ml/min. Countercurrent chromatographic separation yielded fractions containing particle aggregates at 31 and 4400 nm in diameter.

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Section: Discussionmentioning

confidence: 99%

Combination of Sonodynamic and Photodynamic Therapy against Cancer Would Be Effective through Using a Regulated Size of Nanoparticles

Miyoshi¹,

Kundu²,

Tuziuti³

et al. 2016

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“…Present antiviral evaluation of TiNPs is only limited to influenza virus (H3N2) and certain bacteriophages such as MS2, PRD1, ɸX174, Fr and many others. [74][75][76] Moreover, the existing toxicity evaluations of the NPs though cannot completely eliminate health risks therefore, their biomedical application as an antiviral agent is questionable. 77 But considering beneficial role of TiNPs in biomedical sector, its antiviral activity however, needs to be perfectly conceptualized in animal models too.…”

Section: Titanium Nanoparticles (Tinps)mentioning

confidence: 99%

Nano-based approach to combat emerging viral (NIPAH virus) infection

Kerry

Malik

Redda

et al. 2019

Nanomedicine: Nanotechnology, Biology and Medicine

104

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Emergence of new virus and their heterogeneity are growing at an alarming rate. Sudden outburst of Nipah virus (NiV) has raised serious question about their instant management using conventional medication and diagnostic measures. A coherent strategy with versatility and comprehensive perspective to confront the rising distress could perhaps be effectuated by implementation of nanotechnology. But in concurrent to resourceful and precise execution of nano-based medication, there is an ultimate need of concrete understanding of the NIV pathogenesis. Moreover, to amplify the effectiveness of nano-based approach in a conquest against NiV, a list of developed nanosystem with antiviral activity is also a prerequisite. Therefore the present review provides a meticulous cognizance of cellular and molecular pathogenesis of NiV. Conventional as well several nano-based diagnosis experimentations against viruses have been discussed. Lastly, potential efficacy of different forms of nano-based systems as convenient means to shield mankind against NiV has also been introduced.

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“…Additionally, nanosized titanium dioxide (TiO2-nanoparticles or TNPs) have been proven to act as effective photocatalysts and shown to have both bactericidal and virucidal properties [15]. The anti-viral effect of TiO2 has been demonstrated against influenza virus [16], which is transmitted via aerosol and causes respiratory tract infection, similar to COVID-19 [17]. However, the anti-viral efficacy of TiO2 against human coronavirus remains largely unknown.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Inactivation of Human Coronavirus by Titania Nanoparticle Coatings and UVC Radiation: Throwing Light on SARS-CoV-2

Khaiboullina

Uppal

Dhabarde

et al. 2020

Preprint

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The newly identified pathogenic human coronavirus, SARS-CoV-2, led to an atypical pneumonia-like severe acute respiratory syndrome (SARS) outbreak called coronavirus disease 2019 (COVID-19). Currently, nearly 23 million cases have been confirmed worldwide with the highest COVID-19 cases been confirmed in the United States. As there is no vaccine or any effective interventions, massive efforts to create a potential vaccine to combat COVID-19 is underway. In the meantime, safety precautions and effective disease control strategies appear to be vital for preventing the virus spread in the public places. Due to the longevity of the virus on smooth surfaces, photocatalytic properties of self-disinfecting/cleaning surfaces appear to be a promising tool to help guide disinfection policies to control infectious SAR-CoV-2 spread in high-traffic areas such as hospitals, grocery stores, airports, schools, and stadiums. Here, we explored the photocatalytic properties of nanosized TiO2 (TNPs) as induced by the UV radiation, towards virus deactivation. Our preliminary results using close genetic relative of SAR-CoV-2, HCoV-NL63, showed the virucidal efficacy of photoactive TNPs deposited on glass coverslips, as examined by quantitative RT-PCR and virus culture assays. Efforts to extrapolate the underlying concepts described in this study to SARS-CoV-2 are currently underway.

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Interaction of titanium dioxide nanoparticles with influenza virus

Cited by 113 publications

References 6 publications

Combination of Sonodynamic and Photodynamic Therapy against Cancer Would Be Effective through Using a Regulated Size of Nanoparticles

Combination of Sonodynamic and Photodynamic Therapy against Cancer Would Be Effective through Using a Regulated Size of Nanoparticles

Nano-based approach to combat emerging viral (NIPAH virus) infection

In Vitro Inactivation of Human Coronavirus by Titania Nanoparticle Coatings and UVC Radiation: Throwing Light on SARS-CoV-2

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