Interaction between the polymorphisms of the renin–angiotensin system in preeclampsia

Abstract

Preeclampsia is considered to be a multifactorial and multisystemic disorder with a genetic predisposition. Alterations in the reninangiotensin system are considered to play a significant role in the pathogenesis of the disease. In order to investigate the possible association of the three most common polymorphisms of the renin-angiotensin system genes with preeclampsia we have examined 41 women with preeclampsia and 102 normotensive pregnant women. DNA samples were genotyped for the M235T polymorphism of the angiotensinogen gene (AGT), the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme gene (ACE) and the A1166C polymorphism of the angiotensin II type 1 receptor gene (AT1R) by PCR. Allele and genotype frequencies of the AGT gene polymorphism differed between the two study groups. The TT genotype of the M235T polymorphism was significantly increased in women who developed preeclampsia (P < 0:02). In addition, women with preeclampsia and TT genotype had more frequently the DD genotype or the 1166C allele than the control group showing a significant interaction between the genes. In conclusion, we found an association between the angiotensinogen variant 235T and preeclampsia as well as an interaction between the variant 235T and the two other genes studied. #

Meta analysis of angiotensin-converting enzyme I/D polymorphism as a risk factor for preeclampsia in Chinese women

“…A common 287-bp Alu repeat sequence insertion or deletion (I/D) within intron 16 in the ACE gene has been reliably associated with substantial differences in the plasma ACE concentration, whereas the mean plasma ACE level of DD subjects was about twice that of II individuals (Tiret et al, 1992). Thus, the polymorphism has been considered a strong candidate for PE risk; however, a number of contradictory findings have been reported (Rohacs et al, 1997;Bouba et al, 2003;Galao et al, 2004;Kaur et al, 2005). The inconsistency of results has been attributed to insufficient statistical power caused by small sample size.…”

AGT M235T polymorphism contributes to risk of preeclampsia: evidence from a meta-analysis

“…8,[11][12][13][14][15][16] The results, however, were controversial in different studies. Some investigators reported that the AGT M235T polymorphism was associated with the risk of PE in Caucasian 5,17,18 and Japanese patients. 19 In contrast, other investigators have reported that the AGT M235T polymorphism was not a risk factor for the development of PE in Africans, 20 Asians, [21][22][23][24] and Caucasians.…”

Polymorphisms in renin-angiotensin-aldosterone system and vascular endothelial growth factor may cross talk in preeclampsia: a pilot study of maternal and fetal dyads in Indian population

“…Zhou et al found that cyototrophoblastic differentiation and invasion during pregnancy is regulated through VEGF receptor-2 and its expression is deregulated in severe preeclampsia. 2 The VEGF gene is highly polymorphic. Banyasz et al found carriers of allele VEGF G405C occurred less frequently in pre-eclampsia than in controls and that the progression of preeclampsia may be modified by the presence of VEGF 2578A allele.…”