Humic Substances as a Potent Biomaterials for Therapeutic and Drug Delivery System-a Review

Jacob, Kala K; Kj, Prashob Peter; Chandramohanakumar, N.

doi:10.22159/ijap.2019v11i3.31421

Cited by 24 publications

(20 citation statements)

References 35 publications

(41 reference statements)

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“…The presence of phenolic and other redox-active functional groups in HS accounts for their capability of reducing toxic impacts of organic and inorganic oxidizers [ 9 , 10 , 11 ], similar to the redox activity of other natural phenolic compounds [ 12 , 13 ]. The biological activity of HS is intensively discussed now [ 14 , 15 , 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Humic Substances Mitigate the Impact of Tritium on Luminous Marine Bacteria. Involvement of Reactive Oxygen Species

Rozhko

Kolesnik

Badun

et al. 2020

IJMS

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The paper studies the combined effects of beta-emitting radionuclide tritium and Humic Substances (HS) on the marine unicellular microorganism—luminous bacteria—under conditions of low-dose radiation exposures (<0.04 Gy). Tritium was used as a component of tritiated water. Bacterial luminescence intensity was considered as a tested physiological parameter. The bioluminescence response of the marine bacteria to tritium corresponded to the “hormesis” model: it included stages of bioluminescence inhibition and activation, as well as the absence of the effect. HS were shown to decrease the inhibition and activation effects of tritium, similar to those of americium-241, alpha-emitting radionuclide, studied earlier. Correlations between the bioluminescence intensity and the content of Reactive Oxygen Species (ROS) were found in the radioactive bacterial suspensions. The results demonstrate an important role of HS in natural processes in the regions of low radioactive contamination: HS can mitigate radiotoxic effects and adaptive response of microorganisms to low-dose radioactive exposures. The involvement of ROS in these processes was demonstrated.

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Section: Introductionmentioning

confidence: 99%

Humic Substances Mitigate the Impact of Tritium on Luminous Marine Bacteria. Involvement of Reactive Oxygen Species

Rozhko

Kolesnik

Badun

et al. 2020

IJMS

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“…A complex formation with HSs is used in drug delivery systems as a carrier agent to increase the bioactivity of natural products. Complexes with HAs improve the solubility of a given factor, thus increasing its effectiveness (Kala, Prashob and Chandramohanakumar, 2019;Khan, Jain, Aqil, Agarwal, Mirza and Iqbal, 2020). For example, the inclusion of complexes with FA extracted from peat positively influence the solubility of ketoconazole, similar results have been obtained for an FA and aspirin formulation, which helps to overcome the problem of the stability and bioavailability of aspirin.…”

Section: Introductionmentioning

confidence: 70%

Humic substances and significance of their application – a review

Kłeczek

Anielak

2021

Technical Transactions

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This paper is based on recent articles regarding applications of humic substances (HSs). HSs are natural organic materials, which have a number of potential applications. Furthermore, HSs are cheap, widespread and obtainable from bio-waste materials. HSs can be used as organic compound sorbents or in detoxification. They are applied as organic additives due to their positive effect on soil and plants, even under stress conditions. HSs reduce water consumption and minimise environmental problems. HSs are utilised for the remediation of multi-metal contaminated soils and as substitutes for synthetic washing agents. From an environmental engineering point of view, it is beneficial to remove HSs from municipal management, where they are undesirable (by-products of disinfection) and to utilise them where they are valuable. The aim of this article is to provide a greater insight into research about the applications of HSs.

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“…The cytotoxic effect of humic acid on adenocarcinoma has also been reported (40). Humic acid induces the release of plasminogen activators and converts plasminogen into plasmin, which degrades insoluble fibrin to soluble fibrinogen degradation product (41).…”

Section: Nutraceutical Applications Of Humic Substancesmentioning

confidence: 85%

COVID-19 prevention and management: Potential applications of humic substances

Koul¹,

Khosla²,

Manhas³

et al. 2021

IMCR

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Background: COVID-19 pandemic has forced the human population to rethink over the lifestyle and food habits being followed by them. During the current scenario, when cases of more virulent new strain are emerging and specific treatment are still underway, we must look back to the Darvin’s theory of “Survival of the fittest” and in order to sustain the pandemic, we must follow the rule “Prevention is better than cure”. Traditional Medicinal System can bring possible solution including prevention and control of COVID-19. Humic substances have been used for antiviral activities, signifying that it has potential applications in the management and prevention of infectious diseases. Summary: Present article is focused on the assessment of the naturally occurring humic substances, which are major constituents of Shilajit, being used in traditional system of medicine and can be used against for the prevention of COVID-19. Key message: Humic substances not only improve the immune system, but also have anti-inflammatory, antioxidant and antiviral activities against human RNA viruses. Therefore, while the entire world is preparing to deal with alarming threat of community spread of COVID-19, Humic substances may play a vital role in improving the innate immunity for prevention and management of SARS-CoV-2 infection

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Humic Substances as a Potent Biomaterials for Therapeutic and Drug Delivery System-a Review

Cited by 24 publications

References 35 publications

Humic Substances Mitigate the Impact of Tritium on Luminous Marine Bacteria. Involvement of Reactive Oxygen Species

Humic Substances Mitigate the Impact of Tritium on Luminous Marine Bacteria. Involvement of Reactive Oxygen Species

Humic substances and significance of their application – a review

COVID-19 prevention and management: Potential applications of humic substances

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