2003
DOI: 10.1200/jco.2003.12.136
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Interaction of Splenectomy and Perioperative Blood Transfusions on Prognosis of Patients With Proximal Gastric and Gastroesophageal Junction Cancer

Abstract: Our study suggests an interaction of blood transfusion and splenectomy in their effect on survival paralleling the findings in the transplantation literature. The adverse effect of allogeneic blood transfusion on prognosis in patients with gastric cancer seems to be associated with the presence of an intact spleen and is abrogated by its absence.

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Cited by 42 publications
(44 citation statements)
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“…In a retrospective study of patients undergoing surgery for proximal gastric cancer, the association between increased recurrence and decreased survival rates in those who received blood transfusions was negated when splenectomy was also performed 10 . This suggests an immunological mechanism for the adverse effect of transfusion.…”
Section: Introductionmentioning
confidence: 98%
“…In a retrospective study of patients undergoing surgery for proximal gastric cancer, the association between increased recurrence and decreased survival rates in those who received blood transfusions was negated when splenectomy was also performed 10 . This suggests an immunological mechanism for the adverse effect of transfusion.…”
Section: Introductionmentioning
confidence: 98%
“…In this study, we classified cancers into diffuse type (por1, por2, sig, muc) and intestinal type (pap, tub1, tub2). Perioperative transfusion was also included as it has been reported to be a significant prognostic factor in advanced gastric cancer [19,20]. It was defined as allogeneic blood transfusion during surgery or in the first 2 postoperative days.…”
Section: Clinicopathological Factorsmentioning
confidence: 99%
“…Eine längere Lagerungszeit der Blutkonserven ist dabei mit einem signifikanten Anstieg der infektiösen Komplikationen assoziiert [49]. Interessanterweise scheint der negative Einfluss auf das Überleben mit einer intakten Milzfunktion assoziiert zu sein [69]. Der genaue Mechanismus der dargestellten Effekte ist jedoch unklar; beispielsweise ist ungeklärt, welche Blutkomponente (z.…”
Section: Direkter Einfluss Perioperativer Maßnahmen Auf Das Behandlununclassified