Interaction of curcumin with Al(III) and its complex structures based on experiments and theoretical calculations

Jiang, Teng; Wang, Long; Zhang, Sui; Sun, Pingchuan; Ding, Chuan‐Fan; Chu, Yanqiu; Zhou, Ping

doi:10.1016/j.molstruc.2011.07.059

Cited by 39 publications

(35 citation statements)

References 54 publications

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“…1C) (Cotton and Wilkinson, 1980). Accordingly, curcumin forms chelates with metals such as boron (Mohri et al, 2003;Rao and Aggarwal, 2008), copper (Baum and Ng, 2004;Barik et al, 2007;Zebib et al, 2010;Addicoat et al, 2011), aluminum (Jiang et al, 2011), magnesium (Zebib et al, 2010), zinc (Zebib et al, 2010), lead (Daniel et al, 2004), cadmium (Daniel et al, 2004), and ferrous (Fe 2+ ) and ferric (Fe 3+ ) iron (Tønnesen and Greenhill, 1992;Borsari et al, 2002;Baum and Ng, 2004;Bernabe-Pineda et al, 2004b;Ak and Gulcin, 2008;Dairam et al, 2008), but also with metal oxides such as vanadyl (Thompson et al, 2004) and nonmetals such as selenium (Zebib et al, 2010). Although the majority of experimental data indicate that the metal cations bind the oxygens of the b-diketo moiety (Borsari et al, 2002;Zebib et al, 2010; (D S , bottom structure) of enolic curcumin are plotted on the axes, all connected by a color-coded single trace.…”

Section: H-bond Accepting Capacity Of the Methoxy Groupsmentioning

confidence: 99%

“…Cancer Pharmacology of Curcumin et al, 2011), some have proposed that metal chelation may also be facilitated by the valence electrons of the methoxyphenyl oxygens (Ak and Gulcin, 2008;Jiang et al, 2011) based on the negative charge of these oxygens (Fig. 1C) and the metal chelating activity of b-diketonelacking (poly)phenolics such as quercetin (Fiorucci et al, 2007) and catechol (Borsari et al, 2002).…”

Section: H-bond Accepting Capacity Of the Methoxy Groupsmentioning

confidence: 99%

See 1 more Smart Citation

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Golen²,

et al. 2013

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Section: H-bond Accepting Capacity Of the Methoxy Groupsmentioning

confidence: 99%

Section: H-bond Accepting Capacity Of the Methoxy Groupsmentioning

confidence: 99%

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Golen²,

et al. 2013

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“…In addition, prolonged Al 3+ exposure induces oxidative stress and increases the formation of Aβ peptide . Curcumin has a protective effect against Al toxicity due to its strong interaction with Al 3+ , which would limit the interaction of Al 3+ with the Aβ peptide . The strong interaction of curcumin derivatives with some other toxic metal ions, like Al 3+ , Cu 2+ , and Hg 2+ , has also been reported .…”

Section: Alzheimer's Diseasementioning

confidence: 99%

Biological properties of metal complexes of curcumin

et al. 2019

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Curcumin, a naturally occurring phenolic compound isolated from Curcuma longa, has different pharmacological effects, including antiinflammatory, antimicrobial, antioxidant, and anticancer properties. However, curcumin has been found to have a limited bioavailability because of its hydrophobic nature, low-intestinal absorption, and rapid metabolism. Therefore, there is a need for enhancing the bioavailability and its solubility in water in order to increase the pharmacological effects of this bioactive compound. One strategy is curcumin complexation with transition metals to circumvent the abovementioned problems. Curcumin can undergo chelation with various metal ions to form metallo-complexes of curcumin, which may show greater effects as compared with curcumin alone. Promising results with metal curcumin complexes have been observed with regard to antioxidant, anticancer, and antimicrobial activity, as well as in treatment of Alzheimer's disease. The present review provides a concise summary of the characterization and biological properties of curcumin-metal complexes. © 2019 BioFactors, 45(3):304-317, 2019

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“…In addition to that, it has also reduced stability towards oxidation, light, alkalinity, enzymes and heat. Therefore in order to increase its pharmacological effectiveness, the latest researches were focused on improving the bioavailability, chemical and photochemical stability of CR using different methods such as: conjugation with cyclodextrin, β-diglucoside, αS1-Casein, β-Lactoglobulin [8][9][10][11], encapsulation in nanoparticles of biocompatible polymers, exosomes, lipid nanoparticles, dextrin nanogels, dendrimers, metal oxide nanoparticles [12][13][14][15][16][17][18], complexation with multivalent metal cations [19,20].…”

Section: Introductionmentioning

confidence: 99%

Curcumin Incorporation into Zn3Al Layered Double Hydroxides—Preparation, Characterization and Curcumin Release

et al. 2020

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Curcumin (CR) is a natural antioxidant compound extracted from Curcuma longa (turmeric). Until now, researches related to the incorporation of CR into layered double hydroxides (LDHs) were focused only on hybrid structures based on a MgxAl-LDH matrix. Our studies were extended towards the incorporation of CR in another type of LDH-matrix (Zn3Al-LDH) which could have an even more prolific effect on the antioxidant activity due to the presence of Zn. Four CR-modified Zn3Al-LDH solids were synthesized, e.g., PZn3Al-CR(Aq), PZn3Al-CR(Et), RZn3Al-CR(Aq) and RZn3Al-CR(Et) (molar ratio CR/Al = 1/10, where P and R stand for the preparation method (P = precipitation, R = reconstruction), while (Aq) and (Et) indicate the type of CR solution, aqueous or ethanolic, respectively). The samples were characterized by XRD, Attenuated Total Reflectance Fourier Transformed IR (ATR-FTIR) and diffuse reflectance (DR)-UV–Vis techniques and the CR-release was investigated in buffer solutions at different pH values (1, 2, 5, 7 and 8). XRD results indicated a layered structure for PZn3Al-CR(Aq), PZn3Al-CR(Et), RZn3Al-CR(Aq) impurified with ZnO, while RZn3Al-CR(Et) contained ZnO nano-particles as the main crystalline phase. For all samples, CR-release revealed a decreasing tendency towards the pH increase, and higher values were obtained for RZn3Al-CR(Et) and PZn3Al-CR(Et) (e.g., 45% and 25%, respectively at pH 1).

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Interaction of curcumin with Al(III) and its complex structures based on experiments and theoretical calculations

Cited by 39 publications

References 54 publications

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Biological properties of metal complexes of curcumin

Curcumin Incorporation into Zn3Al Layered Double Hydroxides—Preparation, Characterization and Curcumin Release

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