Interaction of drugs with microcrystalline cellulose at the molecular and supermolecular levels

Burkhanova, N. D.; Yugai, S. M.; Халиков, С. С.; Turganov, M. M.; Muratova, S. A.; Nikonovich, G. V.; Aripov, Kh. N.

doi:10.1007/bf02234892

Cited by 7 publications

(7 citation statements)

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“…For this purpose, nanocomposites grafted with Phos were subjected to a time delay of 12, 18 and 24 h at 37 1C before bacteria inoculation. 34 Our results showed that in spite of strong binding by intermolecular interactions between these components, the released drug retains its medicinal properties against pathogen microorganism and confirmed that the drug molecule and the nanocomposite are compatible with each other. Nanocomposites grafted with Phos in concentration of 10Â MIC reduced bacterial growth compared to control without cellulose nanofibers (data not shown), but did not result in a complete growth inhibition.…”

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confidence: 67%

Antibacterial and photochemical properties of cellulose nanofiber–titania nanocomposites loaded with two different types of antibiotic medicines

et al. 2015

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Nanocomposite dermal drug delivery systems based on cellulose nanofibers with grafted titania nanoparticles loaded by two antibiotic medicines from different classes, i.e. tetracycline (TC) and phosphomycin (Phos), were successfully produced by a ''green chemistry'' approach in aqueous media. The influence of a different surface binding mechanism between the drug molecule and modified cellulose nanofibers on the release of the drug and, as a result, on antimicrobial properties against common pathogens Gram-positive, Staphylococcus aureus and Gram-negative Escherichia coli was investigated. The disk diffusion method and broth culture tests using varying concentrations of drugs loaded to nanocomposites were carried out to investigate the antibacterial effects. The influence of UV irradiation on the stability of the obtained nanocomposites and their antibacterial properties after irradiation were also investigated, showing enhanced stability especially for the TC loaded materials. These findings suggest that the obtained nanocomposites are promising materials for the development of potentially useful antimicrobial patches.

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confidence: 67%

Antibacterial and photochemical properties of cellulose nanofiber–titania nanocomposites loaded with two different types of antibiotic medicines

et al. 2015

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“…Consequently, drug molecule and nanocomposite are compatible with each other. It is important to mention that strong chemical interaction between these components may lead to complete loss of medical properties of drugs 45 . At the same time, there is possibility of intermolecular interactions since the drug molecule contains various functional groups.…”

Section: Preparation and Characterization Of Nanocomposite Tio 2 mentioning

confidence: 99%

Cellulose nanofiber–titania nanocomposites as potential drug delivery systems for dermal applications

et al. 2015

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“…The formation of similar inclusion complexes was confirmed on the basis of the IR spectra of SD carbendazim (synonym:medamine), ABZ, fenbendazole (FBZ), and triclabendazole (TCB) with PVP and Arabinogalactan (AG) [35]. Under similar conditions, the medamine substance was subjected to joint mechanical treatment with Microcrystalline cellulose (MCC) [41,42], with plant proanthocyanidines [43], and the corresponding SD were obtained, which had increased solubility in water, better permeability through model semipermeable membranes, and, hence, increased bioavailability.…”

Section: Solid Dispersions Of Anthelmintics For Animal Healthmentioning

confidence: 88%

Solid Dispersions of Anthelmintics and Plant Protection Preparations

Халиков

2021

Solids

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Because of the rapid development of nanotechnologies, materials, in particular, solid dispersions (SDs), which are actively introduced into the life of modern man, have been obtained. Special progress in this area is observed in industry and medicine. The use of SDs in agriculture is lagging far behind, despite the growing number of scientific papers on this topic. At the same time, the prospects for the introduction of SDs in the agro-industrial complex are obvious. The review presents the results of research on the development of innovative preparations based on SD to protect plants from diseases and pests of cultivated plants, as well as parasiticides to protect animal health based on modern achievements of nanotechnology. One of these technologies is the methods of mechanochemistry, which improve the properties of poorly soluble biologically active substances by their joint mechanical treatment with water-soluble polymers and auxiliary substances.

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Interaction of drugs with microcrystalline cellulose at the molecular and supermolecular levels

Cited by 7 publications

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Antibacterial and photochemical properties of cellulose nanofiber–titania nanocomposites loaded with two different types of antibiotic medicines

Antibacterial and photochemical properties of cellulose nanofiber–titania nanocomposites loaded with two different types of antibiotic medicines

Cellulose nanofiber–titania nanocomposites as potential drug delivery systems for dermal applications

Solid Dispersions of Anthelmintics and Plant Protection Preparations

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