Interaction of Antioxidant Trace Minerals Affecting Blood Picture Including Antioxidant Profile of Healthy Buffalo (Bubalus bubalis) Calves

Mudgal, Vishal; Garg, Anil Kumar; Dass, Ram; Rawat, Mayank

doi:10.1007/s12011-022-03122-9

Cited by 1 publication

(2 citation statements)

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“…[30][31][32][33] Similar to iron, Cu is an essential trace element to maintain good health for living organisms. [34,35] In this article, we report that ultra-small Cu 2−x Se nanoparticles (CS NPs) could significantly polarize M0-and M2-like macrophages into M1 phenotype in vitro, and drastically reprogram tumor-supportive M2-like TAMs toward anti-tumor M1 phenotype in vivo (Scheme 1), which increased anti-tumor efficacy by inducing robust T-cell immunity. We reveal that CS NPs can increase intracellular reactive oxygen species (ROS) in macrophages, trigger auto-ubiquitination of tumor necrosis factor receptor-associated factor 6 (TRAF6), and result in enhanced activation of interferon regulatory factor 5 (IRF5), which induced expression of its own downstream gene IL-23, and eventually activated M1 polarization.…”

Section: Introductionmentioning

confidence: 99%

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Reprogramming Tumor‐Associated Macrophages via ROS‐Mediated Novel Mechanism of Ultra‐Small Cu₂₋_xSe Nanoparticles to Enhance Anti‐Tumor Immunity

Zheng

Han

Wang

et al. 2021

Adv Funct Materials

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Reprogramming tumor‐associated macrophages (TAMs) from tumor‐supportive M2 phenotype to anti‐tumor M1 phenotype holds great promise in tumor immunotherapy. However, there are few reports on the remodeling of TAMs by inorganic nanoparticles due to their unclear intrinsic polarization mechanism. In this article, a novel signaling pathway of repolarizing TAMs into M1‐like macrophages is reported to boost anti‐tumor immunity using ultra‐small Cu2−xSe nanoparticles (CS NPs). The mechanism is totally different from the conventional ROS‐mediated polarization mechanism. It is revealed that CS NPs can effectively generate ROS in the macrophages to trigger auto‐ubiquitination of tumor necrosis factor receptor‐associated factor 6 (TRAF6), which activates the interferon regulatory factor 5 (IRF5) to facilitate the expression of its downstream gene interleukin‐23 (IL‐23), and eventually remodels the TAMs into M1‐like macrophages. It is shown that CS NPs can significantly inhibit the growth of melanoma tumor (B16F10) by repolarizing TAMs into M1‐like macrophages, and enhance the adaptive anti‐tumor immunity by inducing the infiltration of CD8+ T cells. Moreover, it is found that CS NPs can also effectively inhibit the recurrence of distal tumor. The study shows the novel macrophage polarization mechanism for TAMs‐targeted cancer immunotherapy, and demonstrates the great potential of ultra‐small Cu2−xSe nanoparticles in cancer immunotherapy.

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Section: Introductionmentioning

confidence: 99%

“…[ 30–33 ] Similar to iron, Cu is an essential trace element to maintain good health for living organisms. [ 34,35 ]…”

Section: Introductionmentioning

confidence: 99%

Reprogramming Tumor‐Associated Macrophages via ROS‐Mediated Novel Mechanism of Ultra‐Small Cu₂₋_xSe Nanoparticles to Enhance Anti‐Tumor Immunity

Zheng

Han

Wang

et al. 2021

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

Interaction of Antioxidant Trace Minerals Affecting Blood Picture Including Antioxidant Profile of Healthy Buffalo (Bubalus bubalis) Calves

Cited by 1 publication

References 77 publications

Reprogramming Tumor‐Associated Macrophages via ROS‐Mediated Novel Mechanism of Ultra‐Small Cu₂₋_xSe Nanoparticles to Enhance Anti‐Tumor Immunity

Reprogramming Tumor‐Associated Macrophages via ROS‐Mediated Novel Mechanism of Ultra‐Small Cu₂₋_xSe Nanoparticles to Enhance Anti‐Tumor Immunity

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Interaction of Antioxidant Trace Minerals Affecting Blood Picture Including Antioxidant Profile of Healthy Buffalo (Bubalus bubalis) Calves

Cited by 1 publication

References 77 publications

Reprogramming Tumor‐Associated Macrophages via ROS‐Mediated Novel Mechanism of Ultra‐Small Cu2−xSe Nanoparticles to Enhance Anti‐Tumor Immunity

Reprogramming Tumor‐Associated Macrophages via ROS‐Mediated Novel Mechanism of Ultra‐Small Cu2−xSe Nanoparticles to Enhance Anti‐Tumor Immunity

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Resources

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Reprogramming Tumor‐Associated Macrophages via ROS‐Mediated Novel Mechanism of Ultra‐Small Cu₂₋_xSe Nanoparticles to Enhance Anti‐Tumor Immunity

Reprogramming Tumor‐Associated Macrophages via ROS‐Mediated Novel Mechanism of Ultra‐Small Cu₂₋_xSe Nanoparticles to Enhance Anti‐Tumor Immunity