Interaction of Estrogen and Progesterone in Chick Oviduct Development

Palmiter, Richard D.; Wrenn, Joan T.

doi:10.1083/jcb.50.3.598

Cited by 189 publications

(94 citation statements)

References 30 publications

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“…The chick oviduct presents a useful model for studying the interactions between progesterone and oestrogen at the molecular level since considerable literature has accumulated, documenting the differential effects of these hormones on oviduct growth, cytodifferentiation and egg white protein synthesis. In the immature chick oviduct, progesterone antagonizes the oestrogen-induced tissue growth and differentiation of tubular gland cells [5,28]. The situation is appreciably different in oestrogenpretreated and then withdrawn chickens where subsequent treatments with oestrogen and/or progesterone are capable, each in their own specific way [9,30], of independently inducing ovalbumin synthesis, in preexisting tubular gland cells.…”

Section: Discussionmentioning

confidence: 99%

Steroid Receptors and Effects of Oestradiol and Progesterone on Chick Oviduct Proteins

Sutherland

Geynet

Binart

et al. 1980

European Journal of Biochemistry

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After a single injection of oestradiol benzoate (1.5 mg/kg) to oestrogen-withdrawn chickens, there was an increase in magnum wet weight, DNA polymerase a activity, adenosine-3', 5'-monophosphate-dependent protein-kinase activity and estrogen-receptor concentration, as measured over 36 h. Besides these intracellular proteins, the secretory proteins ovalbumin and conalbumin were also augmented, and detailed time-course studies were performed.Early induction kinetics for ovalbumin and conalbumin synthesis, which differed for each protein, were independent of the dose of oestradiol benzoate injected if it exceeded 0.1 mg/kg. After 6 h for ovalbumin and 2 h for conalbumin, the induction curves diverged according to the dose of hormone administered and in correlation with the persistence of elevated nuclear oestrogenreceptor concentrations, a result confirmed with 11 P-methoxy-l7a-ethynyloestradiol (R 2858), a powerful synthetic oestrogen.When oestradiol benzoate (1 mg/kg) and progesterone (3 mg/kg) were injected simultaneously, the rate of conalbumin synthesis, during the first 6 -8 h, was lower than that observed in animals injected with oestradiol benzoate alone. However at later times conalbumin synthesis was greater in animals receiving both hormones than with oestradiol alone. In contrast, the rate of ovalbumin synthesis after the combined injection was higher than that induced by either hormone alone throughout the entire experimental period.In order to study further the synergistic and antagonistic activities of these two hormones, a single injection of progesterone (3 mg/kg) was administered 6, 12 or 18 h after 1.5 mg/kg oestradiol benzoate. Progesterone administration resulted in a reduction in cytoplasmic, nuclear and total oestrogen receptor concentration for at least 6 h when compared with the values in birds treated with oestrogen alone. DNA polymerase and protein kinase activities were also reduced during this period. Subsequently, all parameters increased, and by 18 -24 h after progesterone treatment, reached values higher than those observed in animals receiving oestrogen alone.Both cytoplasmic and nuclear forms of the oestrogen receptor have been described in the chick oviduct [I -41, an oestrogen-responsive tissue. In the oestrogen-withdrawn chicken [5] where levels of endogenous oestrogen are low, the oestrogen receptor is found predominantly in the cytosoluble fraction of oviduct cells [4]. During the first hour after a single secondary injection of oestradiol, the cytosoluble receptor falls and this is accompanied by a comparable increase in the concentration of receptor in the nuclear compartment [4] as in other oestrogen target tissues (review in [6]). One hour after an injection of oestradiol or oestradiol benzoate within the range of 0.1 -1 mg/kg, the same amount of oestradiol-receptor complex is phosphate ~ Ahhrrviution Cyclic AMP or CAMP, adenosine 3',5'-monofound in the nucleus, while during the following hours the concentration of the nuclear receptor is dosedependent [4].Current theories...

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Section: Discussionmentioning

confidence: 99%

Steroid Receptors and Effects of Oestradiol and Progesterone on Chick Oviduct Proteins

Sutherland

Geynet

Binart

et al. 1980

European Journal of Biochemistry

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“…Le contr61e hormonal de la diffErenciation du magnum des oiseaux est plus complexe que ne le laissaient prEvoir les schemas de Oka et Schimke (11) et Palmiter et Wrenn (12). Les r61es physiologiques des oestrog~nes notamment doivent ~tre reconsid6r6s.…”

Section: Discussionunclassified

“…I1 est connu que la progest6rone inhibe les divisions et stimule fortement les ph6no-m~nes s6cr6toires du magnum des oiseaux lorsqu'elle agit avec ou apr~s les cestrog~nes (10)(11)(12)8). Notre 6tude montre par ailleurs, l'importance fondamentale de la dose de benzoate d'0estradiol dans les traitements ~stro-progestatifs puisque avec 10 p,g/jour d'~estrog6ne, la progest6rone permet en 6 jours la mise en place d'un 6pith61ium comparable h celui d'une caille en ponte alors qu'en doublant la dose d'oestrog~ne, toutes les cellules de l'6pith61ium luminal deviennent s6cr6trices.…”

Section: Discussionunclassified

[Ciliogenesis in the mucous cells of the quail oviduct. II. Hormonal control]

Sandoz¹,

Biosvieux-Ulrich²,

Laugier³

et al. 1976

The Journal of Cell Biology

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The hormonal control of ciliogenesis and transformation of mucous cells was studied in the oviduct (magnum) of ovariectomized quails. Estradiol benzoate induces ciliogenesis with doses varying from 10 t~g/day to 100 txg/day after 6 days of treatment. With 100 txg/day, differentiation of some mucous cells is also induced as well as the formation of transitory "mixed cells" which are in the process of ciliogenesis and contain mucous granules.Associated with progesterone (1 mg/day), estradiol benzoate (10 txg/day) induces the differentiation of mucous cells and ciliated cells. The luminal epithelium of quails injected with this mixture is similar to the luminal epithelium observed in the oviduct of laying quails. With the same dose of progesterone (1 mg/day) and 20 ~g/day of estradiol benzoate for 6 days, ciliogenesis is completely inhibited. All epithelial cells are secretory cells.Transformation of 50% of the mucous cells into ciliated cells is obtained by following the previous estradiol-progesterone treatment with the injection of estradiol benzoate (20 /zg/day) for 3 days. Divisions of mucous cells were also observed. It is also possible to induce ciliogenesis in some mucous cells by withdrawing both hormones for 3 days. In this case, no cell divisions were observed.La ciliogen~se s'effectue spontan6ment dans les cellules ~ mucus de l'6pith61ium du magnum des cailles en ponte (article I), mais ce ph6nom~ne n'int6resse qu'une faible proportion des cellules. Dans le but de d6montrer la transformation de cellule h mucus en cellule cili6e, nous avons cherch6 ~ reproduire et ~ g6n6raliser ces transformations par des traitements hormonaux chez des cailles castr6es.Bien que le magnum des oiseaux soit un organe cible des hormones st6roides particuli~rement 6tu-di6, le contr61e hormonal de la ciliogen~se n'a pas 6t6 jusqu'ici clairement d6montr6. Aussi, avant de provoquer la transformation des cellules h mucus en cellules cili6es, nous avons cherch6 h contr61er, chez des cailles ovariectomis6es, la diff6renciation des cellules ~pith61iales soit en cellules cili6es, soit en cellules h mucus. La dose d'oestrog~ne inject6e 460

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“…In chickens, ovalbumin (OVA), the major constituent of egg white, is synthesized in the oviduct under estrogenic induction (Kohler et al, 1969;Palmiter and Wrenn, 1971), and its 5'-flanking region contains a corresponding DNA recognition sequence (AGGTGA) that is recognized by the ERα and ERβ P-box (CEGCKA) (Glass, 1994). Thus, we deduced that ERs have a certain function in the expression of OVA mRNA, although the role that ERs play in the expression of OVA in POECs is unknown.…”

Section: Introductionmentioning

confidence: 99%

Molecular cloning, expression, and regulation of estrogen receptors in pigeon oviduct epithelial cells

Zhang¹,

Chen²,

Li³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Estrogen regulates reproductive behavior and drives the proliferation and differentiation of several cell types. These physiological functions of estrogen are mediated by estrogen receptors (ERs), and each ER isoform plays a distinct role. To clarify the molecular mechanism of estrogen action and to evaluate the effect of ERs on the secretion of ovalbumin (OVA) in pigeon oviduct epithelial cells (POECs), we determined the complete coding sequences encoding ER alpha (ERα) and ER beta (ERβ) in pigeons. The abundance of pigeon ERα and ERβ mRNA was detected using quantitative polymerase chain reaction. These results revealed that pigeon ERα is highly expressed in the oviduct, while pigeon ERb is highly expressed in the ovary and kidney. We hypothesize that ERα mRNA predominates over that of ERβ in the oviduct. The expression of ERα can be down- 1927©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 13 (1): 1926-1937 (2014 Characterization and regulation of pigeon ERs regulated by 17β-estradiol, and the knockdown of ERα promoted OVA mRNA expression in cultured POECs, indicating that ERα may play an important role in OVA secretion.

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Interaction of Estrogen and Progesterone in Chick Oviduct Development

Cited by 189 publications

References 30 publications

Steroid Receptors and Effects of Oestradiol and Progesterone on Chick Oviduct Proteins

Steroid Receptors and Effects of Oestradiol and Progesterone on Chick Oviduct Proteins

[Ciliogenesis in the mucous cells of the quail oviduct. II. Hormonal control]

Molecular cloning, expression, and regulation of estrogen receptors in pigeon oviduct epithelial cells

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