Controlled drug release from gels using surfactant aggregates: I. Effect of lipophilic interactions for a series of uncharged substances

Paulsson, Mattias; Edsman, Katarina

doi:10.1002/jps.1075

Cited by 59 publications

(42 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The composition of SLF was 8.3 g NaCl, 0.084 g CaCl 2 ⋅2H 2 O, and 1.4 g KCl in 1 L Milli-Q water. 23 At time intervals of 0.5, 1, 2, 3, 4, 5, 6, and 24 hours, 1 mL of samples were withdrawn and immediately replaced with the equal volume of a fresh SLF solution. Withdrawn samples were then centrifuged and CsA contents were analyzed by the HPLC assay.…”

Section: In Vitro Release Study Of Csa From Csa-containing Proliposomesmentioning

confidence: 99%

Preparation and evaluation of cyclosporin A-containing proliposomes: a comparison of the supercritical antisolvent process with the conventional film method

Karn¹,

Jin²,

Lee³

et al. 2014

IJN

View full text Add to dashboard Cite

Objectives The objectives of this study were to prepare cyclosporin A (CsA)-containing proliposomes using the supercritical antisolvent (SAS) process and the conventional thin film method for the comparative study of proliposomal formulations and to evaluate the physicochemical properties of these proliposomes. Methods CsA-containing proliposomes were prepared by the SAS process and the conventional film method, composed of natural and synthetic phospholipids. We investigated particle size, polydispersity index, and zeta potential of CsA-containing proliposomes. In addition, both production yield and entrapment efficiency of CsA in different proliposomes were analyzed. Physicochemical properties of CsA-containing proliposomes were also evaluated, using differential scanning calorimetry and X-ray diffraction. The morphology and size of CsA-containing proliposomes were confirmed, using scanning electron microscopy. We checked the in vitro release of CsA from CsA-containing proliposomes prepared by different preparation methods, comparing them with Restasis ® as a positive control and the stability of SAS-mediated proliposomes was also studied. Results CsA-containing proliposomes formed by the SAS process had a relatively smaller particle size, with a narrow size distribution and spherical particles compared with those of conventionally prepared proliposomes. The yield and entrapment efficiency of CsA in all proliposomes varied from 85% to 92% and from 86% to 89%, respectively. Differential scanning calorimetry and X-ray diffraction studies revealed that the anhydrous lactose powder used in this formulation retained its crystalline form and that CsA was present in an amorphous form. Proliposome powders were rapidly converted to liposomes on contact with water. The in vitro release study of proliposomal formulations demonstrated a similar pattern to Restasis ® . The SAS-mediated CsA-containing proliposomes were stable on storage, with no significant changes in particle size, polydispersity index, and entrapment efficiency. Conclusion These results show promising features of CsA-containing proliposomal formulations, using the SAS process for the large-scale industrial application.

show abstract

Section: In Vitro Release Study Of Csa From Csa-containing Proliposomesmentioning

confidence: 99%

Preparation and evaluation of cyclosporin A-containing proliposomes: a comparison of the supercritical antisolvent process with the conventional film method

Karn¹,

Jin²,

Lee³

et al. 2014

IJN

View full text Add to dashboard Cite

show abstract

“…They are often used as additives in pharmaceutical and dermatological preparations, cleansers, soaps and shampoos, due to their surface and interface properties (1).…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Potential Skin Irritation of Lysine-Derivative Anionic Surfactants Using Mouse Fibroblasts and Human Keratinocytes as An Alternative to Animal Testing

et al. 2004

View full text Add to dashboard Cite

Purpose. The aim of this study was to identify new surfactants with low skin irritant properties for use in pharmaceutical and cosmetic formulations, employing cell culture as an alternative method to in vivo testing. In addition, we sought to establish whether potential cytotoxic properties were related to the size of the counterions bound to the surfactants.Methods. Cytotoxicity was assessed in the mouse fibroblast cell line 3T6, and the human keratinocyte cell line NCTC 2544, using the MTT assay and uptake of the vital dye neutral red 24 h after dosing (NRU).Results. Lysine-derivative surfactants showed higher IC 50 s than did commercial anionic irritant compounds such as sodium dodecyl sulphate, proving to be no more harmful than amphoteric betaines. The aggressiveness of the surfactants depended upon the size of their constituent counterions: surfactants associated with lighter counterions showed a proportionally higher aggressivity than those with heavier ones.Conclusions Synthetic lysine-derivative anionic surfactants are less irritant than commercial surfactants such as sodium dodecyl sulphate and Hexadecyltrimethylammonium bromide and are similar to Betaines. These surfactants may offer promising applications in pharmaceutical and cosmetic preparations, representing a potential alternative to commercial anionic surfactants as a result of their low irritancy potential.

show abstract

“…When chemical substances are converted into gel form, their drug release rates are much slower than when they are in solution form. [27][28] Therefore, their efficiency periods could be much longer.…”

mentioning

confidence: 99%

Reversal of Compromised Bonding in Bleached Enamel Using Antioxidant Gel

Kaya¹,

Türkün²,

Arici³

2008

Operative Dentistry

View full text Add to dashboard Cite

Dental bond strength is significantly reduced when bonding is performed immediately after bleaching treatments. It has also been reported that the application of an antioxidant after bleaching treatment improves the adhesive bond strength of oxidized enamel tissue. The application of an antioxidant in gel form by the patient makes the application process easier and shortens time spent in the clinic. SUMMARYMany studies have shown a considerable reduction in the enamel bond strength of resin composite restorations when the bonding procedure is carried out immediately after bleaching. These studies claim that a certain waiting period is needed prior to performing the restoration in order to attain the original bond strength values. This study determined the most effective time duration for the application of sodium ascorbate prepared in gel form. The labial surfaces of 70 bovine incisors were polished with 600-grit silicon carbide paper on a water-irrigated metallurgical polishing wheel. The specimens were randomly divided into seven groups: 1) bleaching (10% Rembrandt Xtra-Comfort +) immersed in artificial saliva for seven days, 2) bonded immediately after bleaching, 3) bleaching + 10% sodium ascorbate (SA) gel for 10 minutes, 4) bleaching + 10% SA gel for 60 minutes, 5) bleaching + 10% SA gel for 120 minutes, 6) bleaching + 10% SA gel for 240 minutes and 7) bleaching + 10% SA gel for 480 minutes. After preparation, a standardshaped resin composite was applied to all specimens. The teeth were stored in distilled water at 37˚C for 24 hours and a universal testing machine determined their shear bond strength. The data were evaluated using ANOVA and Tukey tests. Antioxidant gel proved to be effective for increasing the shear bond strength of the resin composite to enamel. For maximum effectiveness, antioxidant gel should be applied to enamel for

show abstract

Controlled drug release from gels using surfactant aggregates: I. Effect of lipophilic interactions for a series of uncharged substances

Cited by 59 publications

References 28 publications

Preparation and evaluation of cyclosporin A-containing proliposomes: a comparison of the supercritical antisolvent process with the conventional film method

Preparation and evaluation of cyclosporin A-containing proliposomes: a comparison of the supercritical antisolvent process with the conventional film method

Assessment of the Potential Skin Irritation of Lysine-Derivative Anionic Surfactants Using Mouse Fibroblasts and Human Keratinocytes as An Alternative to Animal Testing

Reversal of Compromised Bonding in Bleached Enamel Using Antioxidant Gel

Contact Info

Product

Resources

About

Controlled drug release from gels using surfactant aggregates: I. Effect of lipophilic interactions for a series of uncharged substances

Cited by 59 publications

References 28 publications

Preparation and evaluation of cyclosporin A-containing proliposomes: a comparison of&nbsp;the supercritical antisolvent process with the conventional film method

Preparation and evaluation of cyclosporin A-containing proliposomes: a comparison of&nbsp;the supercritical antisolvent process with the conventional film method

Assessment of the Potential Skin Irritation of Lysine-Derivative Anionic Surfactants Using Mouse Fibroblasts and Human Keratinocytes as An Alternative to Animal Testing

Reversal of Compromised Bonding in Bleached Enamel Using Antioxidant Gel

Contact Info

Product

Resources

About

Preparation and evaluation of cyclosporin A-containing proliposomes: a comparison of the supercritical antisolvent process with the conventional film method

Preparation and evaluation of cyclosporin A-containing proliposomes: a comparison of the supercritical antisolvent process with the conventional film method