Interaction of Aqueous Extract of Pleurotus pulmonarius (Fr.) Quel‐Champ. with Glyburide in Alloxan Induced Diabetic Mice

Abstract

Mushrooms are low calorie food with very little fat and are highly suitable for obese persons. With no starch and very low sugars, they are the ‘delight of the diabetics’. Combination of herbal drugs (or isolated phytochemicals) is found to be beneficial in certain diseases when given along with conventional drugs. The aim of the present study was to evaluate the effects of aqueous extract of Pleurotus pulmonarius (Lentinaceae) (called as PP-aqu) and its interaction with glyburide in alloxan induced diabetic mice. The diabetic mice treated were with PP-aqu (500 mg/kg, p.o.) alone or combination with glyburide (10 mg/kg, p.o.) for 28 days. Blood samples were collected by orbital sinus puncture using heparinized capillary glass tubes and were analyzed for serum glucose on 0, 7th, 14th, 21st and 28th days. Body weights and mortality were noted during the study period. In oral glucose tolerance test (OGTT), glucose (2.5 g/kg, p.o.) was administered with either vehicle, PP-aqu alone or in combination with glyburide and serum glucose level analyzed at 0, 30, 60 and 120 min after drug administration. Administration of PP-aqu (500 mg/kg) and its combination with glyburide (10 mg/kg) significantly (P < 0.001) decreased serum glucose level in diabetic mice. In OGTT, glyburide or PP-aqu treatment alone or their combination produced significant (P < 0.001) increase in glucose threshold. Thus we suggest that P. pulmonarius showed potent and synergistic antihyperglycemic effect in combination with glyburide.

Effect of Supplements on Growth and Nutritional Content of Pleurotus pulmonarius Cultivated on Rice Straw

“…An orally administered hot water extract of P. pulmonarius had a significant antihyperglycemic effect, halted the progression of diabetes and reduced the mortality of alloxan induced diabetic mice by approximately 50%. It showed a synergistic effect with the antidiabetic drug glibenclamide, supporting the possibility of effective combination therapy of glibenclamide and P. pulmonarius for diabetes (Badole, 2008). P. pulmonarius have antimicrobial properties and exhibit antioxidant activity also (Ramesh and Pattar, 2010).…”

Nutritional and medicinal potential of Grewia subinaequalis DC. (syn. G. asiatica.) (Phalsa)

“…In this context, other medicinal plants, such as Cassia auriculata (Latha and Pari, 2003). Pleurotus pulmonarius (Badole et al, 2000) have been reported to possess similar effects. Flavonoids, alkaloids, tannins and phenolics are the other bioactive principles reported to possess antihyperglycaemic activity.…”

Oyster Mushroom : Answer to Human Ailments:a Review

“…Feeding of mushroom powder increases the excretion of total lipids and cholesterol through fecal matter. Mevinolin (a statin: Present in fruiting bodies of P. ostreatus and P. citrinopileatus) exhibited antihypocholesterolemic activities [54,55]. P. pulmonarius exhibited potent.…”