Interaction of serotonin with the catecholamines—I

VanderWende, Christina; Johnson, J.C.

doi:10.1016/0006-2952(70)90295-9

Cited by 11 publications

(3 citation statements)

References 3 publications

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“…Although label-free detection of DA and 5-HT is reported in various works [39,40,41,42,43,44,45,46], only a single study suggests their potential chemical interaction with each other and the formation of a new compound [33]. This is surprising, considering their biological proximity and physiological co-existence within the striatum [28,29], as well as their chemical similarity.…”

Section: Resultsmentioning

confidence: 99%

“…Independently, DA and 5-HT have been extensively studied and progress has been made in understanding their roles in neuronal systems [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17]. However, much less has been reported in the literature regarding their intimate and complex relationship [18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33], especially from neurochemical perspectives [33,34]. Consequently, there is still a scientific need for understanding their interdependent chemical effects, and this has implications for the efficacy of adequate drug administration in the treatment of behavioral and mood disorder diseases.…”

Section: Introductionmentioning

confidence: 99%

“…From a molecular neurochemical viewpoint, both dopamine and serotonin contain structural features, such as hydroxyl groups, that make them good model compounds for studying intermolecular interactions among themselves, as well as with certain proteins [33,34,35]. However, while theoretical models were constructed and reported for such interactions [33,34,35], a direct correspondence between these models and experimental results through optical methods was not yet established at physiological levels. A major drawback here is that the majority of such analyses involve tagging analytes with a variety of fluorescent dyes or attaching them to different nanoparticles [36,37,38].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Simultaneous Detection of Dopamine and Serotonin—A Comparative Experimental and Theoretical Study of Neurotransmitter Interactions

Manciu

Ciubuc

et al. 2018

Biosensors

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With the goal of accurately detecting and quantifying the amounts of dopamine (DA) and serotonin (5-HT) in mixtures of these neurotransmitters without using any labelling, we present a detailed, comparative computational and Raman experimental study. Although discrimination between these two analytes is achievable in such mixtures for concentrations in the millimolar range, their accurate quantification remains unattainable. As shown for the first time in this work, the formation of a new composite resulting from their interactions with each other is the main reason for this lack of quantification. While this new hydrogen-bonded complex further complicates potential analyte discrimination and quantification at concentrations characteristic of physiological levels (i.e., nanomolar concentrations), it can also open new avenues for its use in drug delivery and pharmaceutical research. This remark is based not only on chemical interactions analyzed here from both theoretical and experimental approaches, but also on biological relationship, with consideration of both functional and neural proximity perspectives. Thus, this research constitutes an important contribution toward better understanding of neural processes, as well as toward possible future development of label-free biosensors.

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