Interaction of sulfated polysaccharides with intestinal Bacteroidales plays an important role in its biological activities

Sun, Xiao; Liu, Yili; Jiang, Pingrui; Song, Shuang; Ai, Chunqing

doi:10.1016/j.ijbiomac.2020.12.024

Cited by 20 publications

(9 citation statements)

References 50 publications

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“…Members of the genus Rhodococcus, with versatile abilities to degrade various organic compounds, are able to generate triacylglycerols [ 62 , 63 ]. Intestinal Bacteroidales can play important roles in the bioactivities of sulfated polysaccharides [ 64 ]. In the current study, the abundances of Barnesiella , Anaerostipes , Merdibacter , Caproiciproducens , Gordonibacter , Roseburia , Rhodococcus , and unclassified_o_Bacteroidales in the cecum of broilers were significantly increased by the appropriate addition of BFMA in diets.…”

Section: Discussionmentioning

confidence: 99%

Bio-Fermented Malic Acid Facilitates the Production of High-Quality Chicken via Enhancing Muscle Antioxidant Capacity of Broilers

Qiu

Zhang

et al. 2022

Antioxidants

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Malic acid, an intermediate of the tricarboxylic acid (TCA) cycle, is a promising acidifier with strong antioxidant capacity. This study aimed to evaluate the effects of bio-fermented malic acid (BFMA) on promoting the body health, performance and meat quality of broilers. A total of 288 one-day-old Arbor Acres male broiler chicks were randomly divided into four treatments with six replicates in each. Every replicate had 12 chicks. Four experimental diets contained 0, 4, 8, and 12 g/kg BFMA, respectively. During the 42-day trial, mortality was recorded daily, feed intake and body weight of each replicate being recorded every week. Blood samples were collected on days 21 and 42 for chemical analysis. After slaughter at the age of 42 days, the carcass traits and meat quality of the broilers were measured, breast muscle samples were collected for the determination of antioxidant capacity, and cecal digesta were pretreated for microbiota analysis. Dietary BFMA significantly increased feed intake and daily gain, and decreased feed conversion ratio and death and culling ratio of the broilers at the earlier stage. The water-holding capacity of breast muscle indicated by the indexes of dripping loss and cooking loss was significantly increased by BFMA, especially at the addition level of 8 g/kg. Dietary BFMA significantly decreased the activity of superoxide dismutase and contents of immunoglobulin A and glutathione, and increased contents of immunoglobulin G and M in serum of the broilers. The contents of glutathione, inosinic acid, and total antioxidant capacity and the activities of glutathione-Px and superoxide dismutase were significantly increased by dietary BFMA, with the level of 8 g/kg best. The diversity of cecal microbiota of broilers was obviously altered by BFMA. In conclusion, as one of several acidifiers, addition of BFMA in diets could improve the performance and body health of broilers, probably by reinforcing immunity and perfecting cecal microbiota structure. As one of the intermediates of the TCA cycle, BFMA increases the water-holding capacity of breast muscle of broilers, probably through reducing lactate accumulates and enhancing antioxidant capacity.

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Section: Discussionmentioning

confidence: 99%

Bio-Fermented Malic Acid Facilitates the Production of High-Quality Chicken via Enhancing Muscle Antioxidant Capacity of Broilers

Qiu

Zhang

et al. 2022

Antioxidants

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“…However, recent studies showed that small molecular weight MSPs (<30 kDa) could be degraded by human gut microbes and produce large amounts of SCFAs, which regulate the balance of gut microbiota [78]. MSPs from pacific abalone could be degraded by intestinal Bacteroidetes in an in vitro fermentation model, and it was species dependent [79]. These different results may have something to do with the fact that the gut microbiota of the Chinese, who traditionally consume kelp and other algae, is more suitable for the degradation of MSPs.…”

Section: Utilization Of Msps By Gut Microbiotamentioning

confidence: 99%

Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review

et al. 2021

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Metabolic syndrome is the pathological basis of cardiovascular and cerebrovascular diseases and type 2 diabetes. With the prevalence of modern lifestyles, the incidence of metabolic syndrome has risen rapidly. In recent years, marine sulfate polysaccharides (MSPs) have shown positive effects in the prevention and treatment of metabolic syndrome, and they mainly come from seaweeds and marine animals. MSPs are rich in sulfate and have stronger biological activity compared with terrestrial polysaccharides. MSPs can alleviate metabolic syndrome by regulating glucose metabolism and lipid metabolism. In addition, MSPs prevent and treat metabolic syndrome by interacting with gut microbiota. MSPs can be degraded by gut microbes to produce metabolites such as short chain fatty acids (SCFAs) and free sulfate and affect the composition of gut microbiota. The difference between MSPs and other polysaccharides lies in the sulfation pattern and sulfate content, therefore, which is very important for anti-metabolic syndrome activity of MSPs. This review summarizes the latest findings on effects of MSPs on metabolic syndrome, mechanisms of MSPs in treatment/prevention of metabolic syndrome, interactions between MSPs and gut microbiota, and the role of sulfate group and sulfation pattern in MSPs activity. However, more clinical trials are needed to confirm the potential preventive and therapeutic effects on human body. It may be a better choice to develop new functional foods containing MSPs for dietary intervention in metabolic syndrome.

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“…The gut microbiota is the core organ of polysaccharide metabolism in vivo. Non-starch polysaccharides are hard to be digested and absorbed by human body, but can serve as food by the gut microbiota during anaerobic fermentation [10,14]. Their metabolites, such as short-chain fatty acids (SCFAs), can provide nutrition to intestinal epithelial cells and stimulate the expression of immune related genes, which is crucial to produce host antibody and boost immune response [15,16].…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide from Patinopecten yessoensis Skirt Boosts Immune Response via Modulation of Gut Microbiota and Short-Chain Fatty Acids Metabolism in Mice

Qin

Cheng

et al. 2021

Foods

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Polysaccharide from marine shellfish has various bioactivities. In this study, the effects of polysaccharide from Patinopecten yessoensis skirt (PS) on boosting immune response in mice were evaluated, and the potential mechanisms were explored. The results showed that PS administration effectively increased the serum IgG and IgM levels, implying that PS had immune response-boosting properties. Moreover, PS administration could modulate the composition of the gut microbiota, and significantly improve short-chain fatty acids (SCFAs) metabolism, especially butyrate metabolism. Of note, the expression of the Tlr2, Tlr7, MyD88, Tnfa, and Il1b genes in toll-like receptor (TLR) signaling pathway was significantly increased. In summary, PS could boost immune response by modulating the gut microbiota and SCFAs metabolism correlating with the activation of the TLR signaling pathway. Therefore, PS can be developed as a special ingredient for functional product.

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Interaction of sulfated polysaccharides with intestinal Bacteroidales plays an important role in its biological activities

Cited by 20 publications

References 50 publications

Bio-Fermented Malic Acid Facilitates the Production of High-Quality Chicken via Enhancing Muscle Antioxidant Capacity of Broilers

Bio-Fermented Malic Acid Facilitates the Production of High-Quality Chicken via Enhancing Muscle Antioxidant Capacity of Broilers

Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review

Polysaccharide from Patinopecten yessoensis Skirt Boosts Immune Response via Modulation of Gut Microbiota and Short-Chain Fatty Acids Metabolism in Mice

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