Interaction of antiarrhythmic drugs with model membranes

Suwalsky, Mario; Sánchez, Iris; Bagnara, Margarita; Sotomayor, Carlos P.

doi:10.1016/0005-2736(94)90255-0

Cited by 19 publications

(4 citation statements)

References 18 publications

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“…As it has previously been reported, water did not affect very much the structure and, therefore, the X-ray pattern of DMPE. This is because DMPE molecules pack very tightly with a number of hydrophobic and hydrophilic interactions and hydrogen bonds [ 141, being its multibilayer arrangement very compact and difficult to perturbate [7]. However, it was observed that Zn'+ in a concentration as low as M produced a considerable diminishing of DMPE reflection intensities, disappearing many of them.…”

Section: X-ray Studiesmentioning

confidence: 99%

Interaction of Zn²⁺Ions with Phospholipid Multilayers

Suwalsky

Ungerer

Aguilar

et al. 1996

International Journal of Polymeric Materials

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Phospholipids are large natural amphipathic molecules which, in contact with water, assemble into higher molecular aggregates. The most relevant one is the bilayer for its relation to the structure, properties and functions of cell membranes. Given their structural complexity phospholipid bilayers are usually used as models for studying how biologically relevant chemicals affect the structure and functions of biomembranes. Zn is a trace element essential for the functional integrity of cell membranes. It is also a common contaminant of sea waters. Therefore, it was thought of interest to study the interaction of ZnZ+ ions with phospholipid bilayers in order to understand the way they interact with cell membranes. With this aim Zn2+, in a wide range of concentrations, was made to interact with multibilayers of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylethanolamine (DMPE). This study was performed by X-ray diffraction. Besides, the interaction of Znz+ with DMPC liposomes was studied by fluorescence spectroscopy. The results showed that indeed Zn2+ interacted with both phospholipids. As its concentration increased it produced first a disorder effect which was reversed at higher concentrations.

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Section: X-ray Studiesmentioning

confidence: 99%

Interaction of Zn²⁺Ions with Phospholipid Multilayers

Suwalsky

Ungerer

Aguilar

et al. 1996

International Journal of Polymeric Materials

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“…Several mechanisms have been proposed to explain the link between antiarrhythmic drugs and aPL induction. The most plausible among these is a non-specific interaction of antiarrhythmic agents with membrane phospholipids, situated close to the sodium channels, which may trigger an initial event leading to self-reactivity (117).…”

Section: Drugsmentioning

confidence: 99%

Environmental Triggers of Autoreactive Responses: Induction of Antiphospholipid Antibody Formation

2019

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Antiphospholipid antibodies (aPLs) comprise a diverse family of autoantibodies targeted against proteins with the affinity toward negatively charged phospholipids or protein-phospholipid complexes. Their clinical significance, including prothrombotic potential of anti-cardiolipin antibodies (aCLs), anti-β2-glycoprotein I antibodies (aβ2-GPIs), and lupus anti-coagulant (LA), is well-established. However, the ontogeny of these pathogenic aPLs remains less clear. While transient appearance of aPLs could be induced by various environmental factors, in genetically predisposed individuals these factors may eventually lead to the development of the antiphospholipid syndrome (APS). Since the first description of APS, it has been found that a wide variety of microbial and viral agents influence aPLs production and contribute to clinical manifestations of APS. Many theories attempted to explain the pathogenic potential of different environmental factors as well as a phenomenon termed molecular mimicry between β2-GPI molecule and infection-relevant structures. In this review, we summarize and critically assess the pathogenic and non-pathogenic formation of aPLs and its contribution to the development of APS.

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“…This phenomenon allows the incorporation of procaine into DMPC bilayers, its interaction with the lipid polar groups and the ensuing total perturbation of its polar region at a 360 mM concentration. In contrast, DMPE molecules pack tighter than those of DMPC due to their smaller polar group and inter-lipid hydrogen bonds between amino and phosphate groups, resulting in a very stable bilayer system that is not significantly affected by water [24] nor by a number of compounds [25].…”

Section: X-ray Diffraction Studies Of Dmpc and Dmpe Multilayersmentioning

confidence: 99%