Moderate Alcohol Consumption and the Risk of Sudden Cardiac Death Among US Male Physicians

Chen, Albert; Manson, JoAnn E.; Cook, Nancy R.; Ajani, Umed A.; Gaziano, J. Michael; Hennekens, C. H.

doi:10.1161/01.cir.100.9.944

Cited by 178 publications

(103 citation statements)

References 33 publications

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“…In the same study the evaluation of all-cause mortality found between alcohol consumption and cardiovascular events not a linear but a U-shaped correlation, with the lowest mortality in subjects with moderate alcohol consumption (about one drink per day). Albert et al (1999) observed a reduction in the risk of Effects of moderate sicilian red wine consumption G Avellone et al sudden cardiac death correlated to alcohol consumption, also with a U-shaped relationship. The incidence of sudden cardiac death is, in fact, high in nondrinkers, decreases in drinkers (about one drink per day) and increases in drinkers of two or more drinks per day.…”

Section: Discussionmentioning

confidence: 92%

Effects of moderate Sicilian red wine consumption on inflammatory biomarkers of atherosclerosis

et al. 2005

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Objective: The aim of the study is to evaluate the effect of moderate Sicilian red wine consumption on cardiovascular risk factors and, in particular, on some inflammatory biomarkers. Methods: A total of 48 subjects of both sexes who were nondrinkers or rare drinkers of moderate red wine were selected and randomly subdivided into two groups assigned to receive with a crossover design a Sicilian red wine (Nero d'Avola or Etna Torrepalino) during meals: Group A (n ¼ 24), in whom the diet was supplemented for 4 weeks with 250 ml/day of red wine, followed by 4 weeks when they returned to their usual wine intake; and Group B (n ¼ 24), in whom the usual wine intake was maintained for 4 weeks, followed by 4 weeks when the diet was supplemented with 250 ml/day of red wine. The following were values measured in all tests: blood glucose, total and HDL-cholesterol and triglycerides, LDL-cholesterol, LDL/HDL ratio, apolipoproteins A1 and B, Lp(a), plasma C-reactive protein, TGFb1, D-Dimer, Factor VII , PAI Ag, t-PA Ag, fibrinogen, oxidized LDL Ab, total plasma antioxidant capacity. Results: At the end of the red wine intake period, LDL/HDL, fibrinogen, factor VII, plasma C-reactive protein and oxidized LDL Ab were significantly decreased, while HDL-C, Apo A1,TGFb1, t-PA, PAI and total plasma antioxidant capacity were significantly increased. Conclusions: Our results show a positive effect of two Sicilian red wines on many risk factors and on some inflammatory biomarkers, suggesting that a moderate consumption of red wine in the adult population is a positive component of the Mediterranean diet.

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Section: Discussionmentioning

confidence: 92%

Effects of moderate Sicilian red wine consumption on inflammatory biomarkers of atherosclerosis

et al. 2005

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“…The physical activity and alcohol consumption results of the present study are in conformity with the studies suggesting a possible interaction between hyperlipidemia and periodontal disease. 48,49,65,67 A probable association between hyperlipidemia and periodontitis were investigated by assessing the biochemical parameters together with periodontal parameters in a number of studies. 22,31,36,37,47,62,[67][68][69] Sangwan et al 37 reported significant positive associations between PD and TC, CAL and LDL-C as well as between GI and TG.…”

Section: Discussionmentioning

confidence: 99%

“…Subjects were also asked for alcohol consumption and categorized as regular, rare or never. 48 According to the amount of physical activity, subjects were classified as active, partially active or inactive. 49 …”

Section: Study Populationmentioning

confidence: 99%

Is there a relationship between hyperlipidemia and periodontitis?

Yıldırım¹,

Katı²,

Ağralı³

et al. 2017

Yeditepe J Dent

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“…Contrary, consumption of light-to-moderate amounts of alcohol (2 to 6 drinks/week) correlated with significantly reduced risk of SCD (Albert et al 1999). Cocaine can also contribute to sudden cardiac death due to its pro-arrhythmic effect (Billman 1990).…”

Section: Risk Factors For Sudden Cardiac Deathmentioning

confidence: 99%

Role of risk stratification and genetics in sudden cardiac death

Rai

Agrawal

2017

Can. J. Physiol. Pharmacol.

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Keyword:Sudden cardiac death, coronary artery disease, heart failure, Arrhythmias, Atrial fibrillation https://mc06.manuscriptcentral.com/cjpp-pubs AbstractSudden cardiac death (SCD) is a major public health issue due to its increasing incidence in the general population and the difficulty in identifying high-risk individuals.Nearly 300,000-350,000 patients in the United States and 4-to 5 million patients in the world die from SCD. Coronary artery disease and advanced heart failure are the main etiology for SCD. Ischemia of any cause precipitates lethal arrhythmias, and ventricular tachycardia and ventricular fibrillation are the most common lethal arrhythmias precipitating SCD. Pulse-less electrical activity, brady-arrhythmia and electromechanical dissociation also result in SCD.Most sudden cardiac deaths occur out-of-the-hospital setting, so it is difficult to estimate the public burden, which results in overestimating the incidence of SCD. The insufficiency and limited predictive value of various indicators and criteria for SCD result in the increasing incidences. As a result, there is a need to develop better risk stratification criteria and find modifiable variables to decrease the incidence. Primary and secondary prevention and treatment of SCD need further research. This critical review is focused on the etiology, risk factors, prognostic factors and importance of risk stratification of SCD.Key words: Sudden cardiac death, Coronary artery disease, Heart failure, Arrhythmias, Atrial fibrillation, Ventricular fibrillation, Channelopathies, Risk stratification, Prevention

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Moderate Alcohol Consumption and the Risk of Sudden Cardiac Death Among US Male Physicians

Cited by 178 publications

References 33 publications

Effects of moderate Sicilian red wine consumption on inflammatory biomarkers of atherosclerosis

Effects of moderate Sicilian red wine consumption on inflammatory biomarkers of atherosclerosis

Is there a relationship between hyperlipidemia and periodontitis?

Role of risk stratification and genetics in sudden cardiac death

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