Interaction between methylxanthine and cardioactive drugs

Jakovljevic, Vladimir; Sabo, A.; Popović, M.; Stanulović, M

doi:10.1016/0014-2999(90)93765-i

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“…The infusion time was measured in seconds to the moment of the appearance of the first heart reaction to the infusion of the cardioactive drug, then to the appearance of more frequent changes in the ECG record, and finally, to the occurrence of the toxic effect. For adrenaline, only the first reaction was determined, as our experience showed that this parameter appeared to be most reliable (9)(10)(11), which is in concordance with the findings of Turner (12) that rats are the species with highest threat sensitivity to the action of adrenaline. The other two parameters (frequent reactions and toxic effect) showed great interinividual differences because of the fast and non-uniform degradation of adrenaline during its infusion.…”

Section: Preparation Of Rats For the Experimentssupporting

confidence: 84%

Interaction of diclofenac and ketoprofen with cardioactive drugs in rats

Jakovljević

Sabo

Tomić

et al. 2009

Eur. J. Drug Metabol. Pharmacokinet.

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The interaction of diclofenac and ketoprofen, both applied intraperitoneally in a dose of 8 mg/kg for twenty-eight days, was assessed with cardioactive drugs in rats. Interaction was assessed on the basis of ECG records after the infusion of adrenaline, verapamil or lidocaine to the rats treated with diclofenac or ketoprofen vs control. The infusion time was measured in seconds to the moment of the appearance of the first heart reaction to the infusion of the cardioactive drug, then to the appearance of more frequent changes in the ECG record, and finally, to the occurrence of the toxic effect. It was also measured the plasma concentrations of sodium and potassium ions. As well as diclofenac and ketoprofen concentration, 2 hours after single and 28th dose. ECG patterns revealed no occurrence of cardiotoxic action of diclofenac and ketoprofen. The treatment with diclofenac caused significantly lower sodium plasma concentrations whereas the concentration of potassium was increased. Diclofenac concentrations were the same after a single and multiple doses, whereas concentrations of ketoprofen were significantly higher after a single dose than after its multiple applications.

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Section: Preparation Of Rats For the Experimentssupporting

confidence: 84%