Interaction of Polymer Aggregates Based on Stearoyl-poly-N-vinylpyrrolidone with Blood Components

Abstract

Stearoyl-poly-N-vinylpyrrolidone (PVP-stear) of various molecular weights (M(n) = 1500-5500) self-assemble in aqueous medium. Particles prepared from PVP-stear were characterized in terms of shape and size distribution, and the mechanical stability of the particles was studied. The interaction of PVP-stear and its aggregates with blood components was investigated. Aggregates formed by the polymers with M(n) = 1500-3500 in the presence of human serum are stable. The direct lytic action of PVP-stear preparations was studied using sheep and human erythrocytes. The influence of PVP-stear aggregates on the activation of complement system both on classical and alternative pathways was examined. The aggregates prepared from PVP-stear of various molecular weights had no effect on the activation of the complement system.

Self‐assembled amphiphilic poly‐N‐vinylpyrrolidone nanoparticles as carriers for hydrophobic drugs: Stability aspects

“…In this study, we investigated the structure, physicochemical properties, and mechanical, thermodynamic, and kinetic stability of self‐assembled nanoparticles prepared from amphiphilic derivatives of poly‐ N ‐vinylpyrrolidone (PVP). PVP is a well‐known water‐soluble and biocompatible polymer . The PVP amide group easily forms hydrogen bonds and as a result, PVP has a high binding affinity for several small and large molecules .…”

Self-assembling nanoscaled drug delivery systems composed of amphiphilic poly-N-vinylpyrrolidones

“…Modification of liposomes by amphiphilic PVP leads to an increase of their circulation time in the blood of experimental mice and prevents fast capture of liposomes by the reticulo-endothelial system (RES) [10]. Interaction of amphiphilic PVP aggregates with blood components and several proteins was studied in [14,15]. It should be also mentioned that amphiphilic PVPs possess greater biocompatibility that PEG end-capped amphiphiles.…”

Turn‐on fluorogenic and chromogenic detection of cations in complete water media with poly(N‐vinyl pyrrolidone) bearing rhodamine B derivatives as polymeric chemosensor

“…As we all know, polyvinylpyrrolidone has the advantage of excellent water solubility, nonionic, good film forming, biocompatibility, and extremely low cytotoxicity . Therefore, N ‐vinylpyrrolidone is quite appropriate to be selected as the hydrophilic monomer to copolymerize with the fluorophore having acryloyl group.…”