1990
DOI: 10.1016/0014-2999(90)93765-i
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Interaction between methylxanthine and cardioactive drugs

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“…The infusion time was measured in seconds to the moment of the appearance of the first heart reaction to the infusion of the cardioactive drug, then to the appearance of more frequent changes in the ECG record, and finally, to the occurrence of the toxic effect. For adrenaline, only the first reaction was determined, as our experience showed that this parameter appeared to be most reliable (9)(10)(11), which is in concordance with the findings of Turner (12) that rats are the species with highest threat sensitivity to the action of adrenaline. The other two parameters (frequent reactions and toxic effect) showed great interinividual differences because of the fast and non-uniform degradation of adrenaline during its infusion.…”
Section: Preparation Of Rats For the Experimentssupporting
confidence: 84%
“…The infusion time was measured in seconds to the moment of the appearance of the first heart reaction to the infusion of the cardioactive drug, then to the appearance of more frequent changes in the ECG record, and finally, to the occurrence of the toxic effect. For adrenaline, only the first reaction was determined, as our experience showed that this parameter appeared to be most reliable (9)(10)(11), which is in concordance with the findings of Turner (12) that rats are the species with highest threat sensitivity to the action of adrenaline. The other two parameters (frequent reactions and toxic effect) showed great interinividual differences because of the fast and non-uniform degradation of adrenaline during its infusion.…”
Section: Preparation Of Rats For the Experimentssupporting
confidence: 84%