Interaction of passive smoking with GST (GSTM1, GSTT1, and GSTP1) genotypes in the risk of cervical cancer in India

Sobti, Ranbir Chander; Kaur, Swaran; Kaur, Parampreet; Singh, Jagmohan; Gupta, Indu; Jain, Veena; Nakahara, A

doi:10.1016/j.cancergencyto.2005.10.001

Cited by 53 publications

(46 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…According to the exclusion criteria, 15 articles were excluded including 5 articles containing overlapping population [7][8][9][10][11], 8 precancerous lesions included in the cases [12][13][14][15][16][17][18][19], 2 without sufficient data [20][21]. At last, data were available from 16 individual case-control studies [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37], Table 1 presented characteristics of these 16 case-control studies (a total of 1,627 CC cases and 2,161 controls). 14 studies on GSTM1 polymorphism (a total of 1,514 CC cases and 1,907 controls), 12 studies on GSTT1 polymorphism (a total of 1,187 CC cases and 1,590 controls), and 6 studies on GSTM1-GSTT1 interaction analysis (a total of 791 CC cases and 767controls) were included in the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

Glutathione S-transferase M1 and T1 polymorphisms and cervical cancer risk: A meta-analysis

Wang

Wang²,

Jx³

et al. 2011

neo

View full text Add to dashboard Cite

There were some studies on the associations between Glutathione S-transferase M1 (GSTM1) and Glutathione S-transferase T1 (GSTT1) polymorphisms and cervical cancer (CC) risk, but the results were inconsistent. Thus, a meta-analysis was performed.The electronic databases PubMed, Science Direct, CBM, and CNKI were searched for possible studies. Finally, 16 studies (1,627 cases and 2,161 controls) were included. For the GSTM1 and GSTT1 polymorphisms, the unadjusted odds ratios (OR) and 95% confidence intervals (95% CI) from each study were used to estimate summary OR. Subgroup analyses by ethnicity and histological type of CC were also performed.For the GSTM1 polymorphism, the null genotype of GSTM1 was associated with an increased CC risk in total population (OR=1.32, 95% CI=1.06-1.66). Similar association was found in Asians (OR=1.47, 95% CI=1.11-1.94), but not in Caucasians (OR=0.96, 95% CI=0.73-1.27). For the GSTT1 polymorphism, the null genotype of GSTT1 was not statistically significantly associated with CC risk in total population (OR=1.36, 95% CI=0.97-1.90). This result was also found in Asians (OR=1.27, 95% CI=0.87-1.85) and Caucasians (OR=1.09, 95% CI= 0.66-1.79), but not in Latinos (OR=4.58, 95% CI= 2.04-10.28). For the GSTM1/GSTT1 interaction analysis, the dual null genotypes of GSTM1/GSTT1 were significantly associated with increased CC risk in total population (OR=1.77, 95% CI= 1.14-2.75), and all the six studies were from Asia. For subgroup analyses by histological type of CC, the three aspects of the analyses above were all not significantly associated with CC risk in squamous cell carcinoma and adenocarcinoma, respectively.The null genotype of GSTM1 and the dual null genotypes of GSTM1/GSTT1 were risk factors in CC, and the null genotype of GSTT1 was not associated with CC risk.

show abstract

Section: Resultsmentioning

confidence: 99%

Glutathione S-transferase M1 and T1 polymorphisms and cervical cancer risk: A meta-analysis

Wang

Wang²,

Jx³

et al. 2011

neo

View full text Add to dashboard Cite

show abstract

“…Sobti et al 4 did not show any risk of developing cervical cancer with GSTM1 (-/-) and T1 (-/-) genotypes taken together. Although the P-value was not significant, the present study showed a 2.75-times higher risk of developing cervical cancer with the GSTM1/T1 (-/-) double combination (Table 4).…”

Section: Discussionmentioning

confidence: 99%

“…However, all HPV infected women do not develop cervical cancer. This indicates the role of additional etiological co-factors such as marriage age, early and multiple child birth, low socio-economic status and heavy cigarette smoking 4 . HPV infected women exposed to kitchen smoke from wood for 35 years or more were found to be at 5.69 times higher risk of developing cervical cancer 5 .…”

Section: Introductionmentioning

confidence: 99%

Association of Glutathione S-transferase (GSTM1, GSTT1 and GSTP1) polymorphisms and passive smoking in cervical cancer cases from North India

Abbas¹,

Srivastava²,

Imran³

et al. 2013

Int Jour of Biomed Res

View full text Add to dashboard Cite

“…A total of 10 new studies have been identified: one cohort study (Table 2.11 available at http://monographs.iarc.fr/ENG/Monographs/ vol100E/100E-02-Table2.11.pdf) and nine casecontrol studies (Buckley et al, 1981;Brown et al, 1982;Hellberg et al, 1986;Hirose et al, 1996;Coker et al, 2002;Wu et al, 2003;Tay & Tay, 2004;Sobti et al, 2006;Tsai et al, 2007;Table 2.12 available at http://monographs.iarc.fr/ ENG/Monographs/vol100E/100E-02-Table2.12. pdf).…”

Section: Cancer Of the Cervixmentioning

confidence: 99%

“…Only Coker et al (2002) and Tsai et al (2007) controlled for HPV status in women. Sobti et al (2006) reported that cervical cancer risk is increased in individuals exposed to second-hand tobacco smoke with GSTM1 (null), GSTT1 (null) and GSTP1 (Ile 105 Val) genotypes, with odd ratios ranging from 6.4 to 10.2.…”

Section: (B) Cervical Intraepithelial Lesions and Neoplasiamentioning

confidence: 99%

Secondhand Tobacco Smoke

2011

Encyclopedia of Cancer

View full text Add to dashboard Cite

Interaction of passive smoking with GST (GSTM1, GSTT1, and GSTP1) genotypes in the risk of cervical cancer in India

Cited by 53 publications

References 31 publications

Glutathione S-transferase M1 and T1 polymorphisms and cervical cancer risk: A meta-analysis

Glutathione S-transferase M1 and T1 polymorphisms and cervical cancer risk: A meta-analysis

Association of Glutathione S-transferase (GSTM1, GSTT1 and GSTP1) polymorphisms and passive smoking in cervical cancer cases from North India

Secondhand Tobacco Smoke

Contact Info

Product

Resources

About