Interaction of alcohol and stress at the cardiovascular level

Pohorecky, Larissa A.

doi:10.1016/0741-8329(90)90045-e

Cited by 23 publications

(10 citation statements)

References 109 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This possible added benefit against SCD could be mediated by the beneficial effects on plaque rupture 19 or thrombosis 25 often documented on autopsies of SCD victims 26,27 or through effects on the autonomic nervous system. 28 In contrast to the findings for SCD, the relationship with nonfatal MI and nonsudden CHD death was linear, without an increase in RR at the highest level of intake. In addition, risks are not significantly reduced for nonfatal MI until consumption levels reach 1 drink/d, the same level at which risk for SCD begins to increase.…”

Section: Discussioncontrasting

confidence: 49%

Moderate Alcohol Consumption and the Risk of Sudden Cardiac Death Among US Male Physicians

et al. 1999

View full text Add to dashboard Cite

Background-Individuals who consume high amounts of alcohol (Ͼ5 drinks/d) have increased risks of ventricular arrhythmia and sudden cardiac death (SCD). However, the relationship is less clear for drinkers of light-to-moderate amounts. Methods and Results-We prospectively assessed whether light-to-moderate alcohol drinkers have a decreased risk of SCD among 21 537 male participants in the Physicians Health Study who were free of self-reported cardiovascular disease and provided complete information on alcohol intake at study entry. Over 12 years of follow-up, 141 SCDs were confirmed. After control for multiple confounders, men who consumed 2 to 4 drinks/wk (RRϭ0.40; 95% CI, 0.22 to 0.75; Pϭ0.004) or 5 to 6 drinks/wk (RRϭ0.21; 95% CI, 0.08 to 0.56; Pϭ0.002) at baseline had significantly reduced risks of SCD compared with those who rarely or never consumed alcohol. The relationship for SCD was U-shaped (Pϭ0.002), with the risk approaching unity at Ն2 drinks/d. In contrast, the relationship of alcohol intake and nonsudden CHD death was L-shaped or linear (P for trendϭ0.02). Conclusions-In these prospective data, men who consumed light-to-moderate amounts of alcohol (2 to 6 drinks/wk) had a significantly reduced risk of SCD compared with those who rarely or never consumed alcohol. (Circulation. 1999;100:944-950.)

show abstract

Section: Discussioncontrasting

confidence: 49%

Moderate Alcohol Consumption and the Risk of Sudden Cardiac Death Among US Male Physicians

et al. 1999

View full text Add to dashboard Cite

show abstract

“…Dysregulation of CRF 1 receptors may contribute to several stress-induced psychiatric disorders, such as human alcoholism[53,63], and numerous reports suggest that stressful life events and maladaptive responses elicit alcohol drinking and relapse behavior[64]. However, the molecular and cellular mechanisms underlying stress-induced alcohol drinking are still unknown.…”

Section: Discussionmentioning

confidence: 99%

Presynaptic CRF1 Receptors Mediate the Ethanol Enhancement of GABAergic Transmission in the Mouse Central Amygdala

Nie

Zorrilla

Madamba

et al. 2009

The Scientific World JOURNAL

View full text Add to dashboard Cite

Corticotropin-releasing factor (CRF) is a 41-amino-acid neuropeptide involved in stress responses initiated from several brain areas, including the amygdala formation. Research shows a strong relationship between stress, brain CRF, and excessive alcohol consumption. Behavioral studies suggest that the central amygdala (CeA) is significantly involved in alcohol reward and dependence. We recently reported that the ethanol augmentation of GABAergic synaptic transmission in rat CeA involves CRF1 receptors, because both CRF and ethanol significantly enhanced the amplitude of evoked GABAergic inhibitory postsynaptic currents (IPSCs) in CeA neurons from wild-type (WT) and CRF2 knockout (KO) mice, but not in neurons of CRF1 KO mice. The present study extends these findings using selective CRF receptor ligands, gene KO models, and miniature IPSC (mIPSC) analysis to assess further a presynaptic role for the CRF receptors in mediating ethanol effects in the CeA. In whole-cell patch recordings of pharmacologically isolated GABAAergic IPSCs from slices of mouse CeA, both CRF and ethanol augmented evoked IPSCs in a concentration-dependent manner, with low EC50s. A CRF1 (but not CRF2) KO construct and the CRF1-selective nonpeptide antagonist NIH-3 (LWH-63) blocked the augmenting effect of both CRF and ethanol on evoked IPSCs. Furthermore, the new selective CRF1 agonist stressin1, but not the CRF2 agonist urocortin 3, also increased evoked IPSC amplitudes. Both CRF and ethanol decreased paired-pulse facilitation (PPF) of evoked IPSCs and significantly enhanced the frequency, but not the amplitude, of spontaneous miniature GABAergic mIPSCs in CeA neurons of WT mice, suggesting a presynaptic site of action. The PPF effect of ethanol was abolished in CeA neurons of CRF1 KO mice. The CRF1 antagonist NIH-3 blocked the CRF- and ethanol-induced enhancement of mIPSC frequency in CeA neurons. These data indicate that presynaptic CRF1 receptors play a critical role in permitting or mediating ethanol enhancement of GABAergic synaptic transmission in CeA, via increased vesicular GABA release, and thus may be a rational target for the treatment of alcohol abuse and alcoholism.

show abstract

“…Beer may be particularly valuable as compared to other alcoholic beverages, as the hop-derived bittering agents are said to have sedative and hypnotic impacts. [101] Immune system stimulation (immunomodulation). It was observed that beer stimulated non-specific immunity in rats.…”

Section: Medicinal Valuesmentioning

confidence: 99%

“…[12] The fact that moderate consumption of alcohol leads to stress alleviation may also take part in reducing heart problems. [101] Morrell [102] suggested that beneficial effects of alcohol consumption are consequences of drinking impacts on relaxation. Beer may be particularly valuable as compared to other alcoholic beverages, as the hop-derived bittering agents are said to have sedative and hypnotic impacts.…”

Section: Medicinal Valuesmentioning

confidence: 99%

Health-Related Aspects of Beer: A Review

Sohrabvandi

Mortazavian

Rezaei

2012

International Journal of Food Properties

View full text Add to dashboard Cite

Beer is consumed worldwide and is a universally popular beverage. This is due to its sensory, nutritional, and medicinal properties. Surveys have shown that light to moderate consumption of alcoholic beverages (including beer) with relatively low alcohol contents can provide various favorable impacts on humans' health, including nutritional benefits, anti-mutagenic and anti-carcinogenic effects, reduction of cardiovascular disease (cardioprotective effect), hypolipidemic effect, immune system stimulation, anti-osteoporosis effect, and reducing risk of dementia. On the contrary, consumption of these beverages in excessive amounts results in some heath disorders, such as allergy induction, increase in the plasma concentration of uric acid, mutation and cancer induction, increase in the risk of dementia, obesity, and some social misbehaviors. Health-related aspects of beer (both positive and negative impacts) have been comprehensively reviewed in this article.

show abstract

Interaction of alcohol and stress at the cardiovascular level

Cited by 23 publications

References 109 publications

Moderate Alcohol Consumption and the Risk of Sudden Cardiac Death Among US Male Physicians

Moderate Alcohol Consumption and the Risk of Sudden Cardiac Death Among US Male Physicians

Presynaptic CRF1 Receptors Mediate the Ethanol Enhancement of GABAergic Transmission in the Mouse Central Amygdala

Health-Related Aspects of Beer: A Review

Contact Info

Product

Resources

About