Interaction between poly(ethylene glycol) and water as studied by differential scanning calorimetry

Huang, Long; Nishinari, Katsuyoshi

doi:10.1002/1099-0488(20010301)39:5<496::aid-polb1023>3.0.co;2-h

Cited by 112 publications

(139 citation statements)

References 29 publications

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“…8 While the phase transitions during freeze-thawing of PEGwater systems have also been documented, the phase behavior in frozen PEG-sugar-water systems has not been adequately addressed. 7,[17][18][19][20][21][22][23][24][25] A detailed characterization of the PEG-sugar-water systems is the first step towards understanding the phase behavior of the more complex PEGylated protein-sugar-water systems.…”

Section: Introductionsupporting

confidence: 83%

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Investigation of PEG Crystallization in Frozen PEG–Sucrose–Water Solutions: II. Characterization of the Equilibrium Behavior During Freeze-Thawing

Bhatnagar

Martin

Teagarden

et al. 2010

Journal of Pharmaceutical Sciences

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Section: Introductionsupporting

confidence: 83%

“…2). 19,25 By using multiple heating rates, the PEG-water binary phase diagram could be reliably constructed. At some PEG concentrations (25%, 30%, and 50% w/w), an exotherm at approximately À508C, attributable to solute (and the associated unfrozen water) crystallization was observed (Fig.…”

Section: Eutectic Compositionmentioning

confidence: 99%

Investigation of PEG Crystallization in Frozen PEG–Sucrose–Water Solutions: II. Characterization of the Equilibrium Behavior During Freeze-Thawing

Bhatnagar

Martin

Teagarden

et al. 2010

Journal of Pharmaceutical Sciences

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“…But the molecular weight of these PEGs is usually larger than 1000 Da. 41,42 In this study, the molar mass of PEG units was low (M = 281) and the interactions between water and PEG chains were weak, so the stability of Au@PEG-F NPs was sensitive to solution pH. The sensitivity of the assay to PFCs at different solution pHs was studied with the concentrations of PFOS ranging in 1−1000 μg L −1 .…”

Section: ■ Results and Discussionmentioning

confidence: 96%

Sensitive Colorimetric Visualization of Perfluorinated Compounds Using Poly(ethylene glycol) and Perfluorinated Thiols Modified Gold Nanoparticles

et al. 2014

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In this work, we have developed a novel sensing strategy employing mixed poly(ethylene glycol)-terminated (PEG-thiols) and perfluoroalkyl-terminated (F-thiols) alkanethiols modified gold nanoparticles (Au@PEG-F NPs) as a probe to detect perfluorinated compounds (PFCs) from water samples. PEG-thiols with high density and long carbon chains make the Au NPs probe well-dispersed in solution and stable even in high concentration of salt solution; F-thiols provide specific fluorous−fluorous interactions to PFCs, which results in adsorption of PFCs on Au@PEG-F NPs. The adsorbed PFCs cause the aggregation of Au@PEG-F NPs probes and thus induce the insolubility of probes and precipitation directly from reaction solution due to the superhydrophobicity of perfluorocarbon monolayers, leading to color and absorbance response of the assay to PFCs. The preparation of the Au@PEG-F NPs probe is very simple, and the colorimetric assay based on this mechanism for the detection of PFCs is selective and convenient. Combined with UV−vis spectrophotometry, the assay demonstrates good sensitivities to PFCs with wide linear range. In the designed concentration range, the response of the colorimetric assay to longchain PFCs (perfluoroalkyl chain ≥7) is discerned even as the concentration of these PFCs is as low as 10 μg L −1 . This low-cost and sensitive assay shows great potential to measure total PFCs in water samples. To the best of our knowledge, this is the first application of the specific fluorous−fluorous interactions and Au NPs based probes for colorimetric recognition for PFCs.

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“…7 It thus seems that type A HB interactions between hydroxyl hydrogens of water and oxyethylene oxygens of PEG molecule do not appreciably affect the HB basicity of water. Hydrogen bond acidity.…”

Section: Dipolarity/polarizability Hydrogen Bond Basicity and Hydrogmentioning

confidence: 99%

“…potentiometric, 5 spectroscopic 6 measurements and thermal methods, 7 indicated that the physicochemical properties of water in polymer solutions are significantly changed, compared to those of pure water.…”

mentioning

confidence: 99%

Dipolarity, Hydrogen-Bond Basicity and Hydrogen-Bond Acidity of Aqueous Poly(ethylene glycol) Solutions

et al. 2002

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The interaction of polymers with water has been extensively studied because of its scientific interest and importance in industrial applications.Poly(ethylene glycol) (PEG) has received a great deal of attention due to its unique properties pertinent to biomedical and biotechnical applications such as complete miscibility in water over a wide range of temperatures and molecular weights, very low toxicity, ability to precipitate proteins and nucleic acids and to form two-phase systems with aqueous solutions of other polymers. 1 Previous results by various techniques, such as complex permittivity, 2 partition, 3,4 potentiometric, 5 spectroscopic 6 measurements and thermal methods, 7 indicated that the physicochemical properties of water in polymer solutions are significantly changed, compared to those of pure water. Recently, Zaslavsky et al. 8 reported "polarity" of aqueous PEG solutions measured by a solvatochromic technique. 9 They measured the molar transition energy (ET) for the UV-VIS absorption band of Reichardt's betaine dye 9 in aqueous solutions of PEGs of various molecular weight (MW) at different concentrations, and observed that the polarity of aqueous PEG solutions, represented by ET, decreased with increasing the MW and concentration of PEGs. It has been suggested that the polarity decrease is due to the structuring action of PEG on water and that the observed solvatochromic effects are due to a change of solvent properties produced by the presence of polymer molecules, not due to a direct interaction of the dye with the polymer. 5,8 It is well known that ET is a composite characteristic that actually responds to changes in both a solvent's dipolarity/polarizability and a solvent's hydrogen bond (HB) donor acidity strength. 10,11 This suggests that the ET values alone can not clearly explain whether the presence of PEG molecules in water cause both of the dipolarity/polarizability and HB donor acidity of water or only one of these two properties to be altered. Water is HB basic as well as dipolar and HB acidic.11 In order to fully understand the effect of PEG on water we thought it is important to measure the HB acceptor basicity as well as the dipolarity/polarizability and HB donor acidity of the water in the presence of varying concentration of PEG.In the present work, we used the Kamlet-Taft solvatochromic comparison approach 10 to study dipolarity/polarizability (π*), HB acceptor basicity (β) and HB donor acidity (α) of aqueous PEG solutions. This method has been widely used to measure these properties of many types of solvents and solvent mixtures. [10][11][12][13][14][15][16] The π*, β and α values for neat liquid PEGs at room temperature have also been measured. Terminal hydroxyl groups of a PEG molecule can act as both an HB donor acid and an acceptor base, and oxyethylene repeating units can act as HB acceptor base. PEG molecules with these moieties are certainly dipolar. These properties of neat liquid PEG might be useful in understanding how PEG molecules affect the properties of water in...

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Interaction between poly(ethylene glycol) and water as studied by differential scanning calorimetry

Cited by 112 publications

References 29 publications

Investigation of PEG Crystallization in Frozen PEG–Sucrose–Water Solutions: II. Characterization of the Equilibrium Behavior During Freeze-Thawing

Investigation of PEG Crystallization in Frozen PEG–Sucrose–Water Solutions: II. Characterization of the Equilibrium Behavior During Freeze-Thawing

Sensitive Colorimetric Visualization of Perfluorinated Compounds Using Poly(ethylene glycol) and Perfluorinated Thiols Modified Gold Nanoparticles

Dipolarity, Hydrogen-Bond Basicity and Hydrogen-Bond Acidity of Aqueous Poly(ethylene glycol) Solutions

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