Interaction of copper(II) with the non-steroidal anti-inflammatory drugs naproxen and diclofenac: Synthesis, structure, DNA- and albumin-binding

Alkyl and aryl sulfonyl p-pyridine ethanone oximes are efficient DNA photo-cleavage agents

“…The values of the Stern-Volmer constant (K SV ) as calculated from the SternVolmer plots (Insets in Fig. 6) are 6.07(± 0.18) × 10 4 M − 1 for 3 and 3.72(± 0.10) × 10 4 M − 1 for 8; they may be considered rather high and verify the tight binding of compounds 3 and 8 to DNA [29,32]. Taking τ o = 23 ns as the fluorescence lifetime of EB-DNA system [33], the quenching constants of the compounds as calculated ; the values of the k q constants are significantly higher than 10 10 M −1 s −1 suggesting, thus, the quenching via a static mechanism [34].…”

“…The slight hypochromism (2% for 3 and 3% for 8) observed in the UV spectra of the compounds in the presence of increasing amounts of CT DNA (Fig. 4) [29].…”

Nickel–quinolones interaction

“…The decrease in current can be explained in terms of an equilibrium mixture of free and DNA-bound complex to the electrode surface [70]. For increasing amounts of CT DNA, one at least of the cathodic (E pc ) or the anodic (E pa ) potentials of complexes shows a positive shift (ΔE pc = (+2) − (+56) mV) ( Table 6) suggesting an intercalative mode of binding, while for 2 the second potential shifts to more negative values and the co-existence of electrostatic interaction may not be ruled out [7,12,14,21,22,56,[70][71][72][73].…”

“…Table 6 Cathodic and anodic potentials (in mV) for the redox couple Ni(II)/Ni(I) in DMSO and in 1/2 DMSO/buffer solution of the complexes in the absence and presence of CT DNA. compounds in between the DNA base pairs, leading to an increase in the separation of base pairs at intercalation sites and, thus, an increase in overall DNA length [56,73].…”

Copper(II) complexes with antimicrobial drug flumequine: Structure and biological evaluation

“…Copper(II) complexes with diverse drugs have shown numerous biological activities such as antitumor [15,16], antioxidant [17,18], antibacterial [19][20][21] and antifungal [22]. In many cases, mixed-ligand copper(II) complexes with drugs and N-donor ligands have shown better activity than free drug; the Cu(II) with ligands the antibacterial quinolone drug N-propylnorfloxacin [15,16], the non-steroidal antiinflammatory drugs mefenamic acid, naproxen and diclofenac [17,18] or phenoxyalkanoic herbicides [23] and the N-donors 2,2′-bipyridine (bipy), 1,10-phenanthroline (phen), 2,2′-bipyridylamine (bipyam) or pyridine (py) are some representative examples of complexes with enhanced biological activity.…”