Interaction of bioactive glass with clodronate

Rosenqvist, Kirsi; Airaksinen, Sari; Fraser, Sara J.; Gordon, Keith C.; Juppo, Anne

doi:10.1016/j.ijpharm.2013.04.059

Cited by 10 publications

(7 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Barroug [22] during the association between nanocrystalline apatites and risedronate. Also this finding illustrates the interaction between bioactive glass and bisphosphonates, thus this result coincide with other studies [31]. Then, we remark the presence of C-P bands at 612 and 814 cm -1 and also the appearance of two bands of P-OH at 849 and 872 cm -1 .…”

Section: Raman Spectroscopysupporting

confidence: 92%

Risedronate adsorption on bioactive glass surface for applications as bone biomaterial

Mosbahi

Oudadesse

Lefeuvre

et al. 2016

Applied Surface Science

View full text Add to dashboard Cite

International audienceThe aim of the current work is to study the physicochemical interactions between bisphosphonates molecules, risedronate (RIS) and bioactive glass (46S6) after their association by adsorption phenomenon. To more understand the interaction processes of RIS with the 46S6 surface we have used complementary physicochemical techniques such as Infrared (FTIR), RAMAN and nuclear magnetic resonance (NMR) spectroscopy. The obtained results suggest that risedronate adsorption corresponds to an ion substitution reaction with silicon ions occurring at the bioactive glass surface. Thus, a pure bioactive glass was synthesized and fully characterized comparing the solids after adsorption (46S6-XRIS obtained after the interaction of 46S6 and X% risedronate). Therefore, based on the spectroscopic results FTIR, RMAN and MAS-NMR, it can be concluded that strong interactions have been established between RIS ions and 46S6 surface. In fact, FTIR and RAMAN spectroscopy illustrate the fixation of risedronate on the bioactive glass surface by the appearance of several bands characterizing risedrontre. The 31P MAS-NMR of the composite 46S6-XRIS show the presence of two species at a chemical shift of 15 and 19 ppm demonstrating thus the fixation of the RIS on 46S6 surface

show abstract

Section: Raman Spectroscopysupporting

confidence: 92%

Risedronate adsorption on bioactive glass surface for applications as bone biomaterial

Mosbahi

Oudadesse

Lefeuvre

et al. 2016

Applied Surface Science

View full text Add to dashboard Cite

show abstract

“…A preliminary in vivo study reported that the combination of the BP alendronate with BG led to increased bone formation on rats in comparison with the control groups [92]. A few years later, Rosenqvist et al explored the physicochemical interactions of clodronate with BG based on the hypothesis that their beneficial impact originates not only from the pharmacological properties of the drug but also from the formation of a complex between them that creates a favorable environment for ion exchange [57].…”

Section: Resultsmentioning

confidence: 99%

“…The combination of bisphosphonate (BP) drugs like alendronate and clodronate with bioglass, results in hybrid particles with a stronger capacity to regenerate bone defects than bioglass on its own [56,57]. It was also hypothesized that Sr substituted bioglass would further boost the osteogenic potential of BP-BG hybrid particles [56].…”

Section: Introductionmentioning

confidence: 99%

Composite Membranes of Poly(ε-caprolactone) with Bisphosphonate-Loaded Bioactive Glasses for Potential Bone Tissue Engineering Applications

Terzopoulou

Baciu

Gounari³

et al. 2019

Molecules

View full text Add to dashboard Cite

Poly(ε-caprolactone) (PCL) is a bioresorbable synthetic polyester with numerous biomedical applications. PCL membranes show great potential in guided tissue regeneration because they are biocompatible, occlusive and space maintaining, but lack osteoconductivity. Therefore, two different types of mesoporous bioactive glasses (SiO2-CaO-P2O5 and SiO2-SrO-P2O5) were synthesized and incorporated in PCL thin membranes by spin coating. To enhance the osteogenic effect of resulting membranes, the bioglasses were loaded with the bisphosphonate drug ibandronate prior to their incorporation in the polymeric matrix. The effect of the composition of the bioglasses as well as the presence of absorbed ibandronate on the physicochemical, cell attachment and differentiation properties of the PCL membranes was evaluated. Both fillers led to a decrease of the crystallinity of PCL, along with an increase in its hydrophilicity and a noticeable increase in its bioactivity. Bioactivity was further increased in the presence of a Sr substituted bioglass loaded with ibandronate. The membranes exhibited excellent biocompatibility upon estimation of their cytotoxicity on Wharton’s Jelly Mesenchymal Stromal Cells (WJ-SCs), while they presented higher osteogenic potential in comparison with neat PCL after WJ-SCs induced differentiation towards bone cells, which was enhanced by a possible synergistic effect of Sr and ibandronate.

show abstract

“…Recently, it has been shown that clodronate enhances the bioactivity of BAG and keeps this effect ongoing longer than what is observed for BAG alone [18]. Based on experiment done by Rosenqvist and coworkers [18], it is apparent that there is a strong interaction between BAG and clodronate resulting in an enhanced ion exchange.…”

Section: Outcome Measuresmentioning

confidence: 99%

“…Based on experiment done by Rosenqvist and coworkers [18], it is apparent that there is a strong interaction between BAG and clodronate resulting in an enhanced ion exchange. The interaction seems to be such that an extended ion exchange between the BAG and clodronate results in a layer of calcium clodronate on the surface of the bioactive glass.…”

Section: Outcome Measuresmentioning

confidence: 99%

A Pilot Study - Comparison between a Novel Combination of Bioactive Glass with Clodronate and Bioactive Glass Alone as a Treatment for Chronic Periodontitis

Rosenqvist¹,

Gursöy

Könönen

et al. 2017

J Biotechnol Biomater

Self Cite

View full text Add to dashboard Cite

Citation: Rosenqvist K, Gürsoy M, Könönen E, Gürsoy UK, Juppo AM (2017) AbstractBioactive glass (BAG) and clodronate are both used for bone regeneration. In this pilot clinical study, we compared the effect of BAG and a novel BAG+clodronate combination as a topical maintenance phase treatment for chronic periodontitis.Two dental residual pockets were treated in each subject (n=10): one with BAG alone and the other with combination product, by applying the products subgingivally for 10 min once a week for four weeks. We describe the effects of these investigational products to the clinical parameters of periodontitis and two bone metabolism markers (osteoprotegerin and osteocalcin). Additionally, subjective satisfaction for the treatment was evaluated.The results must be considered as directional, understanding that further investigation is needed to confirm the findings. Based on clinical parameters measured both treatments could benefit as maintenance therapy for chronic periodontitis. The positive effect of the combination product on tooth sensitivity may bring additional benefits in comparison to the use of BAG alone. Both treatments were well tolerated and safe.

show abstract

Interaction of bioactive glass with clodronate

Cited by 10 publications

References 23 publications

Risedronate adsorption on bioactive glass surface for applications as bone biomaterial

Risedronate adsorption on bioactive glass surface for applications as bone biomaterial

Composite Membranes of Poly(ε-caprolactone) with Bisphosphonate-Loaded Bioactive Glasses for Potential Bone Tissue Engineering Applications

A Pilot Study - Comparison between a Novel Combination of Bioactive Glass with Clodronate and Bioactive Glass Alone as a Treatment for Chronic Periodontitis

Contact Info

Product

Resources

About