Interaction of Parabens with Nonionic Macromolecules

Blaug, Seymour M.; Ahsan, Sayed S.

doi:10.1002/jps.2600500516

Cited by 35 publications

(17 citation statements)

References 5 publications

(5 reference statements)

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“…This result is somewhat unexpected, but it has also been seen for parabens in Tween 80 micelles. 26. A possible explanation for this result is that because of the molecular size and lipophilicity of the molecule it will be distributed to the micellar core and only have a minor distribution to the polyoxyethylene shell of the micelle, thus resulting in a decrease in the micellar partition.…”

Section: Distribution To Micellesmentioning

confidence: 84%

Controlled drug release from gels using surfactant aggregates: I. Effect of lipophilic interactions for a series of uncharged substances

Paulsson

Edsman

2001

Journal of Pharmaceutical Sciences

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Section: Distribution To Micellesmentioning

confidence: 84%

Controlled drug release from gels using surfactant aggregates: I. Effect of lipophilic interactions for a series of uncharged substances

Paulsson

Edsman

2001

Journal of Pharmaceutical Sciences

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“…Here, the distribution of a substance in both oil and water is no more simply controlled by its partitioning between two phases, but several phases are present consisting of large molecules which can entrap chemicals with different mechanisms. Even though much effort has been made to explain these equilibria [7], the precise nature of the interactions between the permeant and the many components of these emulsions is uncertain and may influence the skin permeation Table 11). as a consequence of different factors, i.e.…”

Section: Resultsmentioning

confidence: 99%

Percutaneous absorption of parabens from cosmetic formulations

Pozzo

Pastori

1996

Intern J of Cosmetic Sci

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Synopsis Absorption through human skin of a series of six p-hydroxy-benzoates (parabens) was studied in vitro. A diffusion chamber was used, where the receiving phase was a physiological solution of albumin. Maximum fluxes and permeability constants of the parabens were measured from different vehicles representing hydrophilic and lipophilic phases, and from different types of common commercial cosmetic emulsions, each containing a known quantity of a single member of the series. Significant skin absorption was observed, depending upon the partition coefficient (log P octanol/water) of the permeant, composition and time of storage of the emulsions. Fluxes from all types of emulsions were higher for methyl paraben and decreased with the increasing lipophilic character of the preservative. Comparatively, fluxes from oil/water emulsions were higher than from water/oil emulsions. Moreover, a clear dependence of preservatives'percutaneous absorption on the time of storage was observed, the fluxes becoming constant after about three months after the time of preparation. The relationship between preservative activity and percutaneous absorption is discussed.

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“…Studies have shown that low concentrations of non-ionic surfactants enhanced the effect of the biocide, whereas higher concentrations led to various degree of inactivation [31]. Neutralizers are known to neutralize these preservatives by the formation of a complex between the macromolecule and the parabens; Blaug and Ahsan [29] reported that the binding capacity increased with the molecular weight of the parabens, and also by the solubilization of the preservatives in the surfactant's micelles [32,33]. The use of neutralizers before the inoculation of the cells into cream samples reduced the inhibitory effect of the preservatives considerably with Tween 80 yielding higher cell concentrations and its neutralizing activity lasting longer than the ones of Tween 60+ Span 80 and Tween 20.…”

Section: Discussionmentioning

confidence: 99%

Factors of detection of Bacillus cereus strains in eye cream

Yossa

Arce

Huang

et al. 2016

Intern J of Cosmetic Sci

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Bacillus cereus has been associated with clinical infections and is also the cause of post-traumatic endophthalmitis as well as endogenous eye infections, which can result in blindness. Cosmetics, although preserved, can be contaminated during manufacture or use and thus cause serious health issues. OBJECTIVE: We investigated the detection factors of Bacillus in eye cream preserved with parabens, including the non-ionic surfactants used as neutralizers such as Tween 80, a blend of Tween 60 and Span 80, Tween 20 and selective media. METHODS: Eye-cream samples were first mixed with neutralizers and individually inoculated with B. cereus strains, B. mycoides, B. subtilis or B. thuringiensis at a final concentration of 5 log CFU per g. The inoculated samples with and without neutralizers were analysed after 30 min and during 84-day storage at room temperature. Presumptive colonies of Bacillus were enumerated on the varieties of Bacillus agar by spiral-plating techniques and most probable number (MPN) method. RESULTS:The recovery counts of all Bacillus strains were between 4.10 and 4.58 log CFU per g in samples with Tween 80 and from 3.62 to 4.53 CFU per g in samples with TS after 30 min. Tween 20 was the least effective neutralizer. The challenged organisms, in samples without neutralizer, B. subtilis ATCC 15563 and B. cereus 4227A were detected at 1.83 and 1.49 log CFU per g after 30 min, respectively. CONCLUSION: This study showed that Tween 80 was the best neutralizer for reducing the antimicrobial effect of parabens. BACARA â and R&F plating media showed typical reaction of Bacillus cereus strains.R esum e Bacillus cereus a et e associ e a des infections cliniques et est egalement la cause de l'endophtalmie post-traumatique ainsi que des infections oculaires endog enes, ce qui peut entraîner la c ecit e. Des produits cosm etiques, bien que conserv es, peuventêtre contamin es lors de la fabrication ou de l'utilisation, et donc causer des probl emes de sant e graves.OBJECTIF: Nous avons etudi e les facteurs de d etection de Bacillus dans des cr emes pour les yeux conserv es avec des parabens, y compris les tensioactifs non ioniques utilis es comme agents neutralisants tels que le Tween 80, un m elange de Tween 60 et Span 80, Tween 20 et des milieux s electifs.

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Interaction of Parabens with Nonionic Macromolecules

Cited by 35 publications

References 5 publications

Controlled drug release from gels using surfactant aggregates: I. Effect of lipophilic interactions for a series of uncharged substances

Controlled drug release from gels using surfactant aggregates: I. Effect of lipophilic interactions for a series of uncharged substances

Percutaneous absorption of parabens from cosmetic formulations

Factors of detection of Bacillus cereus strains in eye cream

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