Interaction of parental KIR and fetal HLA-C genotypes with the risk of preeclampsia

H, Yu; N, Pan; Shen, Yanting; Jin, Shijie; J, Zhai; Qiao, Dongyan; Miao, Fengqin; L, Wang; Ren, Ming; Zhang, J

doi:10.3109/10641955.2014.920026

Cited by 8 publications

(8 citation statements)

References 17 publications

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“…Furthermore, this finding shows consistency with earlier research works in other populations [66,67]. It is believed that activating KIR2DS1 refers to a protective determinant, and insufficient activation of uNK cells is expected to lead to decreased invasion of trophoblasts, thereby resulting in PE [70]. Moreover, it was also indicated that if the fetus possessed more numbers of HLA-C2 genes as compared with the mother, the maternal KIR AA genotype was correlated with a higher risk for PE [70].…”

Section: The Roles Of Kir and Hla-c In Immunity Normal Pregnancy Ansupporting

confidence: 90%

“…In the context of China, women having PE have an evidently larger frequency of KIR AA genotype, primarily containing the inhibitory receptors, in addition to the lower frequency of maternal activating gene KIR2DS1 as compared with normal pregnancies [70]. Furthermore, this finding shows consistency with earlier research works in other populations [66,67].…”

Section: The Roles Of Kir and Hla-c In Immunity Normal Pregnancy Ansupporting

confidence: 88%

“…It is believed that activating KIR2DS1 refers to a protective determinant, and insufficient activation of uNK cells is expected to lead to decreased invasion of trophoblasts, thereby resulting in PE [70]. Moreover, it was also indicated that if the fetus possessed more numbers of HLA-C2 genes as compared with the mother, the maternal KIR AA genotype was correlated with a higher risk for PE [70]. This research work also supports the hypothesis that immune factors from fathers contribute to the development of PE [71].…”

Section: The Roles Of Kir and Hla-c In Immunity Normal Pregnancy Anmentioning

confidence: 99%

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The Roles of Uterine Natural Killer (NK) Cells and KIR/HLA-C Combination in the Development of Preeclampsia: A Systematic Review

Yang

Yuan

et al. 2020

BioMed Research International

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Preeclampsia (PE) is termed as a systemic disease that involves multiple organs; however, the exact etiology is still quite unclear. It is believed that the poor remodeling of uterine spiral arteries triggers PE, thereby causing failed placentation and producing inflammatory factors. The decline of blood flow results in lowering the nutrients and oxygen received by the fetus and augmenting the placental pressure in PE. Decidual immune cells, especially uterine natural killer (uNK) cells, are involved in the process of placentation. Decidual NK (dNK) cells significantly contribute to the vascular remodeling through the secretion of cytokines and angiogenic mediators in normal placental development. The abnormal activation of NK cells in both the peripheral blood and the decidua was counted among the causes leading to PE. The correlation existing between maternal killer cell immunoglobulin-like receptor (KIR) and HLA-C in trophoblast cells constitutes a robust evidence for the genetic etiology of PE. The combinations of the two kinds of gene systems, together with the KIR genotype in the mother and the HLA-C group in her fetus, are likely to exactly decide the pregnancy outcome. The women, who have the inappropriate match of KIR/HLA-C, are likely to be prone to the augmented risk of PE. However, the combinations of KIR/HLA-C in PE undergo ethnic changes. The extensive prospective research works in Europe, Asia, and Africa are required for providing more findings in PE patients.

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Section: The Roles Of Kir and Hla-c In Immunity Normal Pregnancy Ansupporting

confidence: 90%

Section: The Roles Of Kir and Hla-c In Immunity Normal Pregnancy Ansupporting

confidence: 88%

Section: The Roles Of Kir and Hla-c In Immunity Normal Pregnancy Anmentioning

confidence: 99%

See 1 more Smart Citation

The Roles of Uterine Natural Killer (NK) Cells and KIR/HLA-C Combination in the Development of Preeclampsia: A Systematic Review

Yang

Yuan

et al. 2020

BioMed Research International

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“…The authors found that the mothers lacking activating KIRs were more at risk of preeclampsia (27). Yu et al found that in Han Chinese, mothers with KIR A haplotype (AA genotype) (the haplotype consisting inhibitory KIRs) were more at risk of preeclampsia (28). Another study on Han Chinese showed that lack of activating KIRs is associated with preeclampsia (29), a condition occurring in AA patients.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Maternal KIR and Parental HLA-C Genes Diversity With Risk of Preeclampsia in Lorestan Province of Iran

Akbari¹,

Ahmadi²,

Shahsavar³

et al. 2018

International Journal of Women’s Health and Reproduction Scienc

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Introduction Preeclampsia is a pregnancy specific syndrome occurring in 3%-14% of all pregnancies worldwide based on recent reports (1). There are a variety of approaches to its pathogenesis. Among these approaches, immune system and its involved molecules are notable (2). The fascinating feature of immune system is that it does not normally reject the semi-allograft fetus. Two roles can be considered for immune system in implantation and pregnancy; the first one is impeding the formation of abnormal embryos, and the second one is maintenance of the fetomaternal interaction through immune tolerance signals. Natural killer-cells (NKs) are the most important cells in the immune tolerance. The NKs identify self-cells through their killer-cell immunoglobulin-like receptors (KIRs) expressed on their surface. These KIRs interact with the human leukocyte antigens (HLAs) expressed on surface of nuclear self-cells. KIR has 8 inhibitory (2DL1, 2DL2, 2DL3, 2DL4, 2DL5, 3DL1, 3DL2 and 3DL3) and 6 activating (2DS1, 2DS2, 2DS3, 2DS4, 2DS5 and 3DS1) genes. In human genome, both HLA and KIR have loci (not locus) and therefore they are inherited as haplotypes. As well, each gene of their loci can be polymorphic. Hence interactions of different KIRs with different HLAs lead to different outcomes. Therefore from an anthropological point of view, people of ethnicities have different KIR-HLA interactions (3-7). There are 2 classes of HLA, I and II, and class I can be classical or non-classical. HLA-G is a nonclassical HLA expressed on the semi-allograft embryonic cells. This HLA interacts with KIR2DL4 molecules and triggers the immune tolerance (8-13). NKs might have (or not) the marker CD16 which is a weapon for antibodydependent cell-mediated cytotoxicity (ADCC). Usually CD56 dim NKs are CD16 + ; therefor CD16 + CD56 dim NKs are called cytotoxic NKs. On the other hand, CD16-CD56 bright NKs are called immune-regulatory NKs (2, 14-16). About 90% of uterine NKs (UNKs) are immune-regulatory. Hence UNKs are not usually cytotoxic for embryo (2, 15). The fascinating point is that how the immune system is both killing and protective. In other words, this system is a bodyguard to protect the self and kill the non-self. Pregnancy is a semi-allograft transplantation. Thus there

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“…The combination of two maternal KIR A haplotypes (KIR AA) and fetal HLA-C2 has been demonstrated more common in preeclampsia by comparing 200 cases of preeclampsia patients with 201 cases with a normal pregnancy in British women (38). The preeclampsia patients from China also show a higher frequency of KIR AA (93,94). For Mexico preeclampsia patients, KIR AA is even predominated (95).…”

Section: Dnk Cells and Pathological Pregnancy Preeclampsiamentioning

confidence: 99%

Decidual Natural Killer Cells: A Good Nanny at the Maternal-Fetal Interface During Early Pregnancy

et al. 2021

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Decidual natural killer (dNK) cells are the tissue-resident and major subpopulation of NK cells at the maternal-fetal interface. It has been demonstrated that dNK cells play pivotal roles in pregnancy, including keeping maternal-fetal immune tolerance, promoting extravillous trophoblast (EVT) cell invasion, and driving uterine spiral artery remodeling. However, the molecular mechanisms haven’t been elucidated until recent years. In this review, we systemically introduce the generation, subsets, and surface or soluble molecules of dNK cells, which are critical for maintaining the functions of dNK cells. Further, new functions of dNK cells including well-controlled cytotoxicity, immunosurveillance and immunotrophism supporting via the cell-cell interaction between dNK cells and EVT cells are mainly focused. The molecular mechanisms involved in these functions are also illustrated. Moreover, pregnancy-associated diseases caused by the dNK cells abnormalities are discussed. It will be important for future investigations about the mechanism of maintenance of pregnancy and parturition and potential clinical applications of dNK cells.

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Interaction of parental KIR and fetal HLA-C genotypes with the risk of preeclampsia

Abstract: Women with KIR AA genotype and fewer C2 genes than their fetuses were at risk for preeclampsia in the Chinese Han population, supporting that maternal-fetal KIR-HLA-C interaction plays an important role in preeclampsia development.

Cited by 8 publications

References 17 publications

The Roles of Uterine Natural Killer (NK) Cells and KIR/HLA-C Combination in the Development of Preeclampsia: A Systematic Review

The Roles of Uterine Natural Killer (NK) Cells and KIR/HLA-C Combination in the Development of Preeclampsia: A Systematic Review

Correlation of Maternal KIR and Parental HLA-C Genes Diversity With Risk of Preeclampsia in Lorestan Province of Iran

Decidual Natural Killer Cells: A Good Nanny at the Maternal-Fetal Interface During Early Pregnancy

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