Interaction of stable colloidal nanoparticles with cellular membranes

Mahmoudi, Morteza; Meng, Jie; Xue, Xue; Lü, Xing; Rahman, Mohammad Rezaur; Pfeiffer, Christian; Hartmann, Raimo; Rivera-Gil, Pilar; Pelaz, Beatriz; Parak, Wolfgang J.; Pino, Pablo del; Carregal‐Romero, Susana; Kanaras, Antonios G.; Selvan, Subramanian Tamil

doi:10.1016/j.biotechadv.2013.11.012

Cited by 62 publications

(71 citation statements)

References 214 publications

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“…This is justified and common for most of the abovementioned problems; e.g. impact of rain and wind on transmission lines and stay cables [19,20], and colloids on membranes [18] is usually modeled as time-periodic. Expanding f in a trigonometric Fourier series gives:…”

Section: Governing Equationsmentioning

confidence: 99%

“…This simple system is a generic model for various relevant problems, e.g. interaction between membranes and colloids in biochemistry [18], oscillations of transmission lines under action of rain and wind [19], and dynamics of suspension bridges and stay cables [20]. Moreover, it serves to reveal general effects of continuous spatially periodic modulations on oscillations of bounded structures subjected to distributed loading, and illustrates possible advantages and disadvantages of the proposed technique of vibration suppression.…”

Section: Introductionmentioning

confidence: 99%

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Vibration suppression for strings with distributed loading using spatial cross-section modulation

Sorokin

Thomsen

2015

Journal of Sound and Vibration

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Document VersionPeer reviewed version Link back to DTU Orbit Citation (APA): Sorokin, V., & Thomsen, J. J. (2015). Vibration suppression for strings with distributed loading using spatial cross-section modulation. Journal of Sound and Vibration, 335, 66-77. DOI: 10.1016/j.jsv.2014.09.028 Vibration suppression for strings with distributed loading using spatial cross-section modulation Abstract A problem of vibration suppression in any preassigned region of a bounded structure subjected to action of an external time-periodic load which is distributed over its domain is considered. A passive control is applied, in that continuous spatially periodic modulations of structural parameters are used as a means for vibration suppression. As an example, stationary vibrations of a string under action of a distributed time-periodic load are studied. This system in a simplified form models such processes as interaction between membranes and colloids, oscillations of transmission lines under action of rain and wind, and dynamics of suspension bridges and stay cables. Suppression of vibration in predefined regions of the string is performed by continuous spatial modulation of its cross-section. For analyzing the problem considered a novel approach named the method of varying amplitudes is employed. This approach is applicable for solving differential equations without a small parameter, and may be considered as a natural continuation of the classical methods of harmonic balance and averaging. As a result, optimal parameters for the string cross-sectional area modulation are determined for the cases of harmonically, uniformly and arbitrarily distributed load, which allows for completely suppressing or considerably reducing vibration in the prescribed part of the string (compared to the case without modulation). vibration suppression; bounded structure; distributed loading; continuous spatially periodic modulation; the method of varying amplitudes.

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Section: Governing Equationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vibration suppression for strings with distributed loading using spatial cross-section modulation

Sorokin

Thomsen

2015

Journal of Sound and Vibration

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“…The first contact between NPs and living organisms occurs at the level of the cell membrane, thus understanding this interaction is a critical step to design safer and more efficient NPs as well as to predict possible toxicity effects. [1][2][3] Studying these interactions is a challenging topic due to the complexity and heterogeneity of the cell membrane. 1,4 Simpler models representative of the biological membranes provide a useful tool to perform focused studies and unravel the physical and chemical nature of NP-membrane interactions.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] Studying these interactions is a challenging topic due to the complexity and heterogeneity of the cell membrane. 1,4 Simpler models representative of the biological membranes provide a useful tool to perform focused studies and unravel the physical and chemical nature of NP-membrane interactions. 3 In fact, model membranes are versatile systems whose composition and structure can be precisely controlled and customized capturing essential aspects of the real membranes, without the influence of cell metabolism and growth.…”

Section: Introductionmentioning

confidence: 99%

The effect of the protein corona on the interaction between nanoparticles and lipid bilayers

Silvio

Maccarini

Parker

et al. 2017

Journal of Colloid and Interface Science

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2 HypothesisIt is known that nanoparticles (NPs) in a biological fluid are immediately coated by a protein corona (PC), composed of a hard (strongly bounded) and a soft (loosely associated) layers, which represents the real nano-interface interacting with the cellular membrane in vivo. In this regard, supported lipid bilayers (SLB) have extensively been used as relevant model systems for elucidating the interaction between biomembranes and NPs. Herein we show how the presence of a PC on the NP surface changes the interaction between NPs and lipid bilayers with particular care on the effects induced by the NPs on the bilayer structure. ExperimentsIn the present work we combined Quartz Crystal Microbalance with Dissipation Monitoring (QCM-D) and Neutron Reflectometry (NR) experimental techniques to elucidate how the NPmembrane interaction is modulated by the presence of proteins in the environment and their effect on the lipid bilayer. FindingsOur study showed that the NP-membrane interaction is significantly affected by the presence of proteins and in particular we observed an important role of the soft corona in this phenomenon. KEYWORDSsupported lipid bilayer, protein corona nanoparticles, quartz crystal microbalance, neutron reflectometry, soft corona, hard corona. ABBREVIATIONNPs nanoparticles; SLB supported lipid bilayer; PC protein corona; QCM-D quartz crystal microbalance with dissipation; NR neutron reflectometry; PS polystyrene; PBS phosphate buffered saline; FBS fetal bovine serum; HC hard corona; SC soft corona; DOPC 1,2-Dioleoylsn-glycero-3-phosphocholine; SLD scattering length density; APM area per molecule; 4MW 4 matching water; SMW silicon matching water; LUV large unilamellar vesicle; GUV giant unilamellar vesicle; DPPC Dipalmitoyl-phosphatidyl-choline.3

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“…Also, whether the particles are agglomerated or not on the biological fluids [33,101] could strongly modify their uptake. Moreover, nanoparticles can induce conformational changes in proteins, affecting their physiological function [147].…”

Section: Protein Coronamentioning

confidence: 99%

Edible Bio-Based Nanostructures: Delivery, Absorption and Potential Toxicity

et al. 2015

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The development of bio-based nanostructures as nanocarriers of bioactive compounds to specific body sites has been presented as a hot topic in food, pharmaceutical and nanotechnology fields. Food and pharmaceutical industries seek to explore the huge potential of these nanostructures, once they can be entirely composed of biocompatible and non-toxic materials. At the same time, they allow the incorporation of lipophilic and hydrophilic bioactive compounds protecting them against degradation, maintaining its active and functional performance. Nevertheless, the physicochemical properties of such structures (e.g., size and charge) could change significantly their behavior in the gastrointestinal (GI) tract. The main challenges in the development of these nanostructures are the proper characterization and understanding of the processes occurring at their surface, when in contact with living systems. This is crucial to 2 understand their delivery and absorption behavior as well as to recognize potential toxicological effects. This review will provide an insight into the recent innovations and challenges in the field of delivery via GI tract using bio-based nanostructures. Also, an overview of the approaches followed to ensure an effective deliver (e.g., avoiding physiological barriers) and to enhance stability and absorptive intestinal uptake of bioactive compounds will be provided. Information about nanostructures' potential toxicity and a concise description of the in vitro and in vivo toxicity studies will also be given.

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Interaction of stable colloidal nanoparticles with cellular membranes

Cited by 62 publications

References 214 publications

Vibration suppression for strings with distributed loading using spatial cross-section modulation

Vibration suppression for strings with distributed loading using spatial cross-section modulation

The effect of the protein corona on the interaction between nanoparticles and lipid bilayers

Edible Bio-Based Nanostructures: Delivery, Absorption and Potential Toxicity

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