Effect of blood transfusion on outcome after pancreaticoduodenectomy for exocrine tumour of the pancreas

Abstract

In patients with exocrine tumours of the pancreas, blood transfusion should be avoided when possible. Preoperative risk factors can identify patients who are likely to require transfusion and would therefore benefit most from blood conservation methods.

Detrimental Effect of Postoperative Complications on Oncologic Efficacy of R0 Pancreatectomy in Ductal Adenocarcinoma of the Pancreas

“…Law et al 17,26 also suggested that an altered immune response associated with sepsis, stress, and inflammatory responses following complications might contribute to the growth and proliferation of residual tumor cells in colorectal cancer patients. Recently, Yeh et al 27 examined survival in patients with pancreatic cancer who received blood transfusions in association with pancreaticoduodenectomy. Postoperative transfusion remained a predictor of survival that was independent of both nodal and margin status.…”

Impact of fluid resuscitation on major adverse events following pancreaticoduodenectomy

“…This is expected as multiple previous studies have demonstrated a similar association between perioperative transfusion and adverse events following PD. 18,19 Furthermore, 10.7% of the patients who experienced a major adverse event suffered from postoperative bleeding.…”

Accumulation of PRO-Cancer Cytokines in the Plasma Fraction of Stored Packed Red Cells

“…[1][2][3][4][5][6][7] Although a direct causal mechanism has not been elucidated, blood transfusion has been shown to induce anergy, Tsuppressor cells, and clonal deletion. 8 Underlying clinical variables surrounding the need for blood transfusion likely confound patient outcomes and interpretation of results.…”