Interaction of a dengue virus NS1-derived peptide with the inhibitory receptor KIR3DL1 on natural killer cells

Townsley, Elizabeth; O’Connor, Geraldine M.; Cosgrove, Cormac; Woda, Marcia; Thomas, Stephen J.; Kalayanarooj, Siripen; Yoon, Inhyun; Nisalak, Ananda; Srikiatkhachorn, Anon; Green, Sharone; Stephens, Henry A.F.; Gostick, Emma; Price, David A.; Carrington, Mary; Alter, Galit; McVicar, Daniel W.; Rothman, Alan L.; Mathew, Anuja

doi:10.1111/cei.12722

Cited by 32 publications

(26 citation statements)

References 48 publications

(139 reference statements)

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“…Influenza is another key candidate, with highly virulent epidemics linked to the combination of dense population, agriculture and industrialization (Cao et al 2009;Chen et al 2006). Human specific viral hepatitis infections and arboviruses are also endemic to China and South East Asia, including Japanese encephalitis, Dengue and chikungunya (Bashirova et al 2006;Khakoo et al 2004;Naiyer et al 2017;Petitdemange et al 2011;Thons et al 2017;Townsley et al 2016).…”

Section: Discussionmentioning

confidence: 99%

Genetically Determined Strength of Natural Killer Cells is Enhanced by Adaptive HLA class I Admixture in East Asians

Deng

Zhen

Harrison

et al. 2020

Preprint

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Human natural killer (NK) cells are essential for controlling infection, cancer and fetal development. NK cell functions are modulated by interactions between polymorphic inhibitory killer cell immunoglobulin-like receptors (KIR) and polymorphic HLA-A, -B and -C ligands expressed on tissue cells. All HLA-C alleles encode a KIR ligand and contribute to reproduction and immunity. In contrast, only some HLA-A and -B alleles encode KIR ligands and they focus on immunity. By high-resolution analysis of KIR and HLA-A, -B and -C genes, we show that the Chinese Southern Han are significantly enriched for interactions between inhibitory KIR and HLA-A and -B. This enrichment has had substantial input through population admixture with neighboring populations, who contributed HLA class I haplotypes expressing the KIR ligands B*46:01 and B*58:01, which subsequently rose to high frequency by natural selection. Consequently, over 80% of Southern Han HLA haplotypes encode more than one KIR ligand. Complementing the high number of KIR ligands, the Chinese Southern Han KIR locus combines a high frequency of genes expressing potent inhibitory KIR, with a low frequency of those expressing activating KIR. The Southern Han centromeric KIR region encodes strong, conserved, inhibitory HLA-C specific receptors, and the telomeric region provides a high number and diversity of inhibitory HLA-A and -B specific receptors. In all these characteristics, the Southern Han represent other East Asians, whose NK cell repertoires are thus enhanced in quantity, diversity and effector strength, likely through natural selection for resistance to endemic viral infections.

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Section: Discussionmentioning

confidence: 99%

Genetically Determined Strength of Natural Killer Cells is Enhanced by Adaptive HLA class I Admixture in East Asians

Deng

Zhen

Harrison

et al. 2020

Preprint

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“…For this reason, the difference in KIR2DL3 expression should also be interpreted with caution. Although KIRs have been implicated in dengue disease severity (47)(48)(49), whether the expression of KIRs on CD8 + T cells has any functional role in anti-DENV immunity warrants further investigation.…”

Section: Discussionmentioning

confidence: 99%

Dengue-specific CD8+ T cell subsets display specialized transcriptomic and TCR profiles

Tian¹,

Babor²,

Lane³

et al. 2019

Journal of Clinical Investigation

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“…The interaction of NKB1 with specific HLA-B antigens on a target cell inhibits cell-mediated cytotoxicity, possibly by delivering a negative signal that prevents NK cell activation. Therefore, the interactions between MHC I and KIRs may regulate NK responses to antigenic challenge ( 30 ).…”

Section: Discussionmentioning

confidence: 99%

Natural killer cells inhibit pulmonary metastasis of hepatocellular carcinoma in nude mice

Hong¹,

Zhao

Yin

et al. 2016

Oncology Letters

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Natural killer (NK) cells have been demonstrated to inhibit tumor growth. However, the role of NK cells in the inhibition of hepatocellular carcinoma metastasis is not well understood. The present study aimed to investigate the roles that NK cells may serve in inhibiting hepatocellular carcinoma metastasis. The role of isolated NK cells in the inhibition, proliferation, migration and invasion of the hepatoma cell line, MHCC97-H, was examined in vitro. Additionally, the survival rate of NK cells labeled with carboxyfluorescein diacetate-succinimidyl ester was assessed in vivo. An orthotopic implantation model was used to evaluate the role of NK cells in suppressing MHCC97-H cells in vivo. The effect of interleukin (IL)-2 stimulation on the tumor-inhibitory role of the NK cells was measured indirectly by analyzing the expression of various NK cell receptors and activated NK cell markers. It was observed that the NK cells inhibited the proliferation, migration and invasion of the MHCC97-H cells in vitro. Furthermore, the NK cells demonstrated long-term survival in the livers of the nude mice, and inhibited lung metastasis of hepatocellular carcinoma in vivo. However, liver tumor growth was not inhibited by the NK cells. IL-2 was identified to enhance the tumor-inhibitory effect of NK cells. The present study concludes that IL-2 may enhance the antitumor activity of the NK cells, and thereby inhibit the metastases of hepatocellular carcinoma in mice.

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Interaction of a dengue virus NS1-derived peptide with the inhibitory receptor KIR3DL1 on natural killer cells

Cited by 32 publications

References 48 publications

Genetically Determined Strength of Natural Killer Cells is Enhanced by Adaptive HLA class I Admixture in East Asians

Genetically Determined Strength of Natural Killer Cells is Enhanced by Adaptive HLA class I Admixture in East Asians

Dengue-specific CD8+ T cell subsets display specialized transcriptomic and TCR profiles

Natural killer cells inhibit pulmonary metastasis of hepatocellular carcinoma in nude mice

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