Interaction of Splenectomy and Perioperative Blood Transfusions on Prognosis of Patients With Proximal Gastric and Gastroesophageal Junction Cancer

Weitz, Jürgen; D’Angelica, Michael I.; Gönen, Mithat; Klimstra, David S.; Coit, Daniel G.; Brennan, Murray F.; Karpeh, Martin S.

doi:10.1200/jco.2003.12.136

Cited by 42 publications

(44 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a retrospective study of patients undergoing surgery for proximal gastric cancer, the association between increased recurrence and decreased survival rates in those who received blood transfusions was negated when splenectomy was also performed 10 . This suggests an immunological mechanism for the adverse effect of transfusion.…”

Section: Introductionmentioning

confidence: 98%

Effect of blood transfusion on outcome after pancreaticoduodenectomy for exocrine tumour of the pancreas

Yeh

Gönen

Tomlinson

et al. 2007

British Journal of Surgery

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 98%

Effect of blood transfusion on outcome after pancreaticoduodenectomy for exocrine tumour of the pancreas

Yeh

Gönen

Tomlinson

et al. 2007

British Journal of Surgery

View full text Add to dashboard Cite

show abstract

“…In this study, we classified cancers into diffuse type (por1, por2, sig, muc) and intestinal type (pap, tub1, tub2). Perioperative transfusion was also included as it has been reported to be a significant prognostic factor in advanced gastric cancer [19,20]. It was defined as allogeneic blood transfusion during surgery or in the first 2 postoperative days.…”

Section: Clinicopathological Factorsmentioning

confidence: 99%

Lymph node ratio is a critical prognostic predictor in gastric cancer treated with S-1 chemotherapy

et al. 2013

View full text Add to dashboard Cite

Background S-1 is an oral anticancer drug widely used in postoperative adjuvant therapy for patients in Japan with stage II/III gastric cancer. Candidates for more intense adjuvant treatments need to be identified, particularly among patients with stage III cancer. Methods Univariate and multivariate analyses were conducted for patients with stage II/III gastric cancer who underwent surgery and received S-1 postoperatively between 2000 and 2010.Results Factors indicating poor prognosis identified by univariate analysis include male sex (P = 0.022), age C67 years (P = 0.021), intestinal-type histology (P = 0.049), lymph node ratio C16.7 % (P \ 0.0001), open surgery (P = 0.039), as well as the 13th JGCA stage (P \ 0.0001) and the 14th JGCA/7th International Union Against Cancer (UICC) stage (P \ 0.0001). Multivariate analysis revealed that lymph node ratio C16.7 % and intestinal-type histology were significant as predictors of prognosis, independent from the pathological stages. Based on these and other findings, stage IIIC cancer on the 14th JGCA/7th UICC stage system in combination with the lymph node ratio could identify patients with extremely high risk for recurrence Conclusions Our current findings suggest that lymph node ratio C16.7 % in combination with the new staging system could be a useful prognostic indicator in advanced gastric cancer. Because these high-risk patients cannot be identified preoperatively by any diagnostic tool, further improvement in postoperative adjuvant therapy is warranted.

show abstract

“…Eine längere Lagerungszeit der Blutkonserven ist dabei mit einem signifikanten Anstieg der infektiösen Komplikationen assoziiert [49]. Interessanterweise scheint der negative Einfluss auf das Überleben mit einer intakten Milzfunktion assoziiert zu sein [69]. Der genaue Mechanismus der dargestellten Effekte ist jedoch unklar; beispielsweise ist ungeklärt, welche Blutkomponente (z.…”

Section: Direkter Einfluss Perioperativer Maßnahmen Auf Das Behandlununclassified

Stellenwert der Anästhesie in multimodalen onkologischen Therapiekonzepten

et al. 2006

View full text Add to dashboard Cite

Patients with malignant diseases are increasingly being treated with multimodal therapeutical concepts based on the three major modalities surgery, radiotherapy and chemotherapy. The perioperative period is crucial within this multimodal concept as the prognosis of patients may be directly influenced by perioperative measures. In addition, it is of major importance to avoid complications in the perioperative phase, as these might worsen the prognosis of the patient and in order to prevent a delay in the beginning of planned adjuvant therapies. These aspects demonstrate the important role of anesthesia in the treatment of patients with cancer. Further studies defining the relevance of anesthesiologic measures in oncologic patients are needed.

show abstract

Interaction of Splenectomy and Perioperative Blood Transfusions on Prognosis of Patients With Proximal Gastric and Gastroesophageal Junction Cancer

Cited by 42 publications

References 34 publications

Effect of blood transfusion on outcome after pancreaticoduodenectomy for exocrine tumour of the pancreas

Effect of blood transfusion on outcome after pancreaticoduodenectomy for exocrine tumour of the pancreas

Lymph node ratio is a critical prognostic predictor in gastric cancer treated with S-1 chemotherapy

Stellenwert der Anästhesie in multimodalen onkologischen Therapiekonzepten

Contact Info

Product

Resources

About