Interaction of humic acid salts with drug preparations

Khil’ko, S. L.; Semenova, R. G.

doi:10.3103/s0361521916060057

Cited by 6 publications

(7 citation statements)

References 8 publications

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“…Experimental data from the studies of Khil'ko and Semenova indicates interactions between humic acid salts and the drug preparations from papaverine hydrochloride, benzohexonium and B-group vitamins. Drug interaction with natural macromolecule mainly depends on the charges and peculiarities of molecular structure [62].…”

Section: Humic Substances In the Drug Delivery Systemmentioning

confidence: 99%

Humic Substances as a Potent Biomaterials for Therapeutic and Drug Delivery System-a Review

Jacob

Chandramohanakumar

2019

Int J App Pharm

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Efficiency of therapeutic compounds could be enhanced by encapsulation and covalent attachments to a biomaterial carrier. Complex formation with humic substances is valuable techniques to improve bioactivity of natural products. Fractal structures of humic substances also have adjacent carboxyl and hydroxyl groups. Along with molecular bonding property, reduction-oxidation and association-dissociation capacities of humic substances are considered this as a biomaterial for transform, other molecules, and substances. Immune system responses of humic acid stimulates in the human body. However, pharmaceutical importance of humic substances, demands on evidenced efficacy and a clearly defined chemical composition of the preparations used. Toxicological safety standards also have to be evaluated. This review summarises the application of humic substances as pharmaceuticaly important biomaterial. Research on this zone opened up an application for humic substances in pharmacogonasy.

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Section: Humic Substances In the Drug Delivery Systemmentioning

confidence: 99%

Humic Substances as a Potent Biomaterials for Therapeutic and Drug Delivery System-a Review

Jacob

Chandramohanakumar

2019

Int J App Pharm

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“…Humic substances as important constituent of soil organic matter can form complexes with drugs of different strengths therefore strongly bond, ion exchangeable and extractable fractions of complexes co-exist in nature [5,13,14]. The binding character varies between electrostatic interactions, hydrogen bonds and hydrophobic interactions [5,[13][14][15][16][17][18]. Sulfonamides are one of the most commonly used antibiotic in human and veterinary medicine.…”

Section: Introductionmentioning

confidence: 99%

Transport and interactions of sulfapyridine in agarose hydrogels enriched by humic acids

Klučáková

2021

NANOCON 2021 Conference Proeedings

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Knowledge of behaviour of pharmaceuticals as contaminants in nature is essential for their mobility and toxicity in the soils and surface-and ground-water environments. Their migration ability and toxicity can be affected by their interactions with organic matter. In this contribution, sulfapyridine (a sulfanilamide drug used for antibacterial medication) is studied from the point of view of its transport in hydrogels containing humic substances. Agarose hydrogel was used as a model medium for the transport experiments. Standard Elliot soil humic acid (4S102H) purchased from International Humic Substances Society was incorporated into the hydrogel as an active nanomaterial for interactions with drug and potential suppression of their migration and toxicity in soil systems. The method of diffusion couple was applied on the diffusion experiments. Donor part was saturated by sulfapyridine and acceptor part was free of drug. After connecting of both parts, the time development of concentration profiles in the couple was monitored. The effective diffusion coefficients for the transport of sulfapyridine in hydrogel enriched by humic acids and pure agarose hydrogel were determined and compared. It was found that the transport of drug is influenced by interactions with humic acids which can immobilize partially sulfapyridine in humic structure. Simultaneously, sorption/desorption experiments were realized. Their results confirmed high degree of drug immobilization (60 -90 % in the dependence on drug concentration).

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“…These groups are responsible for exhibiting good hemostasis, and antidiarrheal functions. Humic acid is widely used in medicine and feed additives [ 24 – 26 ], and the phenolic-hydroxyl and carboxyl-groups contents in humic acid is positively correlated with its biological activity [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

An acidic-groups detection method and its application to analysis of Chinese humic acid samples

Peng-fei

Wang

et al. 2020

PLoS ONE

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The method of non-aqueous conductivity titration (NACT) of organic weak acids was applied to quickly and accurately determine the phenolic-hydroxyl and carboxyl-groups contents in humic acid. By varying the pH of the humic-acid sample, the concentration of the titrant, and the nitrogen-gas flow rate, the optimal titration conditions were determined to be a sample pH of 4, titrant concentration of 0.05 mol/L, and nitrogen-gas flow rate of 80 mL/min. Applying the detection method to p-hydroxybenzoic acid showed that its phenolic-hydroxyl content was 758.82±111.76 cmol/kg and carboxyl content was 744.44±51.11 cmol/kg. The theoretical phenolic-hydroxyl and carboxyl-groups contents of the p-hydroxybenzoic acid were 723.96 cmol/kg respectively, indicating that the method can accurately quantify the carboxyl and phenolic-hydroxyl groups in the sample. The NACT was used to measure the phenolic-hydroxyl and carboxyl-groups contents in humic acid quickly and accurately. In addition, 29 humic acid samples from 8 provinces of China covering the main humic-acid producing areas were collected and analyzed for acidic-groups content using the reported method.

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Interaction of humic acid salts with drug preparations

Cited by 6 publications

References 8 publications

Humic Substances as a Potent Biomaterials for Therapeutic and Drug Delivery System-a Review

Humic Substances as a Potent Biomaterials for Therapeutic and Drug Delivery System-a Review

Transport and interactions of sulfapyridine in agarose hydrogels enriched by humic acids

An acidic-groups detection method and its application to analysis of Chinese humic acid samples

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