Interaction between stress, cytokines, and salivary cortisol in pregnant and non-pregnant women with gingivitis

Yarkaç, Fatma Uçan; Göktürk, Özge; Demir, Osman

doi:10.1007/s00784-018-2569-9

Cited by 9 publications

(7 citation statements)

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“…Fiorini et al have reported that the levels of IL‐1β, IL‐6, and IL‐8 in GCF are associated with periodontal PD and bleeding on probing in pregnant women (Fiorini et al., 2012). Yarkac et al have shown that the GCF level of IL‐6 is significantly higher in pregnant women compared with non‐pregnant women (Yarkac et al., 2021). In this study, IL‐6 and TNF‐α, two typical pro‐inflammatory cytokines were measured in the GCF of women underwent progesterone intervention.…”

Section: Discussionmentioning

confidence: 99%

Exogenous progesterone short‐termly affects the periodontal environment in perimenopausal women

et al. 2022

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Objective This study aimed to evaluate the effects of exogenous progesterone in the periodontal environment of perimenopausal women. Methods Either with or without periodontitis, 100 perimenopausal women received 3 months of progesterone treatment, as well as age‐matched 100 perimenopausal and 100 postmenopausal women without treatments were enrolled (N = 50). The gingival index (GI), probing depth (PD), clinical attachment level (CAL), and tooth mobility (TM), as well the gingival crevicular fluid (GCF) levels of IL‐6 and TNF‐α were analyzed. Results Periodontitis showed higher GI, PD, and CAL than non‐periodontitis at perimenopausal and postmenopausal periods. In women without periodontitis, the GI and PD, and the GCF levels of IL‐6 and TNF‐α were increased by 3 months of progesterone treatment, but recovered from the 6th month in the absence of progesterone. In women with periodontitis, only the PD was short‐termly increased by progesterone treatment. For those without progesterone treatment, the GI, PD, and TM were not significantly different between perimenopausal and postmenopausal women either with periodontitis or not. Conclusions Exogenous progesterone short‐termly exacerbated the inflammation and PD in perimenopausal women without periodontitis, and the PD in those with periodontitis.

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Section: Discussionmentioning

confidence: 99%

Exogenous progesterone short‐termly affects the periodontal environment in perimenopausal women

et al. 2022

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“…O estresse é um mecanismo biológico caracterizado pela ativação imediata do sistema nervoso simpático e aumento da secreção de adrenalina, seguido da ativação do eixo hipotálamo-hipófise-adrenal e consequente elevação dos níveis de cortisol. (26) A medição dos níveis de cortisol na saliva está ganhando cada vez mais ampla aceitação como método diagnóstico porque eles correspondem apenas a fração bioativa do hormônio, podendo serem avaliados sob várias condições cognitivas e na presença de estresse e ansiedade. (27) Assim, a Terapia Floral, enquanto processo facilitador do autodesenvolvimento do ser humano, gera frequentemente a sensação de relaxamento ou de liberação do excesso de energia disfuncional com consequente redução do estresse.…”

Section: Discussionunclassified

Terapia floral na evolução do parto e na tríade dor-ansiedade-estresse: estudo quase-experimental

Pitilin¹,

Sbardelotto²,

Soares³

et al. 2022

Acta Paulista De Enfermagem

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Conflitos de interesse: nada a declarar.Resumo Objetivo: Avaliar o efeito da Terapia floral na evolução do trabalho de parto e na tríade dor-ansiedade-estresse das mulheres durante o nascimento.Métodos: Estudo quase-experimental realizado no período de maio a julho de 2018 no centro-obstétrico de um hospital referência para a assistência ao nascimento de baixo risco na Região Sul do Brasil, com 60 participantes (30 no Grupo Controle e 30 no Grupo Floral). A intervenção consistiu na administração dos Florais de Bach durante o trabalho de parto combinados por compostos capazes de regatar o equilíbrio emocional em situações de dor, ansiedade e estresse com a adição de 99,75% de conhaque orgânico Francês à 30% para 0,25% da tintura mãe. O grupo placebo recebeu uma mistura combinada de água com adição de 99,75% de conhaque orgânico Francês à 30% para 0,25% da tintura mãe. Ambos foram acondicionados em frascos conta gotas de 30 ml de igual tamanho, formato e característica. Para análise foi utilizado o teste t a fim de comparar as variáveis estudadas antes e após a intervenção e entre os grupos.Resultados: As variáveis analisadas como dilatação cervical, contrações uterinas, ocitocina, cortisol e tempo do trabalho de parto apresentaram diferenças significativas para o Grupo Floral quando comparado com o placebo.Conclusão: A Terapia floral pode ser uma alternativa para a mulher durante o trabalho de parto por auxiliar na progressão do parto sem trazer prejuízos ao recém-nascido.

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“…To estimate the sample size for the current study, a statistical power analysis which was calculated using cortisol levels based on a study conducted by Yarkac et al (27) was performed by using a software (G * Power version 3.1.7, Franz Faul, Kiel, Germany). A total of 60 individuals was estimated to be enough to find a significant difference in cortisol levels (0.50 effect size at an α = 0.05 significance level, actual power = 0.9677, non-centrality parameter = 15.00, critical F = 4.01, numerator df = 1, dominator df = 58).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of psychological stress and cortisol levels in males with and without gingivitis

Aral¹,

Milward²,

Cooper³

et al. 2020

Ann Med Res

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Gingivitis is a prevalent health problem seen most commonly in males. Psychological stress is also associated with periodontal disease. Thus, to evaluate the possible role of stress in gingivitis, this study investigated the psychological stress and cortisol levels in males with and without gingivitis. Material and Methods: Sixty systemically healthy males between 18 and 28 years were divided into two groups, including those with generalized gingivitis (G) (n=30) and periodontally healthy controls (H) (n=30). Gingival crevicular fluid (GCF) and saliva samples were obtained for determination of cortisol levels using enzyme-linked immunosorbent assay. Plaque (PI) and gingival index (GI), bleeding on probing (BOP), probing depth (PD) and clinical attachment level (CAL) were noted. In addition, BECK depression inventory (BDI), Perceived Stress Scale (PSS), and Oral Health Impact Profile-14 (OHIP-14) were recorded from all participants. Results: PI, GI, BOP (p<0.01), and PD (p<0.05) were significantly higher in group G. BDI, PSS, and OHIP-14 scores were not significantly different between groups (p>0.05). Cortisol levels in saliva and GCF were similar between groups (p>0.05). Conclusion:Psychological stress and cortisol levels in GCF and saliva were found to be similar in males with and without gingivitis.

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Interaction between stress, cytokines, and salivary cortisol in pregnant and non-pregnant women with gingivitis

Abstract: Psychosocial stress may increase the risk of periodontal disease by altering the behavioral and immune responses of the individual. Therefore, the levels of stress should be taken into consideration in order to increase the efficacy of periodontal therapy in pregnant patients.

Cited by 9 publications

References 50 publications

Exogenous progesterone short‐termly affects the periodontal environment in perimenopausal women

Exogenous progesterone short‐termly affects the periodontal environment in perimenopausal women

Terapia floral na evolução do parto e na tríade dor-ansiedade-estresse: estudo quase-experimental

Evaluation of psychological stress and cortisol levels in males with and without gingivitis

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